{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:50:40Z","timestamp":1789951840813,"version":"4.0.1"},"reference-count":23,"publisher":"American Veterinary Medical Association (AVMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2008,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To evaluate factors associated with response to treatment, remission duration, and survival in cats with low-grade lymphoma affecting various organ systems.<\/jats:p>\n<jats:p><jats:bold>Design<\/jats:bold>\u2014Retrospective case series.<\/jats:p>\n<jats:p><jats:bold>Sample Population<\/jats:bold>\u201441 cats with histologically confirmed low-grade lymphocytic lymphoma.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Medical records and biopsy specimens of cats with histologically confirmed low-grade lymphocytic lymphoma of various organ systems treated with prednisone and chlorambucil between 1995 and 2005 were reviewed. The Kaplan-Meier method was used to estimate remission duration and survival. Factors potentially associated with prognosis were compared.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014Common clinical signs were weight loss (83%), vomiting (73%), anorexia (66%), and diarrhea (58%). Seventy-eight percent of cats tested had low serum cobalamin concentrations. Lymphoma was confined to the gastrointestinal tract in 68% of cats. Fifty-six percent of cats achieved a complete response to treatment, and 39% achieved a partial response. Five percent of cats had no response. No association was found between any risk factors (including anatomic site) and response to treatment. Partial response was associated with shorter remission duration, compared with complete response; median remission duration was 428 days for cats achieving a partial response, compared with 897 days for cats achieving a complete response. No other factors were associated with remission duration. Overall median survival time was 704 days. No factors were significantly associated with survival time.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Most cats with lymphocytic lymphoma responded to treatment with prednisone and chlorambucil, and most factors evaluated were not associated with outcome.<\/jats:p>","DOI":"10.2460\/javma.232.3.405","type":"journal-article","created":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T20:41:02Z","timestamp":1201898462000},"page":"405-410","source":"Crossref","is-referenced-by-count":118,"title":["Outcome of cats with low-grade lymphocytic lymphoma: 41 cases (1995\u20132005)"],"prefix":"10.2460","volume":"232","author":[{"given":"Michael A.","family":"Kiselow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth M.","family":"Rassnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean P.","family":"McDonough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth W.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan K.","family":"Weinkle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hollis N.","family":"Erb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"J Vet Diagn Invest","first-page":"295","article-title":"The histologic classification of 602 cases of feline lymphoproliferative disease using the National Cancer Institute working formulation","volume":"12","author":"Valli","year":"2000"},{"key":"ref2","series-title":"J Am Vet Med Assoc","first-page":"1593","article-title":"Alimentary lymphoma in cats: 28 cases (1988\u20131993)","volume":"207","author":"Mahony","year":"1995"},{"key":"ref3","series-title":"Aust Vet J","first-page":"725","article-title":"Clinical and anatomical features of lymphosarcoma in 118 cats","volume":"76","author":"Gabor","year":"1998"},{"key":"ref4","series-title":"J Am Vet Med Assoc","first-page":"1118","article-title":"Response rates and survival times for cats with lymphoma treated with the University of Wisconsin-Madison chemotherapy protocol: 38 cases (1996\u20132003)","volume":"227","author":"Milner","year":"2005"},{"key":"ref5","series-title":"J Vet Intern Med","first-page":"326","article-title":"Feline epitheliotropic intestinal malignant lymphoma: 10 cases (1997\u20132000)","volume":"17","author":"Carreras","year":"2003"},{"key":"ref6","series-title":"J Vet Intern Med","first-page":"720","article-title":"bcl-2 and MIB-1 labeling indexes in cats with lymphoma","volume":"16","author":"Dank","year":"2002"},{"key":"ref7","series-title":"Eur J Comp Gastroenterol","first-page":"5","article-title":"Feline gastrointestinal lymphoma: 67 cases (1988\u20131996)","volume":"4","author":"Fondacaro","year":"1999"},{"key":"ref8","series-title":"Histological classification of hematopoietic tumors of domestic animals.","first-page":"39","author":"Valli","year":"2002"},{"key":"ref9","series-title":"Neoplastic hematopathology.","first-page":"773","article-title":"Ben-Ezra J. 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