{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:59:48Z","timestamp":1790672388813,"version":"4.1.0"},"reference-count":19,"publisher":"American Veterinary Medical Association (AVMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2008,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    \u2014To determine prevalence of splenic hemangiosarcoma in anemic dogs with a splenic mass and hemoperitoneum requiring a transfusion and to identify factors that could differentiate between dogs with hemangiosarcoma and dogs with other splenic masses at the time of hospital admission.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design<\/jats:bold>\n                    \u2014Retrospective case series.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Animals<\/jats:bold>\n                    \u201471 dogs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Procedures<\/jats:bold>\n                    \u2014Medical records, blood bank logs, and histologic reports of dogs with a splenic mass and hemoperitoneum that required a transfusion between 2003 and 2005 were reviewed. Dogs that received a transfusion of packed RBCs, were splenectomized, and had a definitive histologic diagnosis were included.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    \u2014Signalment of dogs was similar to that in other reports. Malignant splenic neoplasia was identified in 54 of 71 (76.1%) dogs, whereas 17 of 71 (23.9%) dogs had a benign splenic lesion. Of 54 dogs with malignant splenic neoplasia, 50 (92.6% [70.4% of all dogs]) had splenic hemangiosarcoma. In addition, dogs with splenic hemangiosarcoma had significantly lower total solids (TS) concentrations and platelet counts at admission. Finally, hemoperitoneum was strongly associated with a diagnosis of splenic hemangiosarcoma.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\n                    \u2014In this clinical population of dogs, prevalence of hemangiosarcoma was higher than in other studies. Dogs with hemangiosarcoma in this study had significantly lower TS concentrations and platelet counts at the time of admission, compared with values for dogs with other splenic masses. No other markers were useful in differentiating dogs with hemangiosarcoma. It is important to discuss the prevalence of and poor prognosis associated with hemangiosarcoma with owners when they are contemplating whether to proceed with treatment.\n                  <\/jats:p>","DOI":"10.2460\/javma.232.4.553","type":"journal-article","created":{"date-parts":[[2008,2,15]],"date-time":"2008-02-15T09:19:45Z","timestamp":1203067185000},"page":"553-558","source":"Crossref","is-referenced-by-count":100,"title":["Prevalence of hemangiosarcoma in anemic dogs with a splenic mass and hemoperitoneum requiring a transfusion: 71 cases (2003\u20132005)"],"prefix":"10.2460","volume":"232","author":[{"given":"Tara N.","family":"Hammond","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Anna","family":"Pesillo-Crosby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Small animal clinical oncology","first-page":"639","article-title":"Miscellaneous tumors","author":"MacEwen","year":"2001"},{"key":"ref2","series-title":"J Am Vet Med Assoc","first-page":"706","article-title":"Epidemiologic, clinical, pathologic, and prognostic characteristics of splenic hemangiosarcoma and splenic hematoma in dogs: 217 cases (1985)","volume":"193","author":"Prymak","year":"1988"},{"key":"ref3","series-title":"J Vet Intern Med","first-page":"160","article-title":"Splenomegaly in dogs","volume":"3","author":"Johnson","year":"1989"},{"key":"ref4","series-title":"J Am Vet Med Assoc","first-page":"829","article-title":"Prevalence, type, and importance of splenic diseases in dogs: 1,480 cases (1985\u20131989)","volume":"200","author":"Spangler","year":"1992"},{"key":"ref5","series-title":"J 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pathological diagnoses from 87 canine splenic biopsies","volume":"36","author":"Day","year":"1995"},{"key":"ref11","series-title":"Vet Pathol","first-page":"488","article-title":"Pathologic and prognostic characteristics of splenomegaly in dogs due to fibrohistiocytic nodules: 98 cases","volume":"35","author":"Spangler","year":"1998"},{"key":"ref12","series-title":"Vet Clin Small Anim","first-page":"135","article-title":"Cytology of the spleen","volume":"33","author":"Christopher","year":"2003"},{"key":"ref13","series-title":"J Vet Intern Med","first-page":"11","article-title":"Hemostatic abnormalities in dogs with hemangiosarcoma","volume":"5","author":"Hammer","year":"1991"},{"key":"ref14","series-title":"J Vet Intern Med","first-page":"400","article-title":"Thrombocytopenia associated with neoplasia in dogs","volume":"8","author":"Grindem","year":"1994"},{"key":"ref15","series-title":"J Am Vet Med Assoc","first-page":"1113","article-title":"Ultrasonographic features of splenic hemangiosarcoma in dogs: 18 cases (1980\u20131986)","volume":"192","author":"Wrigley","year":"1988"},{"key":"ref16","series-title":"Vet Radiol Ultrasound","first-page":"289","article-title":"Comparison between malignant and nonmalignant splenic masses in dogs using contrast-enhanced computed tomography","volume":"45","author":"Fife","year":"2004"},{"key":"ref17","series-title":"J Vet Intern Med","first-page":"330","article-title":"Magnetic resonance imaging of focal splenic and hepatic lesions in the dog","volume":"3","author":"Clifford","year":"2004"},{"key":"ref18","series-title":"J Am Anim Hosp Assoc","first-page":"518","article-title":"Acute nontraumatic hemoabdomen in the dog: a retrospective analysis of 39 cases (1987\u20132001)","volume":"39","author":"Pintar","year":"2003"},{"key":"ref19","series-title":"J Am Anim Hosp Assoc","first-page":"417","article-title":"Prognosis for dogs with stage I or II splenic hemangiosarcoma treated by splenectomy alone: 32 cases (1991\u20131993)","volume":"34","author":"Wood","year":"1998"}],"container-title":["Journal of the American Veterinary Medical 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