{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T06:44:59Z","timestamp":1794033899302,"version":"4.8.0"},"reference-count":35,"publisher":"American Veterinary Medical Association (AVMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2008,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To determine whether serum N-terminal pro-B-type natriuretic (NT-proBNP) concentration could be used to identify cardiac disease in dogs and to assess disease severity in affected dogs.<\/jats:p>\n<jats:p><jats:bold>Design<\/jats:bold>\u2014Cross-sectional study.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u2014119 dogs with mitral valve disease, 18 dogs with dilated cardiomyopathy, and 40 healthy control dogs.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Serum NT-proBNP concentration was measured with an ELISA validated for use in dogs. Results of physical examination, thoracic radiography, echocardiography, and serum biochemical analyses were recorded for dogs with cardiac disease.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014Serum NT-proBNP concentration was significantly higher in dogs with cardiac disease than in control dogs, and a serum NT-proBNP concentration &gt; 445 pmol\/L could be used to discriminate dogs with cardiac disease from control dogs with a sensitivity of 83.2% and specificity of 90.0%. In dogs with cardiac disease, serum NT-proBNP concentration was correlated with heart rate, respiratory rate, echocardiographic heart size, and renal function. For dogs with cardiac disease, serum NT-proBNP concentration could be used to discriminate dogs with and without radiographic evidence of cardiomegaly and dogs with and without congestive heart failure.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results suggested that serum NT-proBNP concentration may be a useful adjunct clinical test for diagnosing cardiac disease in dogs and assessing the severity of disease in dogs with cardiac disease.<\/jats:p>","DOI":"10.2460\/javma.232.10.1496","type":"journal-article","created":{"date-parts":[[2008,5,15]],"date-time":"2008-05-15T12:31:17Z","timestamp":1210854677000},"page":"1496-1503","source":"Crossref","is-referenced-by-count":112,"title":["Clinical utility of serum N-terminal pro-B-type natriuretic peptide concentration for identifying cardiac disease in dogs and assessing disease severity"],"prefix":"10.2460","volume":"232","author":[{"given":"Mark A.","family":"Oyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip R.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Rush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Rozanski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Lesser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Am J Physiol","article-title":"Differential atrial and ventricular expression of myocardial BNP during evolution of heart failure","author":"Luchner","year":"1998"},{"key":"ref2","series-title":"Eur J Heart Fail","first-page":"787","article-title":"Anaemia and renal dysfunction are independently associated 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