{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:36:20Z","timestamp":1763746580146,"version":"3.38.0"},"reference-count":15,"publisher":"American Veterinary Medical Association (AVMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2007,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Case Description<\/jats:bold>\u2014A 5-year-old neutered male mixed-breed dog was evaluated by a veterinarian because of a 4-week history of progressive lethargy and poor appetite; the dog was then examined at a referral hospital.<\/jats:p>\n<jats:p><jats:bold>Clinical Findings<\/jats:bold>\u2014Hyperglobulinemia was identified via serum biochemical analyses performed before and after arrival at the hospital. Lysis of sternebrae 1 and 2 and sternal lymphadenopathy were detected radiographically. Fine-needle aspirates were collected from the affected sternebrae and lymph node for cytologic examination; findings were consistent with pyogranulomatous inflammation associated with fungal infiltrates. <jats:italic>Geomyces<\/jats:italic> organisms were identified via microbial culture of sternebral aspirates.<\/jats:p>\n<jats:p><jats:bold>Treatment and Outcome<\/jats:bold>\u2014Treatment consisted of oral administration of itraconazole. After 6 months, remodeling of the affected sternebrae and resolution of sternebral lysis were evident radiographically. <jats:italic>Geomyces<\/jats:italic> organisms and pyogranulomatous infiltrates persisted despite clinical improvement. Treatment with itraconazole was continued for an additional 3 months.<\/jats:p>\n<jats:p><jats:bold>Clinical Relevance<\/jats:bold>\u2014Infection with <jats:italic>Geomyces<\/jats:italic> organisms is typically localized to the skin and nail beds. In the dog of this report, systemic dissemination of <jats:italic>Geomyces<\/jats:italic> organisms resulted in lysis of the first 2 sternebrae. Cytologic examination of fine-needle aspirates and microbial culture of samples of the affected sternebrae were important diagnostic tests for successful identification of the organism. Despite 6 months of itraconazole administration and evidence of clinical improvement, fungal organisms persisted in the dog's affected sternebrae. Practitioners should include <jats:italic>Geomyces<\/jats:italic> infection among the differential diagnoses for suspected systemic mycosis and should perform cytologic examination and microbial culture of affected tissue throughout treatment of affected dogs.<\/jats:p>","DOI":"10.2460\/javma.230.4.537","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T12:57:48Z","timestamp":1171544268000},"page":"537-540","source":"Crossref","is-referenced-by-count":24,"title":["Systemic infection with Geomyces organisms in a dog with lytic bone lesions"],"prefix":"10.2460","volume":"230","author":[{"given":"Jay B.","family":"Erne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark C.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Strik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Rick","family":"Alleman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Mycoses","first-page":"430","article-title":"Skin infection due to Geomyces pannorum var. pannorum","volume":"46","author":"Gianni","year":"2003"},{"key":"ref2","series-title":"Acta Dermatovenerol Croat","first-page":"21","article-title":"Geomyces pannorum as a possible causative agent of dermatomycosis and onychomycosis in two patients","volume":"14","author":"Zelenkova","year":"2006"},{"key":"ref3","series-title":"Rev Iberoam Micol","first-page":"128","article-title":"Some micromycetes isolated from spoiled food and soil in Antarctica","volume":"21","author":"Comerio","year":"2004"},{"key":"ref4","series-title":"Mycopathologia","first-page":"303","article-title":"Keratinophilic fungi of poultry farm and feather dumping soil in Tamil Nadu, India","volume":"158","author":"Anbu","year":"2004"},{"key":"ref5","series-title":"Mycopathologia","first-page":"169","article-title":"Keratinophilic fungi in the Antarctic environment","volume":"122","author":"Mercantini","year":"1993"},{"key":"ref6","series-title":"Mycopathologia","first-page":"65","article-title":"Keratinophilic fungi isolated from the air at Pavia","volume":"85","author":"Della Franca","year":"1984"},{"key":"ref7","series-title":"Mycoses","first-page":"590","article-title":"Isolation of keratinophilic fungi from the dust of ferry boats and trains in Italy","volume":"32","author":"Mercantini","year":"1989"},{"key":"ref8","series-title":"Vet Res Commun","first-page":"161","article-title":"Isolation of keratinophilic fungi from the floors of private veterinary clinics in Italy","volume":"20","author":"Mancianti","year":"1996"},{"key":"ref9","series-title":"J Appl Microbiol","first-page":"78","article-title":"Fungi are the predominant micro-organisms responsible for degradation of soil-buried polyester polyurethane over a range of soil water holding capacities","volume":"95","author":"Barratt","year":"2003"},{"key":"ref10","series-title":"Microb Ecol","first-page":"212","article-title":"Aerial transport of keratinaceous substrate and distribution of the fungus Geomyces pannorum in Antarctic soils","volume":"36","author":"Marshall","year":"1998"},{"key":"ref11","series-title":"J Am Vet Med Assoc","first-page":"67","article-title":"Disseminated opportunistic fungal disease in dogs: 10 cases (1982\u20131990)","volume":"207","author":"Watt","year":"1995"},{"key":"ref12","series-title":"J S Afr Vet Assoc","first-page":"222","article-title":"Multifocal Aspergillus terreus discospondylitis in two German Shepherd Dogs","volume":"67","author":"Berry","year":"1996"},{"key":"ref13","series-title":"J Am Vet Med Assoc","first-page":"1877","article-title":"Chronic localized osteomyelitis caused by atypical infection with Blastomyces dermatitidis in a dog","volume":"209","author":"Marcellin-Little","year":"1996"},{"key":"ref14","series-title":"Vet Clin North Am Small Anim Pract","first-page":"721","article-title":"Update on canine and feline fungal diseases","volume":"33","author":"Kerl","year":"2003"},{"key":"ref15","series-title":"Vet Clin North Am Small Anim Pract","first-page":"749","article-title":"Update on antifungal therapy","volume":"33","author":"Grooters","year":"2003"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/230\/4\/javma.230.4.537.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/230\/4\/javma.230.4.537.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/230\/4\/javma.230.4.537.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T13:34:02Z","timestamp":1741354442000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/230\/4\/javma.230.4.537.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2,15]]},"references-count":15,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.2460\/javma.230.4.537","relation":{},"ISSN":["0003-1488"],"issn-type":[{"type":"print","value":"0003-1488"}],"subject":[],"published":{"date-parts":[[2007,2,15]]}}}