{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:17:49Z","timestamp":1784830669670,"version":"3.55.0"},"reference-count":20,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2008,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Case Description<\/jats:bold>\u2014A 5-month-old captive female striped skunk (<jats:italic>Mephitis mephitis<\/jats:italic>) was evaluated because of lethargy, signs of depression, azotemia, and erythema of the skin around the eyes.<\/jats:p>\n<jats:p><jats:bold>Clinical Findings<\/jats:bold>\u2014Antemortem diagnostic tests revealed renal disease but failed to identify an etiologic agent. A diagnosis of severe nonsuppurative interstitial nephritis was made on the basis of results of histologic examination of renal biopsy specimens.<\/jats:p>\n<jats:p><jats:bold>Treatment and Outcome<\/jats:bold>\u2014The skunk was administered isotonic fluids SC daily and later every other day because of the handling-related stress. Because of the skunk's deteriorating condition, it was euthanized after 24 days of supportive care. Aleutian disease was diagnosed on the basis of positive results of a PCR assay that targeted the DNA from Aleutian disease virus (ADV); positive results for ADV were also obtained by use of plasma counterimmunoelectrophoresis and an ELISA. Genetic sequencing of the 365-base pair PCR product revealed 90% sequence identity with mink ADV.<\/jats:p>\n<jats:p><jats:bold>Clinical Relevance<\/jats:bold>\u2014In the skunk of this report, infection with a skunk-specific parvovirus resulted in clinical signs and pathologic changes similar to those associated with ADV infection in mink. For skunks with signs of renal failure, differential diagnoses should include parvovirus infection. In confirmed cases of infection with this ADV-like virus, appropriate quarantine and biosecurity measures should be in place to prevent spread to other susceptible animals within a zoological collection.<\/jats:p>","DOI":"10.2460\/javma.232.5.742","type":"journal-article","created":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T20:27:32Z","timestamp":1204403252000},"page":"742-746","source":"Crossref","is-referenced-by-count":23,"title":["Infection with Aleutian disease virus-like virus in a captive striped skunk"],"prefix":"10.2460","volume":"232","author":[{"given":"Matthew C.","family":"Allender","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juergen","family":"Schumacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy V.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie L.","family":"McCain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward C.","family":"Ramsay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan W.","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabel G.","family":"Wise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger K.","family":"Maes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Reel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Zoo and wild animal medicine","first-page":"501","article-title":"Mustelidae","author":"Fernandez-Moran","year":"2003"},{"key":"ref2","series-title":"Arch Virol","first-page":"1329","article-title":"Identification of a DNA segment in ferret Aleutian disease virus similar to a hypervariable capsid region of mink Aleutian disease parvovirus","volume":"141","author":"Saiffudin","year":"1996"},{"key":"ref3","series-title":"J Mol Biol","first-page":"403","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990"},{"key":"ref4","series-title":"J Rheumatol","first-page":"74","article-title":"Aleutian disease in mink: virology, immunology and pathogenesis","volume":"1","author":"Ingram","year":"1974"},{"key":"ref5","series-title":"Vet Rec","first-page":"232","article-title":"Suspected Aleutian disease in a wild otter (Lutra lutra)","volume":"125","author":"Wells","year":"1989"},{"key":"ref6","series-title":"Vet Rec","first-page":"479","article-title":"Aleutian disease in domestic ferrets: diagnostic findings and survey results","volume":"132","author":"Welchman","year":"1993"},{"key":"ref7","series-title":"J Am Vet Med Assoc","first-page":"1089","article-title":"Pathologic findings in rabies-sus-pect, random-source, and accidentally killed skunks","volume":"189","author":"Woolf","year":"1986"},{"key":"ref8","series-title":"Am J Vet Res","first-page":"1011","article-title":"Protides of the Mustelidae: immunoresponse of mustelids to Aleutian mink disease virus","volume":"39","author":"Kenyon","year":"1978"},{"key":"ref9","series-title":"J Wildl Dis","first-page":"394","article-title":"Antibodies to Aleutian mink disease parvovirus in free-ranging mink (Mustela lutreola) and other small carnivores from southwestern France","volume":"40","author":"Fournier-Chambrillon","year":"2004"},{"key":"ref10","series-title":"CRC handbook of parvoviruses","first-page":"87","article-title":"Mink parvoviruses","author":"Porter","year":"1990"},{"key":"ref11","series-title":"Vet Pathol","first-page":"216","article-title":"Acute interstitial pneumonia in mink kits inoculated with defined isolates of Aleutian mink disease parvovirus","volume":"31","author":"Alexandersen","year":"1994"},{"key":"ref12","series-title":"J Wildl Dis","first-page":"594","article-title":"Parvovirus infections in wild carnivores","volume":"37","author":"Steinel","year":"2001"},{"key":"ref13","series-title":"Vet Rec","first-page":"100","article-title":"Aleutian disease in laboratory ferrets","volume":"134","author":"Wolfensohn","year":"1994"},{"key":"ref14","series-title":"J Vet Diagn Invest","first-page":"594","article-title":"Persistent viral shedding during asymptomatic Aleutian mink disease parvoviral infection in a ferret","volume":"17","author":"Pennick","year":"2005"},{"key":"ref15","series-title":"Am J Vet Res","first-page":"1066","article-title":"Experimental transmission of Aleutian disease with urine","volume":"24","author":"Kenyon","year":"1963"},{"key":"ref16","series-title":"J Infect Dis","first-page":"341","article-title":"The experimental transmission of a virus causing hypergammaglobulinemia in mink: sources and modes of infection","volume":"114","author":"Gorham","year":"1964"},{"key":"ref17","series-title":"Am J Vet Res","first-page":"781","article-title":"Urinary proteins in mink with Aleutian disease","volume":"26","author":"Kenyon","year":"1965"},{"key":"ref18","series-title":"J Infect Dis","first-page":"35","article-title":"Epizootiologic studies of Aleutian disease. I. Transplacental transmission of the virus","volume":"117","author":"Padgett","year":"1967"},{"key":"ref19","series-title":"J Virol","first-page":"852","article-title":"The relationship between capsid protein (VP2) sequence and pathogenicity of Aleutian mink disease parvovirus (ADV): a possible role for raccoons in the transmission of ADV infections","volume":"70","author":"Oie","year":"1996"},{"key":"ref20","series-title":"J Pineal Res","first-page":"214","article-title":"Melatonin reduces mortality from Aleutian disease in mink (Mustela vison)","volume":"21","author":"Ellis","year":"1996"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/232\/5\/javma.232.5.742.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/232\/5\/javma.232.5.742.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/232\/5\/javma.232.5.742.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T13:30:22Z","timestamp":1741354222000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/232\/5\/javma.232.5.742.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,1]]},"references-count":20,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.2460\/javma.232.5.742","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3,1]]}}}