{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T10:57:12Z","timestamp":1793444232389,"version":"4.5.0"},"reference-count":10,"publisher":"American Veterinary Medical Association (AVMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2008,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Case Description<\/jats:bold>\u2014An 8-year-old spayed female domestic shorthair cat was evaluated for azotemia and a suspected mass in the urinary bladder 6 weeks after receiving a renal transplant. Ultrasonography revealed a mass at the ureteroneocystostomy site, and the mass was excised. Both the donor and recipient cats were seronegative for <jats:italic>Toxoplasma gondii<\/jats:italic>\u2013specific IgG antibodies prior to transplantation.<\/jats:p>\n<jats:p><jats:bold>Clinical Findings<\/jats:bold>\u2014Histologic evaluation of the mass revealed lesions indicative of extensive necrotizing pyogranulomatous cystitis with numerous intralesional <jats:italic>T gondii<\/jats:italic> tachyzoites and bradyzoite cysts.<\/jats:p>\n<jats:p><jats:bold>Treatment and Outcome<\/jats:bold>\u2014Treatment with clindamycin was initiated; however, the cat's clinical condition continued to decline, and it was euthanized 9 days after the mass was excised. Necropsy revealed <jats:italic>T gondii<\/jats:italic> cysts within the renal allograft and the transplanted ureter, with no evidence of systemic spread of organisms.<\/jats:p>\n<jats:p><jats:bold>Clinical Relevance<\/jats:bold>\u2014Toxoplasmosis should be considered as a differential diagnosis for azotemia in feline renal transplant recipients regardless of the results of assays for <jats:italic>T gondii<\/jats:italic> antibodies in the serum of donors or recipients. This report illustrated the need for improved screening of donor and recipient cats and the importance of minimizing exposure to potential sources of <jats:italic>T gondii<\/jats:italic> after transplantation.<\/jats:p>","DOI":"10.2460\/javma.232.7.1010","type":"journal-article","created":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T14:57:40Z","timestamp":1207061860000},"page":"1010-1012","source":"Crossref","is-referenced-by-count":18,"title":["Pyogranulomatous cystitis associated with Toxoplasma gondii infection in a cat after renal transplantation"],"prefix":"10.2460","volume":"232","author":[{"given":"Barbro C.","family":"Nordquist","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillian R.","family":"Aronson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"J Am Vet Med Assoc","first-page":"1593","article-title":"Toxoplasmosis","volume":"205","author":"Dubey","year":"1994"},{"key":"ref2","series-title":"N Engl J Med","first-page":"1741","article-title":"Infection in organ-transplant recipients","volume":"338","author":"Fishman","year":"1998"},{"key":"ref3","series-title":"J Postgrad Med","first-page":"146","article-title":"Transfusion-transmitted infections: existing and emerging pathogens","volume":"51","author":"Kaur","year":"2005"},{"key":"ref4","series-title":"Semin Vet Med Surg (Small Anim)","first-page":"154","article-title":"Feline toxoplasmosis: interpretation of diagnostic test results","volume":"11","author":"Lappin","year":"1996"},{"key":"ref5","series-title":"Am J Vet Res","first-page":"874","article-title":"Seroprevalence of Toxoplasma gondii antibodies in clinically ill cats in the United States","volume":"66","author":"Vollaire","year":"2005"},{"key":"ref6","series-title":"Vet Pathol","first-page":"350","article-title":"Immunity to feline toxoplasmosis: modification by administration of corticosteroids","volume":"11","author":"Dubey","year":"1974"},{"key":"ref7","series-title":"Parasitol Today","first-page":"150","article-title":"Some opportunistic parasitic infections in AIDS: candidiasis, pneumocystosis, cryptosporidiosis, toxoplasmosis","volume":"14","author":"Kasper","year":"1998"},{"key":"ref8","series-title":"Clin Infect Dis","first-page":"1005","article-title":"Parasitic central nervous system infections in immunocompromised hosts","volume":"40","author":"Walker","year":"2005"},{"key":"ref9","series-title":"Am J Pathol","first-page":"1486","article-title":"Feline immunodeficiency virus predisposes cats to acute generalized toxoplasmosis","volume":"143","author":"Davidson","year":"1993"},{"key":"ref10","series-title":"J Am Vet Med Assoc","first-page":"1123","article-title":"Acute toxoplasmosis following renal transplantation in three cats and a dog","volume":"215","author":"Bernsteen","year":"1999"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/232\/7\/javma.232.7.1010.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/232\/7\/javma.232.7.1010.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/232\/7\/javma.232.7.1010.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T13:29:17Z","timestamp":1741354157000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/232\/7\/javma.232.7.1010.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,1]]},"references-count":10,"journal-issue":{"issue":"7"},"URL":"https:\/\/doi.org\/10.2460\/javma.232.7.1010","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2008,4,1]]}}}