{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T22:42:13Z","timestamp":1793486533477,"version":"4.5.0"},"reference-count":33,"publisher":"American Veterinary Medical Association (AVMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2008,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Case Description<\/jats:bold>\u2014A 6-year-old German Shorthaired Pointer was evaluated for possible reconstruction of a mandibular defect resulting from gunshot trauma.<\/jats:p>\n<jats:p><jats:bold>Clinical Findings<\/jats:bold>\u2014A 5-cm defect of the right mandibular body was evident. A segment of the mandibular body was removed 9 weeks earlier because of severe contamination and comminution associated with gunshot trauma. Subsequent right-sided mandibular drift resulted in malocclusion in which the left mandibular canine tooth caused trauma to mucosa of the hard palate medial to the left maxillary canine tooth. The right maxillary canine tooth caused trauma to gingiva lingual to the right mandibular canine tooth.<\/jats:p>\n<jats:p><jats:bold>Treatment and Outcome<\/jats:bold>\u2014The right mandible was stabilized with a 2.0-mm maxillofacial miniplate positioned along the lateral alveolar margin and a 2.4-mm locking mandibular reconstruction plate placed along the ventrolateral mandible. An absorbable compressionresistant matrix containing collagen, hydroxyapatite, and tricalcium phosphate was soaked in recombinant human bone morphogenetic protein-2 (rhBMP-2; 7.2 mL of a 0.5 mg\/mL solution for a dose of 3.6 mg) and placed in the defect. By 4 weeks after surgery, an exuberant callus was evident at the site of the defect. By 7 months after surgery, the callus had remodeled, resulting in normal appearance, normal occlusion, and excellent function of the jaw.<\/jats:p>\n<jats:p><jats:bold>Clinical Relevance<\/jats:bold>\u2014Mandibular defects resulting from gunshot trauma can be treated by removal of contaminated tissue and comminuted bone fragments, followed by staged reconstruction. The combination of rhBMP-2 and compression-resistant matrix was effective in a staged mandibular reconstruction in a dog with a severe traumatic mandibular defect.<\/jats:p>","DOI":"10.2460\/javma.233.10.1598","type":"journal-article","created":{"date-parts":[[2008,11,17]],"date-time":"2008-11-17T13:37:48Z","timestamp":1226929068000},"page":"1598-1604","source":"Crossref","is-referenced-by-count":25,"title":["Mandibular reconstruction after gunshot trauma in a dog by use of recombinant human bone morphogenetic protein-2"],"prefix":"10.2460","volume":"233","author":[{"given":"John R.","family":"Lewis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy J.","family":"Boudrieau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander M.","family":"Reiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard J.","family":"Seeherman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Gilley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"AO principles of fracture management in the dog and cat","first-page":"98","article-title":"Fractures of the mandible","author":"Boudrieau","year":"2005"},{"key":"ref2","series-title":"Laryngoscope","first-page":"1481","article-title":"Mandibular reconstruction using bone morphogenetic protein 2: long-term follow-up in a canine model","volume":"109","author":"Toriumi","year":"1999"},{"key":"ref3","series-title":"J Otolaryngol","first-page":"407","article-title":"Effect of recombinant human bone morphogenetic protein 7 on bone density during distraction osteogenesis of the rabbit mandible","volume":"34","author":"Zakhary","year":"2005"},{"key":"ref4","series-title":"Arch Facial Plast Surg","first-page":"103","article-title":"Defect repair in the rat mandible with bone morphogenic proteins and marrow cells","volume":"5","author":"Arosarena","year":"2003"},{"key":"ref5","series-title":"Int J Oral Maxillofac Surg","first-page":"528","article-title":"Acceleration of callus maturation using rhOP-1 in mandibular distraction osteogenesis in a rat model","volume":"32","author":"Terheyden","year":"2003"},{"key":"ref6","series-title":"Bone","article-title":"Animal studies of application of rhBMP-2 in maxillofacial reconstruction","author":"Boyne","year":"1996"},{"key":"ref7","series-title":"J Bone Joint Surg Am","article-title":"Application of bone morphogenetic proteins in the treatment of clinical oral and maxillofacial osseous defects","author":"Boyne","year":"2001"},{"key":"ref8","series-title":"ANZ J Surg","first-page":"626","article-title":"Bone morphogenetic proteins in clinical applications","volume":"77","author":"Gautschi","year":"2007"},{"key":"ref9","series-title":"Int J Oral Maxillofac Surg","first-page":"287","article-title":"Mechanical evaluation of mandibular defects reconstructed using osteogenic protein-1 (rhOP-1) in a sheep model: a critical analysis","volume":"34","author":"Abu-Serriah","year":"2005"},{"key":"ref10","series-title":"Int J Oral Maxillofac Surg","first-page":"461","article-title":"Mandibular reconstruction in miniature pigs with prefabricated vascularized bone grafts using recombinant human osteogenic protein-1: a preliminary study","volume":"28","author":"Terheyden","year":"1999"},{"key":"ref11","series-title":"Int J Oral Maxillofac Surg","first-page":"373","article-title":"Mandibular reconstruction with a prefabricated vascularized bone graft using recombinant human osteogenic protein-1: an experimental study in miniature pigs. 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