{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:17:29Z","timestamp":1778797049956,"version":"3.51.4"},"reference-count":18,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2007,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To estimate the prevalence of polysaccharide storage myopathy (PSSM) among Quarter Horses in the United States and evaluate possible relationships between muscle glycogen concentration, turnout time, and exercise level.<\/jats:p>\n<jats:p><jats:bold>Design<\/jats:bold>\u2014Cross-sectional study.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u2014164 overtly healthy Quarter Horses &gt; 2 years old from 5 states.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Horses with a history of exertional rhabdomyolysis or any other muscular disease were excluded. Muscle biopsy specimens were examined histologically for evidence of PSSM and were submitted for determination of muscle glycogen concentration. A diagnosis of PSSM was made if amylase-resistant inclusions that stained with periodic acid\u2013Schiff stain were detected.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014Prevalences of PSSM on the 2 farms with a history of PSSM were 20% (1\/5) and 40.7% (11\/27); mean prevalence for the other 4 farms was 6.1% (8\/132). Sex was not significantly associated with a diagnosis of PSSM, and age was not significantly different between horses with and without PSSM. Total histologic score, serum creatine kinase ac-tivity, and muscle glycogen concentration were significantly higher in horses with PSSM than in horses without.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results suggested that the prevalence of PSSM among overtly healthy Quarter Horses in the United States is likely to be between 6% and 12%.<\/jats:p>","DOI":"10.2460\/javma.231.5.746","type":"journal-article","created":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T15:04:43Z","timestamp":1188659083000},"page":"746-750","source":"Crossref","is-referenced-by-count":25,"title":["Estimated prevalence of polysaccharide storage myopathy among overtly healthy Quarter Horses in the United States"],"prefix":"10.2460","volume":"231","author":[{"given":"Molly E.","family":"McCue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie J.","family":"Valberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Neuromuscul Disord","first-page":"351","article-title":"Polysaccharide storage myopathy associated with recurrent exertional rhabdomyolysis in horses","volume":"2","author":"Valberg","year":"1992"},{"key":"ref2","series-title":"Am J Vet Res","first-page":"1319","article-title":"Epidemiologic characteristics and management of polysaccharide storage myopathy in Quarter Horses","volume":"64","author":"Firshman","year":"2003"},{"key":"ref3","series-title":"J Vet Intern Med","first-page":"581","article-title":"Developmental onset of polysaccharide storage myopathy in 4 Quarter Horse foals","volume":"16","author":"De La Corte","year":"2002"},{"key":"ref4","series-title":"Am J Vet Res","first-page":"286","article-title":"Familial basis of exertional rhabdomyolysis in Quarter Horse-related 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myopathy","volume":"66","author":"Firshman","year":"2005"},{"key":"ref13","series-title":"Am J Vet Res","first-page":"839","article-title":"Effects of submaximal exercise on adenine nucleotide concentrations in skeletal muscle fibers of horses with polysaccharide storage myopathy","volume":"66","author":"Annandale","year":"2005"},{"key":"ref14","series-title":"J Vet Intern Med","first-page":"887","article-title":"The effect of varying dietary starch and fat content on serum creatine kinase activity and substrate availability in equine polysaccharide storage myopathy","volume":"18","author":"Ribeiro","year":"2004"},{"key":"ref15","series-title":"J Am Vet Med Assoc","first-page":"1537","article-title":"Role of dietary carbohydrate and fat in horses with equine polysaccharide storage myopathy","volume":"219","author":"Valentine","year":"2001"},{"key":"ref16","series-title":"A flexible system of enzymatic analysis","author":"Lowry","year":"1972"},{"key":"ref17","series-title":"Large animal internal medicine","first-page":"1272","article-title":"Diseases of muscle","author":"Valberg","year":"2002"},{"key":"ref18","series-title":"The athletic horse","first-page":"145","article-title":"Muscle anatomy: adaptations to exercise and training","author":"Snow","year":"1994"}],"container-title":["Journal of the American Veterinary Medical 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