{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:16:05Z","timestamp":1787170565222,"version":"build-2736575974"},"reference-count":23,"publisher":"American Veterinary Medical Association (AVMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2008,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Case Description<\/jats:bold>\n                    \u2014A 13-year-old female intact Moluccan cockatoo (\n                    <jats:italic>Cacatua moluccensis<\/jats:italic>\n                    ) was evaluated because of coelomic distention, presumed to be secondary to an abdominal hernia. The patient also had a history of rapid weight gain and polyuria and polydipsia.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Clinical Findings<\/jats:bold>\n                    \u2014Ultrasonography was used to confirm the existence of a pseudohernia that appeared to contain the small intestines, pancreas, and reproductive tract. Results of plasma biochemical analysis revealed hyperglycemia, hypophosphatemia, and high nonfasting bile acid concentrations and aspartate aminotransferase activity. A CBC revealed a relative heterophilia with a concomitant lymphopenia and mild monocytosis. Histologic evaluation of a liver biopsy specimen indicated chronic hepatic lipidosis. Despite a strong clinical suspicion of hyperadrenocorticism, ACTH stimulation test results were equivocal.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Treatment and Outcome<\/jats:bold>\n                    \u2014The pseudohernia was strengthened with a prolene mesh. Despite ongoing medical and surgical care, the patient developed complications associated with the herniorrhaphy and was euthanatized. The clinical suspicion of hyperadrenocorticism was confirmed on the basis of histologic evaluation of the pituitary gland by use of special stains.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Clinical Relevance<\/jats:bold>\n                    \u2014To our knowledge, pituitary-dependent hyperadrenocorticism has not been previously confirmed in Psittaciformes. The condition should be considered in birds with clinical signs consistent with those observed in mammals. For the cockatoo of this report, ACTH stimulation test results were equivocal and additional diagnostic tests should be developed for avian patients.\n                  <\/jats:p>","DOI":"10.2460\/javma.232.3.394","type":"journal-article","created":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T15:41:02Z","timestamp":1201880462000},"page":"394-398","source":"Crossref","is-referenced-by-count":11,"title":["Pituitary-dependent hyperadrenocorticism in a cockatoo"],"prefix":"10.2460","volume":"232","author":[{"given":"Simon R.","family":"Starkey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James K.","family":"Morrisey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer E.","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth L.","family":"Buckles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Textbook of veterinary internal medicine","first-page":"1592","article-title":"Hyperadrenocorticism","author":"Reusch","year":"2005"},{"key":"ref2","series-title":"Am J Vet Res","first-page":"1584","article-title":"Effect of exogenous ACTH on serum corticosterone and cortisol concentrations in the Moluccan cockatoo (Cacatua moluccensis)","volume":"46","author":"Walsh","year":"1985"},{"key":"ref3","series-title":"Pathology of pet and aviary birds","first-page":"121","article-title":"Endocrine system","author":"Schmidt","year":"2003"},{"key":"ref4","series-title":"Vet Clin North Am Small Anim Pract","first-page":"985","article-title":"Diagnosis of canine hyperadrenocorticism","volume":"31","author":"Behrend","year":"2001"},{"key":"ref5","series-title":"J Endocrinol Invest","first-page":"741","article-title":"Cyclic Cushing's disease with paradoxical response to dexamethasone","volume":"28","author":"Checchi","year":"2005"},{"key":"ref6","series-title":"Endocr J","first-page":"287","article-title":"Periodic secretion of adrenocorticotropin in a patient with Cushing's disease manifested during pregnancy","volume":"52","author":"Miyoshi","year":"2005"},{"key":"ref7","series-title":"Endocrinology","first-page":"70","article-title":"Adrenal sensitivity to adrenocorticotropin varies diurnally","volume":"109","author":"Kaneko","year":"1981"},{"key":"ref8","series-title":"Neuroendocrinology","first-page":"217","article-title":"Diurnal variations in responsiveness of the hypothalamo-pituitary-adrenocortical axis of the rat","volume":"40","author":"Nicholson","year":"1985"},{"key":"ref9","series-title":"Avian Dis","first-page":"453","article-title":"No evidence for diurnal variation in the responsiveness of the pituitary-adrenocortical axis of the pigeon (Columba livia domestica) to stimulation with 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(Nymphicus hollandicus)","volume":"6","author":"Curtis-Velasco","year":"1992"},{"key":"ref19","series-title":"J Avian Med Surg","first-page":"263","article-title":"Pituitary adenoma in an Amazon parrot","volume":"9","author":"Romagnano","year":"1995"},{"key":"ref20","series-title":"Cell Tissue Res","first-page":"219","article-title":"Adrenocortical response in the duck exposed to corticosteroid administration and salt loading","volume":"160","author":"Bhattacharyya","year":"1975"},{"key":"ref21","series-title":"Cell Tissue Res","first-page":"353","article-title":"Cytological differentiation of the interrenal tissue of the Japanese quail, Coturnix coturnix","volume":"208","author":"Mikami","year":"1980"},{"key":"ref22","series-title":"Avian medicine: principle and application","first-page":"582","article-title":"Endocrinology","author":"Lumeij","year":"1994"},{"issue":"suppl 1","key":"ref23","series-title":"Vet Q","first-page":"S111","article-title":"Hyperadrenocorticism caused by an 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