{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:11:09Z","timestamp":1776816669831,"version":"3.51.2"},"reference-count":28,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2007,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Case Description<\/jats:bold>\u2014An 8-year-old domestic shorthair cat was evaluated because of signs of depression, circling, and visual deficits.<\/jats:p>\n<jats:p><jats:bold>Clinical Findings<\/jats:bold>\u2014The cat had no cutaneous lesions, and results of an ophthalmologic examination and thoracic radiography were within reference limits. Computed tomography of the brain revealed a mass lesion involving the right parietal, temporal, and occipital lobes; the mass was in broad-based contact with the skull and smoothly marginated and had strong homogenous enhancement after contrast agent administration. During craniectomy, samples of the mass were collected for cytologic and histopathologic evaluations and microbial culture. A diagnosis of <jats:italic>Blastomyces dermatitidis<\/jats:italic>\u2014associated meningoencephalitis with secondary pyogranulomatous inflammation was made.<\/jats:p>\n<jats:p><jats:bold>Treatment and Outcome<\/jats:bold>\u2014Amphotericin B (0.25 mg\/kg [0.11 mg\/lb], IV) was administered on alternate days (cumulative dose, 1.75 mg\/kg [0.8 mg\/lb]). To minimize the risk of nephrotoxicosis, assessments of serum biochemical variables (urea nitrogen and creatinine concentrations) and urinalyses were performed at intervals. The third dose of amphotericin B was postponed 48 hours because the cat became azotemic. The cat subsequently received fluconazole (10 mg\/kg [4.5 mg\/lb], PO, q 12 h) for 5.5 months. Six months after discontinuation of that treatment, the cat appeared healthy and had no signs of relapse.<\/jats:p>\n<jats:p><jats:bold>Clinical Relevance<\/jats:bold>\u2014Brain infection with <jats:italic>B dermatitidis<\/jats:italic> is typically associated with widespread disseminated disease. The cat of this report had no evidence of systemic disease. Blastomycosis of the CNS should be considered as a differential diagnosis for brain lesions in cats from areas in which <jats:italic>B dermatitidis<\/jats:italic> is endemic.<\/jats:p>","DOI":"10.2460\/javma.231.8.1210","type":"journal-article","created":{"date-parts":[[2007,10,15]],"date-time":"2007-10-15T14:30:48Z","timestamp":1192458648000},"page":"1210-1214","source":"Crossref","is-referenced-by-count":15,"title":["Cerebral Blastomyces dermatitidis infection in a cat"],"prefix":"10.2460","volume":"231","author":[{"given":"Jo R.","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred M.","family":"Legendre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William B.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casey J.","family":"LeBlanc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathy","family":"Lamkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"Avenell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan S.","family":"Wall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silke","family":"Hecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Infectious diseases of the cat and dog.","first-page":"569","article-title":"Blastomycosis","author":"Legendre","year":"2006"},{"key":"ref2","series-title":"Clin Tech Small Anim Pract","first-page":"233","article-title":"Br\u00f6mel C, Sykes JE. Epidemiology, diagnosis and treatment of blastomycosis in dogs and cats","volume":"20","year":"2005"},{"key":"ref3","series-title":"J Am Anim Hosp Assoc","first-page":"417","article-title":"Feline blastomycosis: a report of three cases and literature review (1961 to 1988)","volume":"26","author":"Miller","year":"1990"},{"key":"ref4","series-title":"J Am Anim Hosp Assoc","first-page":"380","article-title":"Deep mycotic infections in cats","volume":"32","author":"Davies","year":"1996"},{"key":"ref5","series-title":"J Am Vet Med Assoc","first-page":"96","article-title":"Clinical aspects of natural infection with Blastomyces dermatitidis in cats: 8 cases (1991\u20132005)","volume":"229","author":"Gilor","year":"2006"},{"key":"ref6","series-title":"Clin Tech Small Anim Pract","first-page":"212","article-title":"Fungal infections of the central nervous system in the dog and cat","volume":"20","author":"Lavely","year":"2005"},{"key":"ref7","series-title":"J Vet Intern Med","first-page":"850","article-title":"Feline intracranial neoplasia: retrospective review of 160 cases (1985\u20132001)","volume":"17","author":"Troxel","year":"2003"},{"key":"ref8","series-title":"Veterinary neuroanatomy and clinical neurology","first-page":"365","article-title":"De Lahunta A. Small animal neurologic examination and index of diseases of the nervous system","year":"1983"},{"key":"ref9","series-title":"J Am Vet Med Assoc","first-page":"1224","article-title":"Meningiomas in cats: a retrospective clinical study of 36 cases","volume":"174","author":"Nafe","year":"1979"},{"key":"ref10","series-title":"Am J Vet Res","first-page":"1030","article-title":"Studies on meningiomas in cats","volume":"22","author":"Luginbuhl","year":"1961"},{"key":"ref11","series-title":"J Am Anim Hosp Assoc","first-page":"333","article-title":"Cerebral meningioma in the cat: diagnosis and surgical treatment of ten cases","volume":"20","author":"Lawson","year":"1984"},{"key":"ref12","series-title":"Clin Tech Small Anim Pract","first-page":"112","article-title":"Intracranial neoplasia","volume":"14","author":"Kraft","year":"1999"},{"key":"ref13","series-title":"J Vet Intern Med","first-page":"176","article-title":"Magnetic resonance imaging features of feline intracranial neoplasia: retrospective analysis of 46 cats","volume":"18","author":"Troxel","year":"2004"},{"key":"ref14","series-title":"Clin Tech Small Anim Pract","first-page":"125","article-title":"Nonneoplastic disorders of the brain","volume":"14","author":"Thomas","year":"1999"},{"key":"ref15","series-title":"Medicine (Baltimore)","first-page":"224","article-title":"Intracranial blastomycoma","volume":"66","author":"Roos","year":"1987"},{"key":"ref16","series-title":"Vet Radiol Ultrasound","first-page":"16","article-title":"CT findings of intracranial blastomycosis in a dog","volume":"43","author":"Saito","year":"2002"},{"key":"ref17","series-title":"J Am Vet Med Assoc","first-page":"479","article-title":"Possible transmission of Blastomycosis dermatitidis via culture specimen","volume":"210","author":"Cot\u00e9","year":"1997"},{"key":"ref18","series-title":"Am J Vet Res","first-page":"2109","article-title":"Evaluation of agar-gel immunodiffusion test in the diagnosis of canine blastomycosis","volume":"41","author":"Legendre","year":"1980"},{"key":"ref19","series-title":"Mycopathologia","first-page":"137","article-title":"Blastomyces dermatitidis antigen detection in urine specimens from dogs with blastomycosis using a competitive binding inhibition ELISA","volume":"160","author":"Shurley","year":"2005"},{"key":"ref20","series-title":"J Clin Microbiol","first-page":"4873","article-title":"Antigen assay with the potential to aid in diagnosis of blastomycosis","volume":"42","author":"Durkin","year":"2004"},{"key":"ref21","series-title":"Neurol Clinic","first-page":"761","article-title":"Fungal infections of the central nervous system","volume":"17","author":"Davis","year":"1999"},{"key":"ref22","series-title":"J Vet Intern Med","first-page":"365","article-title":"Treatment of blastomycosis with itraconazole in 112 dogs","volume":"10","author":"Legendre","year":"1996"},{"key":"ref23","series-title":"J Am Vet Med Assoc","first-page":"570","article-title":"Blastomycosis in cats: five cases (1979\u20131986)","volume":"193","author":"Breider","year":"1988"},{"key":"ref24","series-title":"Current veterinary therapy IX","first-page":"560","article-title":"Antifungal agents in dermatology","author":"Foil","year":"1986"},{"key":"ref25","series-title":"Clin Positron Imaging","first-page":"261","article-title":"FDG accumulation in disseminated Blastomycoses dermatitidis in a dog","volume":"1","author":"Smith","year":"1998"},{"key":"ref26","series-title":"Clin Positron Imaging","first-page":"217","article-title":"Fluorine-18 fluorodeoxyglucose accumulation in Blastomyces dermatitidis-associated inflammation in a dog","volume":"2","author":"Matwichuk","year":"1999"},{"key":"ref27","series-title":"Mol Imaging Biol","first-page":"201","article-title":"Characterization of uptake of 2-deoxy-2-[18F] fluoro-D-glucose by fungal-associated inflammation: the standardized uptake value is greater for lesions of blastomycosis than for lymphoma in dogs with naturally occurring disease","volume":"4","author":"Bassett","year":"2002"},{"key":"ref28","series-title":"Semin Nucl Med","first-page":"313","article-title":"Evolving role of positron emission tomography in the management of patients with inflammatory and other benign diseases","volume":"34","author":"El-Haddad","year":"2004"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/231\/8\/javma.231.8.1210.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/231\/8\/javma.231.8.1210.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/231\/8\/javma.231.8.1210.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T14:04:48Z","timestamp":1741356288000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/231\/8\/javma.231.8.1210.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,15]]},"references-count":28,"journal-issue":{"issue":"8"},"URL":"https:\/\/doi.org\/10.2460\/javma.231.8.1210","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2007,10,15]]}}}