{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T21:37:31Z","timestamp":1778708251860,"version":"3.51.4"},"reference-count":36,"publisher":"American Veterinary Medical Association (AVMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2007,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To determine whether treatment with a preparation of <jats:italic>Propionibacterium acnes<\/jats:italic> would improve pregnancy and live foal rates in mares with persistent endometritis.<\/jats:p>\n<jats:p><jats:bold>Design<\/jats:bold>\u2014Randomized placebo-controlled clinical trial.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u201495 mares with a cytologic diagnosis of persistent endometritis.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Mares were treated with <jats:italic>P acnes<\/jats:italic> or placebo (both administered IV) on days 0, 2, and 6. No attempt was made to alter additional treatments administered by attending veterinarians. Information on breeding history, physical examination findings, results of cytologic examination and microbial culture of uterine samples, additional treatments administered, breeding dates, results of pregnancy examinations, whether a live foal was produced, and reactions to treatment was recorded.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014In multivariate logistic regression models, mare age, year of entry into the study, and first breeding within 8 days after first treatment with <jats:italic>P acnes<\/jats:italic> or placebo were significantly associated with pregnancy. Fewer number of cycles bred and younger age were significantly associated with delivery of a live foal in a separate multivariate analysis. Results of multivariate logistic regression modeling indicated that mares treated with <jats:italic>P acnes<\/jats:italic> were more likely to become pregnant and to deliver a live foal, compared with placebo-treated controls.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014IV administration of <jats:italic>P acnes<\/jats:italic> as an adjunct to conventional treatments in mares with a cytologic diagnosis of persistent endometritis improved pregnancy and live foal rates. The optimal effect was detected in mares bred during the interval extending from 2 days before to 8 days after first treatment with <jats:italic>P acnes<\/jats:italic>.<\/jats:p>","DOI":"10.2460\/javma.231.1.107","type":"journal-article","created":{"date-parts":[[2007,7,2]],"date-time":"2007-07-02T14:28:29Z","timestamp":1183386509000},"page":"107-113","source":"Crossref","is-referenced-by-count":19,"title":["Effect of adjunctive treatment with intravenously administered Propionibacterium acnes on reproductive performance in mares with persistent endometritis"],"prefix":"10.2460","volume":"231","author":[{"given":"Barton W.","family":"Rohrbach","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter C.","family":"Sheerin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles 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