{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:27:11Z","timestamp":1770218831966,"version":"3.49.0"},"reference-count":33,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2007,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Case Description<\/jats:bold>\u20141 dog evaluated because of inappetence and lameness of the left hind limb of 1 day's duration and 1 dog evaluated because of inappetence, fever, and lymphadenopathy of 2 weeks' duration.<\/jats:p>\n<jats:p><jats:bold>Clinical Findings<\/jats:bold>\u2014Histologic examination of excisional biopsy specimens from lymph nodes revealed pyogranulomatous lymphadenitis in both dogs. Quantitative real-time PCR assays detected <jats:italic>Bartonella henselae<\/jats:italic> DNA in blood samples and affected lymph node specimens from both dogs. Antibodies against <jats:italic>B henselae<\/jats:italic> were not detected via immunofluorescent antibody testing during active disease in either dog.<\/jats:p>\n<jats:p><jats:bold>Treatment and Outcome<\/jats:bold>\u20141 dog recovered after 6 weeks of treatment with doxycycline (5 mg\/kg [2.3 mg\/lb], PO, q 12 h), whereas the other dog recovered after receiving a combination of azithromycin (14.5 mg\/kg [6.6 mg\/lb], PO, q 24 h for 21 days), doxycycline (17.3 mg\/kg [7.9 mg\/lb], PO, q 24 h for 4 weeks), and immunosuppressive corticosteroid (prednisone [3 mg\/kg {1.4 mg\/lb}, PO, q 24 h], tapered by decreasing the daily dose by 25% every 2 weeks) treatment.<\/jats:p>\n<jats:p><jats:bold>Clinical Relevance<\/jats:bold>\u2014<jats:italic>B henselae<\/jats:italic> is implicated as a possible cause or a cofactor in the development of pyogranulomatous lymphadenitis in dogs. In dogs with pyogranulomatous lymphadenitis, immunofluorescent assays may not detect antibodies against <jats:italic>B henselae<\/jats:italic>. Molecular testing, including PCR assay of affected tissues, may provide an alternative diagnostic method for detection of <jats:italic>B henselae<\/jats:italic> DNA in pyogranulomatous lymph nodes.<\/jats:p>","DOI":"10.2460\/javma.230.5.681","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T02:20:46Z","timestamp":1172802046000},"page":"681-685","source":"Crossref","is-referenced-by-count":36,"title":["Detection of Bartonella henselae DNA in two dogs with pyogranulomatous lymphadenitis"],"prefix":"10.2460","volume":"230","author":[{"given":"Sofia C.","family":"Morales","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward B.","family":"Breitschwerdt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Washabau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilze","family":"Matise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo G.","family":"Maggi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashlee W.","family":"Duncan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Vet Res","first-page":"585","article-title":"Bartonella henselae IgG antibodies are prevalent in dogs from southeastern USA","volume":"35","author":"Solano-Gallego","year":"2004"},{"key":"ref2","series-title":"Emerg Infect Dis","first-page":"1894","article-title":"Bartonella henselae in porpoise blood","volume":"11","author":"Maggi","year":"2005"},{"key":"ref3","series-title":"J Clin 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