{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:43:10Z","timestamp":1788280990259,"version":"build-2803163510"},"reference-count":21,"publisher":"American Veterinary Medical Association (AVMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2008,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Case Description<\/jats:bold>\u2014Acute severe systemic reactions developed during IV administration of an ionic iodinated contrast agent (iothalamate meglumine) in 2 dogs undergoing contrast-enhanced computed tomography.<\/jats:p>\n<jats:p><jats:bold>Clinical Findings<\/jats:bold>\u2014Both dogs developed marked changes in heart rate and systolic arterial blood pressure during or immediately after IV administration of the contrast agent. The first dog became profoundly hypertensive and bradycardic with poor oxygenation, apparent bronchospasm, and prolonged diarrhea. The second dog became hypotensive and tachycardic with erythema on the ventral aspect of the abdomen and pelvic limbs, periocular edema, and diarrhea.<\/jats:p>\n<jats:p><jats:bold>Treatment and Outcome<\/jats:bold>\u2014Both dogs were treated for shock by means of IV fluid administration, and anesthesia was discontinued. The first dog was placed on a ventilator to improve oxygenation but was hypertensive and unresponsive for 6.5 hours following contrast agent administration. Bloody diarrhea persisted once consciousness was regained. The dog was discharged 3 days after contrast agent administration, and diarrhea resolved 15 days later. The second dog responded to phenylephrine administration, but urine output appeared low immediately following recovery from anesthesia. Urine output was normal the following day, and the dog was released 36 hours after contrast administration with no residual adverse effects.<\/jats:p>\n<jats:p><jats:bold>Clinical Relevance<\/jats:bold>\u2014Findings highlighted the potential risk for severe reactions associated with IV administration of ionic iodinated contrast agents in dogs. Both hypertensive and hypotensive responses were seen. Supportive care for systemic manifestations was effective in these 2 dogs, and extended hospitalization was not necessary.<\/jats:p>","DOI":"10.2460\/javma.233.2.274","type":"journal-article","created":{"date-parts":[[2008,7,15]],"date-time":"2008-07-15T15:16:19Z","timestamp":1216134979000},"page":"274-278","source":"Crossref","is-referenced-by-count":33,"title":["Severe reaction to intravenous administration of an ionic iodinated contrast agent in two anesthetized dogs"],"prefix":"10.2460","volume":"233","author":[{"given":"Rachel E.","family":"Pollard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Pascoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Curr Pharm Des","first-page":"3359","article-title":"Hypersensitivity reactions to iodinated contrast media","volume":"12","author":"Gueant-Rodriguez","year":"2006"},{"key":"ref2","series-title":"Br J Radiol","first-page":"368","article-title":"Acute adverse reactions to magnetic resonance contrast media\u2014gadolinium chelates","volume":"79","author":"Li","year":"2006"},{"key":"ref3","series-title":"Eur Radiol","first-page":"1267","article-title":"Adverse reactions to iodinated contrast media","volume":"11","author":"Morcos","year":"2001"},{"key":"ref4","series-title":"Lancet","first-page":"466","article-title":"Incidence and severity of anaphylactoid reactions to colloid volume substitutes","volume":"1","author":"Ring","year":"1977"},{"issue":"suppl 1","key":"ref5","series-title":"Invest Radiol","first-page":"S37","article-title":"The etiology of contrast medium reactions","volume":"29","author":"Almen","year":"1994"},{"key":"ref6","series-title":"Radiology","first-page":"621","article-title":"Adverse reactions to ionic and nonionic contrast media. A report from the Japanese Committee on the Safety of Contrast Media","volume":"175","author":"Katayama","year":"1990"},{"key":"ref7","series-title":"Drug Saf","first-page":"313","article-title":"Jr. Adverse effects of contrast media: incidence, prevention and management","volume":"19","author":"Thomsen","year":"1998"},{"key":"ref8","series-title":"AJR Am J Roentgenol","first-page":"939","article-title":"A prospective trial of ionic vs nonionic contrast agents in routine clinical practice: comparison of adverse effects","volume":"152","author":"Wolf","year":"1989"},{"key":"ref9","series-title":"Am J Vet Res","article-title":"Hemodynamic and serum biochemical alterations associated with 3 types of intravenous contrast media administration in anesthetized dogs","volume":"69","author":"Pollard","year":"2008"},{"key":"ref10","series-title":"Diagnosis and treatment of adverse reactions to radiopaque contrast agents","author":"Walter","year":"1986"},{"key":"ref11","series-title":"Am J Cardiol","first-page":"2E","article-title":"Cardiovascular effects of contrast agents","volume":"64","author":"Dawson","year":"1989"},{"key":"ref12","series-title":"Br J Radiol","first-page":"647","article-title":"The release of histamine from human basophils by radiological contrast agents","volume":"56","author":"Assem","year":"1983"},{"key":"ref13","series-title":"Br J Radiol","first-page":"653","article-title":"Contrast media and enzyme inhibition. I. Cholinesterase","volume":"56","author":"Dawson","year":"1983"},{"key":"ref14","series-title":"J Am Vet Med Assoc","first-page":"899","article-title":"Acute renal failure associated with contrast medium administration in a dog","volume":"199","author":"Ihle","year":"1991"},{"key":"ref15","series-title":"J Am Soc Nephrol","first-page":"177","article-title":"Contrast nephropathy","volume":"11","author":"Murphy","year":"2000"},{"key":"ref16","series-title":"Br J Radiol","first-page":"357","article-title":"Contrast media-induced nephrotoxicity\u2014questions and answers","volume":"71","author":"Morcos","year":"1998"},{"issue":"suppl 1","key":"ref17","series-title":"BJU Int","first-page":"1","article-title":"Radiographic contrast media","volume":"86","author":"Thomsen","year":"2000"},{"key":"ref18","series-title":"JAMA","first-page":"2324","article-title":"Thyroid storm after cardiac angiography with iodinated contrast medium. Occurrence in a patient with a previously euthyroid autonomous nodule of the thyroid","volume":"235","author":"Blum","year":"1976"},{"key":"ref19","series-title":"J Emerg Med","first-page":"23","article-title":"Cardiovascular manifestations of thyroid storm: a case report","volume":"25","author":"Wald","year":"2003"},{"key":"ref20","series-title":"AJR Am J Roentgenol","first-page":"43","article-title":"Plasma catecholamines in pheochromocytoma: effect of urographic contrast media","volume":"143","author":"Raisanen","year":"1984"},{"key":"ref21","series-title":"J Vet Intern Med","first-page":"272","article-title":"Pheochromocytoma in dogs: 61 cases (1984\u20131995)","volume":"11","author":"Barthez","year":"1997"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/233\/2\/javma.233.2.274.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/233\/2\/javma.233.2.274.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/233\/2\/javma.233.2.274.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T13:26:09Z","timestamp":1741353969000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/233\/2\/javma.233.2.274.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,15]]},"references-count":21,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.2460\/javma.233.2.274","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2008,7,15]]}}}