{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:52:11Z","timestamp":1760921531269,"version":"3.38.0"},"reference-count":12,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2007,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Case Description<\/jats:bold>\u2014A 5-year-old male German Shepherd Dog was evaluated because of a 5-month history of progressive lethargy, weight loss, and heart failure.<\/jats:p>\n<jats:p><jats:bold>Clinical Findings<\/jats:bold>\u2014On physical examination, bounding femoral pulses and systolic and diastolic murmurs were detected. Echocardiography revealed severe aortic valve insufficiency (AVI) and a large vegetative lesion on the aortic valve consistent with aortic valve endocarditis. The AVI velocity profile half-time was 130 milliseconds; the calculated peak systolic pressure gradient across the aortic valve was 64 mm Hg. Left ventricular diameter during diastole was 63.6 mm (predicted range, 40.2 to 42 mm) and during systole was 42.9 mm (predicted range, 25.4 to 27 mm). Systolic, diastolic, and mean arterial blood pressures were 120, 43, and 65 mm Hg, respectively.<\/jats:p>\n<jats:p><jats:bold>Treatment and Outcome<\/jats:bold>\u2014To palliate severe AVI, the descending aorta was occluded (duration, 16.75 minutes) and heterotopic implantation of a porcine bioprosthetic heart valve in that vessel was performed. After surgery, systolic, diastolic, and mean arterial blood pressures were 115, 30, and 61 mm Hg, respectively, in the forelimb and 110, 62, and 77 mm Hg, respectively, in the hind limb. Within 6 months, the AVI velocity profile half-time had increased to 210 milliseconds, indicating diminished severity of AVI. After 24 months, the dog was able to engage in vigorous exercise; no pulmonary edema had developed since surgery.<\/jats:p>\n<jats:p><jats:bold>Clinical Relevance<\/jats:bold>\u2014Heterotopic bioprosthetic heart valve implantation into the descending aorta during brief aortic occlusion appears feasible in dogs and may provide substantial palliation for dogs with severe AVI.<\/jats:p>","DOI":"10.2460\/javma.231.5.727","type":"journal-article","created":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T15:04:43Z","timestamp":1188659083000},"page":"727-730","source":"Crossref","is-referenced-by-count":7,"title":["Heterotopic implantation of a porcine bioprosthetic heart valve in a dog with aortic valve endocarditis"],"prefix":"10.2460","volume":"231","author":[{"given":"Shiori","family":"Arai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonnie D.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukari","family":"Miyake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"June A.","family":"Boon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Christopher","family":"Orton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Cardiol Clin Ann Drug Ther","first-page":"141","article-title":"Current recommendations for warfarin therapy","volume":"2","author":"Triplett","year":"1998"},{"key":"ref2","series-title":"J Am Vet Med Assoc","first-page":"570","article-title":"Endocarditis of the aortic valve in the dog","volume":"184","author":"Sisson","year":"1984"},{"key":"ref3","series-title":"J Am Vet Med Assoc","first-page":"1080","article-title":"Valvular bacterial endocarditis in the dog","volume":"180","author":"Calvert","year":"1982"},{"key":"ref4","series-title":"Ann Thorac Surg","first-page":"1218","article-title":"Hufnagel revisited: a descending thoracic aortic valve to treat prosthetic valve insufficiency","volume":"55","author":"Cale","year":"1993"},{"key":"ref5","series-title":"J Heart Valve Dis","first-page":"166","article-title":"Mechanical aortic valve replacement: long-term outcomes in children","volume":"14","author":"Shanmugam","year":"2005"},{"key":"ref6","series-title":"J Thorac Cardiovasc Surg","first-page":"268","article-title":"Late results of heart valve replacement with the Hancock II bioprosthesis","volume":"121","author":"David","year":"2001"},{"key":"ref7","series-title":"Heart Lung Circ","first-page":"41","article-title":"Allograft aortic valve replacement in the adult: a review","volume":"13","author":"Yap","year":"2004"},{"key":"ref8","series-title":"Surgery","first-page":"673","article-title":"Surgical correction of aortic insufficiency","volume":"35","author":"Hufnagel","year":"1954"},{"key":"ref9","series-title":"J Thorac Cardiovasc Surg","first-page":"900","article-title":"Late follow-up of ball-valve prostheses in the descending thoracic aorta","volume":"72","author":"Hufnagel","year":"1976"},{"key":"ref10","series-title":"The practice of clinical echocardioraphy","first-page":"367","article-title":"Quantitation of valvular regurgitation: beyond color flow mapping","author":"Heinle","year":"2002"},{"key":"ref11","series-title":"J Am Vet Med Assoc","first-page":"1941","article-title":"Evaluation of techniques and outcomes of mitral valve repair in dogs","volume":"224","author":"Griffiths","year":"2004"},{"key":"ref12","series-title":"J Am Vet Med Assoc","first-page":"1508","article-title":"Technique and outcome of mitral valve replacement in dogs","volume":"226","author":"Orton","year":"2005"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/231\/5\/javma.231.5.727.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/231\/5\/javma.231.5.727.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/231\/5\/javma.231.5.727.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T14:04:49Z","timestamp":1741356289000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/231\/5\/javma.231.5.727.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9,1]]},"references-count":12,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.2460\/javma.231.5.727","relation":{},"ISSN":["0003-1488"],"issn-type":[{"type":"print","value":"0003-1488"}],"subject":[],"published":{"date-parts":[[2007,9,1]]}}}