{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:09:10Z","timestamp":1764781750823,"version":"3.38.0"},"reference-count":32,"publisher":"American Veterinary Medical Association (AVMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2007,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Case Description<\/jats:bold>\u2014A 7-year-old domestic shorthair cat with a 2-month history of decreased appetite and weight loss was examined because of paraparesis of 1 week's duration that had progressed to paraplegia 3 days earlier.<\/jats:p>\n<jats:p><jats:bold>Clinical Findings<\/jats:bold>\u2014Neurologic examination revealed normo- to hyperreflexia and absence of deep pain sensation in the hind limbs and thoracolumbar spinal hyperesthesia. Neuro-anatomically, the lesion was located within the T3 through L3 spinal cord segments. Biochemical analysis and cytologic examination of CSF revealed no abnormalities. Radiography revealed narrowing of the T11-12 intervertebral disk space and intervertebral foramen suggestive of intervertebral disk disease. Myelography revealed an extradural mass centered at the T12-13 intervertebral disk space with extension over the dorsal surfaces of T11-13 and L1 vertebral bodies.<\/jats:p>\n<jats:p><jats:bold>Treatment and Outcome<\/jats:bold>\u2014A right-sided hemilaminectomy was performed over the T11-12, T12-13, and T13-L1 intervertebral disk spaces, and a space-occupying mass was revealed. Aerobic bacterial culture of samples of the mass yielded growth of a yeast organism after a 10-day incubation period; histologically, <jats:italic>Histoplasma capsulatum<\/jats:italic> was identified. Treatment with itraconazole was initiated. Nineteen days after surgery, superficial pain sensation and voluntary motor function were evident in both hind limbs. After approximately 3.5 months, the cat was ambulatory with sling assistance and had regained some ability to urinate voluntarily.<\/jats:p>\n<jats:p><jats:bold>Clinical Relevance<\/jats:bold>\u2014In cats with myelopathies that have no overt evidence of fungal dissemination, differential diagnoses should include CNS histoplasmosis. Although prognosis associated with fungal infections of the CNS is generally guarded, treatment is warranted and may have a positive outcome.<\/jats:p>","DOI":"10.2460\/javma.230.7.1018","type":"journal-article","created":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T13:34:34Z","timestamp":1175434474000},"page":"1018-1023","source":"Crossref","is-referenced-by-count":16,"title":["Treatment of thoracolumbar spinal cord compression associated with Histoplasma capsulatum infection in a cat"],"prefix":"10.2460","volume":"230","author":[{"given":"Arathi","family":"Vinayak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon C.","family":"Kerwin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy R.","family":"Pool","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Infectious diseases of the dog and cat","first-page":"378","article-title":"Histoplasmosis","author":"Wolf","year":"1998"},{"key":"ref2","series-title":"J Am Anim Hosp Assoc","first-page":"995","article-title":"Feline histoplasmosis: a literature review and retrospective study of 20 new cases","volume":"20","author":"Wolf","year":"1984"},{"key":"ref3","series-title":"Comp Vet Med Pract Vet","first-page":"1223","article-title":"Feline disseminated histoplasmosis","volume":"11","author":"Clinkenbeard","year":"1989"},{"key":"ref4","series-title":"J Am Anim Hosp Assoc","first-page":"380","article-title":"Deep mycotic infections in cats","volume":"32","author":"Davies","year":"1996"},{"key":"ref5","series-title":"Textbook of veterinary internal medicine","first-page":"341","article-title":"Deep mycotic diseases","author":"Wolf","year":"1989"},{"key":"ref6","series-title":"Vet Radiol","first-page":"34","article-title":"The radiographic appearance of pulmonary histoplasmosis in the cat","volume":"28","author":"Wolf","year":"1987"},{"key":"ref7","series-title":"Infectious diseases of the dog and cat","first-page":"576","article-title":"Histoplasmosis","author":"Greene","year":"2006"},{"key":"ref8","series-title":"J Am Vet Med Assoc","first-page":"1445","article-title":"Disseminated histoplasmosis in cats: 12 cases (1981\u20131986)","volume":"190","author":"Clinkenbeard","year":"1987"},{"key":"ref9","series-title":"J Am Anim Hosp Assoc","first-page":"119","article-title":"Pancytopenia associated with disseminated histoplasmosis in a cat","volume":"20","author":"Gabbert","year":"1984"},{"key":"ref10","series-title":"ASM News","first-page":"599","article-title":"Histoplasma capsulatum: darling of the river valleys","volume":"63","author":"Deepe","year":"1997"},{"key":"ref11","series-title":"Vet Clin Pathol","first-page":"122","article-title":"Diagnosis of histoplasmosis in a dog by cytologic examination of CSF","volume":"21","author":"Meadows","year":"1992"},{"key":"ref12","series-title":"Am J Med","first-page":"278","article-title":"The course and prognosis of histoplasmosis","volume":"27","author":"Rubin","year":"1959"},{"key":"ref13","series-title":"Medicine (Baltimore)","first-page":"244","article-title":"Histoplasma capsulatum infections of the central nervous system. 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