{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:32:44Z","timestamp":1790213564421,"version":"4.1.0"},"reference-count":25,"publisher":"American Veterinary Medical Association (AVMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2007,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Case Description<\/jats:bold>\u2014A 6.5-year-old female eastern black and white colobus monkey (<jats:italic>Colobus guereza<\/jats:italic>) was evaluated after acute onset of ataxia and inappetence.<\/jats:p>\n<jats:p><jats:bold>Clinical Findings<\/jats:bold>\u2014The monkey was ataxic and lethargic, but no other abnormalities were detected via physical examination, radiography, or clinicopathologic analyses. During the next 2 days, the monkey's clinical condition deteriorated, and its WBC count decreased dramatically. Cytologic examination of a CSF sample revealed marked lymphohistiocytic inflammation.<\/jats:p>\n<jats:p><jats:bold>Treatment and Outcome<\/jats:bold>\u2014Despite supportive care, the monkey became apneic; after 20 hours of mechanical ventilation, fatal cardiac arrest occurred. At necropsy, numerous petechiae were detected within the white matter tracts of the brain; microscopic lesions of multifocal necrosis and hemorrhage with intranuclear inclusions identified in the brain and adrenal glands were consistent with an acute herpesvirus infection. A specific diagnosis of herpesvirus papio-2 (HVP-2) infection was made on the basis of results of serologic testing; PCR assay of tissue specimens; live virus isolation from the lungs; and immunohistochemical identification of the virus within brain, spinal cord, and adrenal gland lesions. Via phylogenetic tree analysis, the colobus HVP-2 isolate was grouped with neuroinvasive strains of the virus. The virus was most likely transmitted to the colobus monkey through toys shared with a nearby colony of baboons (the natural host of HVP-2).<\/jats:p>\n<jats:p><jats:bold>Clinical Relevance<\/jats:bold>\u2014To the authors' knowledge, this is the first reported case of natural transmission of HVP-2 to a nonhost species. Infection with HVP-2 should be a differential diagnosis for acute encephalopathy in primate monkeys and humans, particularly following exposure to baboons.<\/jats:p>","DOI":"10.2460\/javma.231.12.1878","type":"journal-article","created":{"date-parts":[[2007,12,15]],"date-time":"2007-12-15T18:06:02Z","timestamp":1197741962000},"page":"1878-1883","source":"Crossref","is-referenced-by-count":8,"title":["Naturally transmitted herpesvirus papio-2 infection in a black and white colobus monkey"],"prefix":"10.2460","volume":"231","author":[{"given":"Brigid V.","family":"Troan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila","family":"Perelygina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Patrusheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud J. van","family":"Wettere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia K.","family":"Hilliard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Loomis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan S. De","family":"Voe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"J Virol Methods","first-page":"245","article-title":"Quantitative real-time PCR for detection of monkey B virus (Cercopithecine herpesvirus 1) in clinical samples","volume":"109","author":"Perelygina","year":"2003"},{"key":"ref2","series-title":"J Virol","first-page":"8950","article-title":"Herpes simplex virus inhibits apoptosis through the action of two genes, Us5 and Us3","volume":"73","author":"Jerome","year":"1999"},{"key":"ref3","series-title":"J Virol","first-page":"10731","article-title":"Pathogenicity of different baboon herpesvirus papio 2 isolates is characterized by either extreme neurovirulence or complete apathogenicity","volume":"77","author":"Rogers","year":"2003"},{"key":"ref4","series-title":"J Virol Methods","first-page":"99","article-title":"ELISA for detection of group-common and virus-specific 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herpesvirus from trigeminal ganglia of normal baboons","volume":"28","author":"Kalter","year":"1978"},{"key":"ref14","series-title":"J Med Primatol","first-page":"52","article-title":"Herpesviral pneumonia and septicemia in two infant Gelada baboons (Theropithecus gelada)","volume":"11","author":"Ochoa","year":"1982"},{"key":"ref15","series-title":"J Am Assoc Lab Anim Sci","first-page":"64","article-title":"A naturally occurring fatal case of herpesvirus papio 2 pneumonia in an infant baboon (Papio hamadryas anubis)","volume":"45","author":"Wolf","year":"2006"},{"key":"ref16","series-title":"Infect Agents Dis","first-page":"55","article-title":"The simian herpesviruses","volume":"4","author":"Eberle","year":"1995"},{"key":"ref17","series-title":"Fields virology","first-page":"2835","article-title":"Cercopithecine herpesvirus (B virus)","author":"Whitley","year":"2001"},{"key":"ref18","series-title":"J Comp Pathol","first-page":"76","article-title":"Fatal herpes simplex infection in a 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