{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T20:02:34Z","timestamp":1784750554819,"version":"3.55.0"},"reference-count":12,"publisher":"American Veterinary Medical Association (AVMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2007,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To determine the relationship between a circumferential femoral head osteophyte (CFHO) and osteoarthritis characteristic of canine hip dysplasia, and to ascertain whether CFHO, like osteoarthritis, varies between diet-restricted and control-fed dogs.<\/jats:p>\n<jats:p><jats:bold>Design<\/jats:bold>\u2014Longitudinal cohort study.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u201448 Labrador Retrievers.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Dogs were paired by size, sex, and litter and assigned to 1 of 2 equal groups at 2 months of age. The control-fed group was fed ad libitum, and the diet-restricted group was fed 25% less on a pairwise basis of the same diet for life. The dogs' hip joints were radiographed yearly for life. Each radiograph was evaluated for radiographic signs of osteoarthritis characteristic of hip dysplasia and for the presence and severity of a CFHO.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u201441 of the 48 (85.4%) dogs had a CFHO, which was detected at a median age of 5.4 years, and 33 of those 41 (80.5%) developed radiographic evidence of osteoarthritis. Nineteen (79.2%) dogs in the diet-restricted group and 22 (91.7%) in the control-fed group had a CFHO at a median age of 9 and 3 years, respectively. Of the dogs with a CFHO, 12 (63.2%) in the diet-restricted group and 20 (90.0%) in the control-fed group developed radiographic evidence of osteoarthritis characteristic of hip dysplasia at a median age of 11 and 6.5 years, respectively.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results indicated a relationship between the CFHO and subsequent development of radiographic signs of osteoarthritis. If a CFHO is present in Labrador Retrievers, it might be considered an early indicator of osteoarthritis.<\/jats:p>","DOI":"10.2460\/javma.231.6.889","type":"journal-article","created":{"date-parts":[[2007,9,15]],"date-time":"2007-09-15T19:24:15Z","timestamp":1189884255000},"page":"889-892","source":"Crossref","is-referenced-by-count":23,"title":["Evaluation of a circumferential femoral head osteophyte as an early indicator of osteoarthritis characteristic of canine hip dysplasia in dogs"],"prefix":"10.2460","volume":"231","author":[{"given":"Stephanie D.","family":"Szabo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryl N.","family":"Biery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis F.","family":"Lawler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances S.","family":"Shofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle Y.","family":"Powers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D.","family":"Kealy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail K.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Textbook of small animal surgery","first-page":"2009","article-title":"Hip dysplasia: pathogenesis","author":"Todhunter","year":"2003"},{"key":"ref2","series-title":"J Am Vet Med Assoc","first-page":"1463","article-title":"The joint capsule and joint laxity in dogs with hip dysplasia","volume":"210","author":"Madsen","year":"1997"},{"key":"ref3","series-title":"Compend Contin Educ Pract Vet","first-page":"526","article-title":"Canine hip dysplasia: the disease and its diagnosis","volume":"24","author":"Kapatkin","year":"2002"},{"key":"ref4","series-title":"J Am Vet Med Assoc","first-page":"222","article-title":"Five-year longitudinal study on limited food consumption and development of osteoarthritis in coxofemoral joints of dogs","volume":"210","author":"Kealy","year":"1997"},{"key":"ref5","series-title":"Am J Vet Res","first-page":"1021","article-title":"Coxofemoral joint laxity from distraction radiography and its contemporaneous and prospective correlation with laxity, subjective score, and evidence of degenerative joint disease from conventional hip-extended radiography in dogs","volume":"54","author":"Smith","year":"1993"},{"key":"ref6","series-title":"J Am Vet Med Assoc","first-page":"690","article-title":"Lifelong diet restriction and radiographic evidence of osteoarthritis of the hip joint in dogs","volume":"229","author":"Smith","year":"2006"},{"key":"ref7","series-title":"J Am Vet Med Assoc","first-page":"857","article-title":"Effects of limited food consumption on the incidence of hip dysplasia in growing dogs","volume":"201","author":"Kealy","year":"1992"},{"key":"ref8","series-title":"J Am Vet Med Assoc","first-page":"1678","article-title":"Evaluation of the effect of limited food consumption on radiographic evidence of osteoarthritis in dogs","volume":"217","author":"Kealy","year":"2000"},{"key":"ref9","series-title":"Vet Pathol","first-page":"265","article-title":"The dysplastic hip joint: radiologic and histologic development","volume":"12","author":"Riser","year":"1975"},{"key":"ref10","series-title":"Vet Radiol","first-page":"2","article-title":"Canine hip dysplasia: significance of early bony spurring","volume":"28","author":"Morgan","year":"1987"},{"key":"ref11","series-title":"J Am Vet Med Assoc","first-page":"472","article-title":"Evaluation of a radiographic caudolateral curvilinear osteophyte on the femoral neck and its relationship to degenerative joint disease and distraction index in dogs","volume":"220","author":"Mayhew","year":"2002"},{"key":"ref12","series-title":"J Am Vet Med Assoc","first-page":"233","article-title":"Use of the caudolateral curvilinear osteophyte as an early marker for future development of osteoarthritis associated with hip dysplasia in dogs","volume":"225","author":"Powers","year":"2004"}],"container-title":["Journal of the American Veterinary Medical 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