{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T15:26:54Z","timestamp":1784820414116,"version":"3.55.0"},"reference-count":50,"publisher":"American Veterinary Medical Association (AVMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2007,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To characterize features and response to treatment of keratoconjunctivitis sicca (KCS) associated with oral administration of etodolac in dogs.<\/jats:p>\n<jats:p><jats:bold>Design<\/jats:bold>\u2014Retrospective case series.<\/jats:p>\n<jats:p><jats:bold>Sample Population<\/jats:bold>\u201465 cases obtained from a survey of veterinary ophthalmologists (group A) and 146 cases reported to Fort Dodge Animal Health (group B).<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Data analyzed included breed, sex, age, weight, dose and duration of etodolac administration, results of Schirmer tear test at the time of diagnosis and last follow-up, treatments, and response to treatments. Groups A and B were analyzed separately by use of forward stepwise logistic regression models developed to predict probability of complete remission or clinical improvement as a function of several variables.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014Most dogs developed severe KCS (84 eyes of 50 dogs [group A]; 111 eyes of 62 dogs [group B]). Resolution of KCS occurred in 7 of 65 (A) and 23 of 146 (B) dogs. No response to treatment was observed in 26 of 65 (A) and 27 of 146 (B) dogs. Fifty-one (A) and 52 (B) dogs had records that were sufficiently complete to use in models. In group B, dogs with etodolac treatment intervals &lt; 6 months prior to the onset of KCS were 4.2 times as likely to have remission as were dogs with treatment intervals \u2265 6 months.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Shorter duration of etodolac administration (&lt; 6 months) was associated with improved outcome in 1 population of dogs. Monitoring of tear production should be considered prior to and during administration of etodolac in dogs.<\/jats:p>","DOI":"10.2460\/javma.230.4.541","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T12:57:48Z","timestamp":1171544268000},"page":"541-547","source":"Crossref","is-referenced-by-count":24,"title":["Keratoconjunctivitis sicca associated with administration of etodolac in dogs: 211 cases (1992\u20132002)"],"prefix":"10.2460","volume":"230","author":[{"given":"Gia","family":"Klauss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Giuliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecil P.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles M.","family":"Stuhr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy L.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff W.","family":"Tyler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsie E.","family":"Fitzgerald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra A.","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Veterinary ophthalmology","first-page":"583","article-title":"Diseases and surgery of the lacrimal secretory system","author":"Moore","year":"1999"},{"key":"ref2","series-title":"J Small Anim Pract","first-page":"121","article-title":"Keratoconjunctivitis sicca in the dog: a review of two hundred cases","volume":"26","author":"Sansom","year":"1985"},{"key":"ref3","series-title":"Vet Clin North Am Small Anim Pract","first-page":"583","article-title":"A new perspective on canine keratoconjunctivitis sicca. 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