{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:54:31Z","timestamp":1787025271399,"version":"build-2736575974"},"reference-count":60,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2008,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    \u2014To provide long-term follow-up information for a series of dogs and cats with invasive and noninvasive thymomas treated by excision alone.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design<\/jats:bold>\n                    \u2014Retrospective case series.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Animals<\/jats:bold>\n                    \u20149 cats and 11 dogs with thymoma.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Procedures<\/jats:bold>\n                    \u2014Medical records were reviewed. The following factors were analyzed for their effect on prognosis: age of dog or cat, invasiveness of the tumor, percentage of lymphocytes in the mass (percentage lymphocyte composition) on histologic evaluation, and mitotic index of the mass.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    \u2014All patients were treated with excision of the tumor alone. Median overall survival time for the cats was 1,825 days, with a 1-year survival rate of 89% and a 3-year survival rate of 74%. Median overall survival time for the dogs was 790 days, with a 1-year survival rate of 64% and a 3-year survival rate of 42%. Recurrence of thymoma was observed in 2 cats and 1 dog, and a second surgery was performed in each, with subsequent survival times of 5, 3, and 4 years following the first surgery. Percentage lymphocyte composition of the mass was the only factor that was significantly correlated with survival time; animals with a high percentage of lymphocytes lived longer.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\n                    \u2014Results of this study indicated that most cats and dogs with thymomas did well after excision. Even cats and dogs with invasive masses that survived the surgery and the few cats and dogs with recurrent thymomas or paraneoplastic syndromes had a good long-term outcome. Excision should be considered an effective treatment option for dogs and cats with thymomas.\n                  <\/jats:p>","DOI":"10.2460\/javma.232.8.1186","type":"journal-article","created":{"date-parts":[[2008,4,15]],"date-time":"2008-04-15T10:14:53Z","timestamp":1208254493000},"page":"1186-1192","source":"Crossref","is-referenced-by-count":96,"title":["Results of excision of thymoma in cats and dogs: 20 cases (1984\u20132005)"],"prefix":"10.2460","volume":"232","author":[{"given":"Julia C.","family":"Zitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Birchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo C.","family":"Couto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie F.","family":"Samii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven E.","family":"Weisbrode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory S.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"J Small Anim Pract","first-page":"393","article-title":"Review of thymic pathology in 30 cats and 36 dogs","volume":"38","author":"Day","year":"1997"},{"key":"ref2","series-title":"Tumors in domestic animals","first-page":"231","article-title":"Tumors of the lymphoid and hematopoietic tissues: thymoma","author":"Moulton","year":"1990"},{"key":"ref3","series-title":"Small animal clinical oncology","first-page":"530","article-title":"Miscellaneous tumors: thymoma","author":"Withrow","year":"1996"},{"key":"ref4","series-title":"Managing the veterinary cancer patient: a practice manual","author":"Ogilvie","year":"1996"},{"key":"ref5","series-title":"J Am Vet Med Assoc","first-page":"1007","article-title":"Thymoma in dogs: 23 cases (1980\u20131991)","volume":"205","author":"Atwater","year":"1994"},{"key":"ref6","series-title":"Medicine (Baltimore)","first-page":"411","article-title":"Myasthenia gravis in patients with thymoma, with particular reference to onset after thymectomy","volume":"57","author":"Namba","year":"1978"},{"key":"ref7","series-title":"Can Vet J","first-page":"497","article-title":"A comparison between the cytological and histological characteristics in thirteen canine and feline thymomas","volume":"30","author":"Rae","year":"1989"},{"key":"ref8","series-title":"Diagnostic cytology of the dog and cat","first-page":"181","article-title":"The lung parenchyma","author":"Cowell","year":"1999"},{"key":"ref9","series-title":"Small animal clinical oncology","first-page":"797","article-title":"Molecular\/targeted therapy of cancer","author":"Withrow","year":"2007"},{"key":"ref10","series-title":"J Neurol Sci","first-page":"23","article-title":"Hepatic metastatic thymoma and myasthenia gravis twenty-two years after the apparent cure of an invasive thymoma. A case report and review of the literature","volume":"76","author":"Denayer","year":"1986"},{"key":"ref11","series-title":"Cancer","first-page":"1752","article-title":"Treatment of invasive or metastatic thymoma: report of eleven cases","volume":"47","author":"Chahinian","year":"1981"},{"key":"ref12","series-title":"Cancer","first-page":"2485","article-title":"Follow-up study of thymomas with special reference to their clinical stages","volume":"48","author":"Masaoka","year":"1981"},{"key":"ref13","series-title":"Vet Radiol Ultrasound","first-page":"542","article-title":"Computed tomographic evaluation of canine and feline mediastinal masses in 14 patients","volume":"45","author":"Yoon","year":"2004"},{"key":"ref14","series-title":"J Comp Pathol","first-page":"187","article-title":"Primary tumours of the thymus in the rat","volume":"99","author":"Naylor","year":"1988"},{"key":"ref15","series-title":"Am J Clin Pathol","first-page":"168","article-title":"Fine-needle aspiration biopsy of the mediastinum. A multi-institutional analysis","volume":"105","author":"Powers","year":"1996"},{"key":"ref16","series-title":"Vet Clin North Am Small Anim Pract","first-page":"755","article-title":"Canine thymomas","volume":"15","author":"Aronsohn","year":"1985"},{"key":"ref17","series-title":"Semin Diagn Pathol","first-page":"250","article-title":"Thymomas and thymic carcinomas","volume":"7","author":"Walker","year":"1990"},{"key":"ref18","series-title":"Diseases of the cat: medicine & surgery","article-title":"Tumors and tumorlike lesions","author":"Carpenter","year":"1987"},{"key":"ref19","series-title":"AJR Am J Roentgenol","first-page":"515","article-title":"Mediastinal imaging in myasthenia gravis: correlation of chest radiography, CT, MR, and surgical findings","volume":"148","author":"Batra","year":"1987"},{"key":"ref20","series-title":"AJR Am J Roentgenol","first-page":"1171","article-title":"Masses of the anterior mediastinum: CT and MR imaging","volume":"157","author":"Brown","year":"1991"},{"key":"ref21","series-title":"Can Vet J","first-page":"593","article-title":"Veterinary diagnostic imaging. Thymoma","volume":"47","author":"Hylands","year":"2006"},{"key":"ref22","series-title":"Acta Radiol","first-page":"380","article-title":"Thymic lesions and myasthenia gravis; diagnosis based on mediastinal imaging and pathological findings","volume":"43","author":"Pirronti","year":"2002"},{"key":"ref23","series-title":"Acta Radiol","first-page":"262","article-title":"Differential diagnosis between thymoma and non-thymoma by dynamic MR imaging","volume":"43","author":"Sakai","year":"2002"},{"key":"ref24","series-title":"Textbook of small animal surgery","article-title":"The thymus","author":"Bellah","year":"2003"},{"key":"ref25","series-title":"Ann Thorac Surg","first-page":"46","article-title":"Myasthenia gravis with thymoma: analysis of and postoperative prognosis for 65 patients with thymomatous myasthenia gravis","volume":"38","author":"Monden","year":"1984"},{"key":"ref26","series-title":"Ann Thorac Surg","first-page":"165","article-title":"Recurrence of thymoma: clinicopathological features, therapy, and prognosis","volume":"39","author":"Monden","year":"1985"},{"key":"ref27","series-title":"Compend Contin Educ Pract Vet","first-page":"24","article-title":"The thymus as part of the endocrine system","volume":"8","author":"Monroe","year":"1986"},{"key":"ref28","series-title":"Textbook of small animal surgery: the thymus","first-page":"1089","author":"Bellah","year":"2003"},{"key":"ref29","series-title":"J Am Vet Med Assoc","first-page":"1782","article-title":"Surgical treatment of thymoma in cats: 12 cases (1987\u20131992)","volume":"204","author":"Gores","year":"1994"},{"key":"ref30","series-title":"Vet Immunol Immunopathol","first-page":"97","article-title":"Titin and ryanodine receptor autoantibodies in dogs with thymoma and late-onset myasthenia gravis","volume":"78","author":"Shelton","year":"2001"},{"key":"ref31","series-title":"J Am Anim Hosp Assoc","first-page":"111","article-title":"Focal myasthenia gravis as a paraneoplastic syndrome of canine thymoma: improvement following thymectomy","volume":"32","author":"Lainesse","year":"1996"},{"key":"ref32","series-title":"Aust Vet J","first-page":"543","article-title":"Acquired myasthenia gravis associated with a non-invasive thymic carcinoma in a dog","volume":"81","author":"Stenner","year":"2003"},{"key":"ref33","series-title":"J Vet Med Sci","first-page":"637","article-title":"Thymoma and multiple cysts in a dog with acquired myasthenia gravis","volume":"64","author":"Uchida","year":"2002"},{"key":"ref34","series-title":"J Small Anim Pract","first-page":"376","article-title":"Treatment of acquired myasthenia gravis associated with thymoma in two dogs","volume":"37","author":"Rusbridge","year":"1996"},{"key":"ref35","series-title":"J Am Vet Med Assoc","first-page":"1173","article-title":"Third degree atrioventricular block and acquired myasthenia gravis in four dogs","volume":"206","author":"Hackett","year":"1995"},{"key":"ref36","series-title":"Vet Dermatol","first-page":"279","article-title":"Invited review: cutaneous paraneoplastic syndromes in dogs and cats: a review of the literature","volume":"14","author":"Turek","year":"2003"},{"key":"ref37","series-title":"Vet Pathol","first-page":"429","article-title":"Thymoma-associated exfoliative dermatitis in cats","volume":"41","author":"Rottenberg","year":"2004"},{"key":"ref38","series-title":"Feline Pract","first-page":"8","article-title":"Exfoliative dermatitis in association with thymoma in three cats","author":"Scott","year":"1995"},{"key":"ref39","series-title":"J Am Vet Med Assoc","first-page":"1628","article-title":"Excision of a locally invasive thymoma causing cranial vena caval syndrome in a dog","volume":"210","author":"Hunt","year":"1997"},{"key":"ref40","series-title":"J Am Vet Med Assoc","first-page":"1205","article-title":"Use of a jugular vein autograft for reconstruction of the cranial vena cava in a dog with invasive thymoma and cranial vena cava syndrome","volume":"225","author":"Holsworth","year":"2004"},{"key":"ref41","series-title":"J Am Vet Med Assoc","first-page":"1355","article-title":"Clinical and pathologic features of thymoma in 15 dogs","volume":"184","author":"Aronsohn","year":"1984"},{"key":"ref42","series-title":"J Am Anim Hosp Assoc","first-page":"347","article-title":"Surgical treatment of a thymoma in a cat","volume":"22","author":"Martin","year":"1986"},{"key":"ref43","series-title":"Can Vet J","first-page":"280","article-title":"Malignant thymoma with widespread metastases in a dog: case report and brief literature review","volume":"25","author":"Mitcham","year":"1984"},{"key":"ref44","series-title":"J Small Anim Pract","first-page":"167","article-title":"The cytopathological features of thymoma in a dog","volume":"26","author":"Mills","year":"1985"},{"key":"ref45","series-title":"J Am Anim Hosp Assoc","first-page":"281","article-title":"Hypercalcemia in a dog with thymoma","volume":"27","author":"Harris","year":"1991"},{"key":"ref46","series-title":"J Am Anim Hosp Assoc","first-page":"63","article-title":"Thymoma and acquired myasthenia gravis in the dog: a case report and review of 13 additional cases","volume":"28","author":"Klebanow","year":"1992"},{"key":"ref47","series-title":"J Am Vet Med Assoc","first-page":"1187","article-title":"Radiation treatment for thymoma in a dog","volume":"190","author":"Hitt","year":"1987"},{"key":"ref48","series-title":"J Am Vet Med Assoc","first-page":"1291","article-title":"Acquired myasthenia gravis in a cat with thymoma","volume":"196","author":"Scott-Moncrieff","year":"1990"},{"key":"ref49","series-title":"J Pathol","first-page":"177","article-title":"Thymoma with myasthenia gravis in a dog","volume":"108","author":"Hall","year":"1972"},{"key":"ref50","series-title":"Vet Rec","first-page":"392","article-title":"Myasthenia gravis, thymoma and myositis in a dog","volume":"97","author":"Darke","year":"1975"},{"key":"ref51","series-title":"Neurology","article-title":"Myasthenia gravis with thymoma","author":"Lovelace","year":"1997"},{"key":"ref52","series-title":"J Small Anim Pract","first-page":"89","article-title":"Invasive thymoma complicated by pneumothorax and haemothorax in a dog","volume":"27","author":"Squires","year":"1986"},{"key":"ref53","series-title":"J Small Anim Pract","first-page":"564","article-title":"Hypercalcemia in the dog: a study of 40 cases","volume":"32","author":"Elliott","year":"1991"},{"key":"ref54","series-title":"Can Vet J","first-page":"867","article-title":"Serum parathyroid hormonerelated protein concentration in a dog with a thymoma and persistent hypercalcemia","volume":"41","author":"Foley","year":"2000"},{"key":"ref55","series-title":"J Am Vet Med Assoc","first-page":"306","article-title":"Thymoma in the dog: two case reports and review of 20 additional cases","volume":"183","author":"Bellah","year":"1983"},{"key":"ref56","series-title":"Cancer","first-page":"1871","article-title":"Nonsurgical management of malignant thymoma","volume":"85","author":"Hejna","year":"1999"},{"key":"ref57","series-title":"J Am Anim Hosp Assoc","first-page":"489","article-title":"Radiation therapy in the treatment of canine and feline thymomas: a retrospective study (1985\u20131999)","volume":"37","author":"Smith","year":"2001"},{"key":"ref58","series-title":"J Am Anim Hosp Assoc","first-page":"483","article-title":"Radiotherapy in three suspect cases of feline thymoma","volume":"37","author":"Kaser-Hotz","year":"2001"},{"key":"ref59","series-title":"Clin Oncol (R Coll Radiol)","first-page":"64","article-title":"Dramatic response of recurrent invasive thymoma to high dose corticosteroids","volume":"4","author":"Kirkove","year":"1992"},{"key":"ref60","series-title":"Cancer Treat Rep","first-page":"1397","article-title":"Invasive thymoma responsive to oral corticosteroids","volume":"62","author":"Shellito","year":"1978"}],"container-title":["Journal of the American Veterinary Medical 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