{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:01:54Z","timestamp":1783728114692,"version":"3.55.0"},"reference-count":28,"publisher":"American Veterinary Medical Association (AVMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2008,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To evaluate the efficacy and safety of administration of cefovecin, compared with cefadroxil, for treatment of naturally occurring secondary superficial pyoderma, abscesses, and infected wounds in dogs.<\/jats:p>\n<jats:p><jats:bold>Design<\/jats:bold>\u2014Multicenter, randomized, positive-controlled clinical trial.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u2014235 client-owned dogs.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Dogs with clinical signs of skin infection confirmed via bacteriologic culture were randomly allocated to receive a single SC injection of cefovecin (8 mg\/kg [3.6 mg\/lb]) followed by placebo administered PO twice daily for 14 days or cefadroxil (22 mg\/kg [10 mg\/lb]) administered PO twice daily for 14 days following a placebo injection. Two 14-day treatment courses were permitted. Treatment success was defined as reduction of clinical signs to mild or absent at the final assessment.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014Clinical efficacy achieved with cefovecin in dogs was equivalent to that observed with cefadroxil. At the final assessment, 14 days following the completion of treatment (on day 28 or 42), 92.4% (109\/118) of the cefovecin group and 92.3% (108\/117) of the cefadroxil group were treatment successes. There were no serious adverse events or deaths related to treatment.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014A single cefovecin injection (8 mg\/kg) administered SC, which could be repeated once after 14 days, was safe and effective against naturally occurring skin infections in dogs and as effective as cefadroxil administered PO twice daily for 14 or 28 days.<\/jats:p>","DOI":"10.2460\/javma.233.3.433","type":"journal-article","created":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T12:13:33Z","timestamp":1217592813000},"page":"433-439","source":"Crossref","is-referenced-by-count":22,"title":["Efficacy and safety of cefovecin in treating bacterial folliculitis, abscesses, or infected wounds in dogs"],"prefix":"10.2460","volume":"233","author":[{"given":"Robert","family":"Six","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"Cherni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Chesebrough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn","family":"Cleaver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy J.","family":"Lindeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Papp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry L.","family":"Skogerboe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Weigel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph F.","family":"Boucher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Stegemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Muller and Kirk's small animal dermatology","first-page":"274","article-title":"Bacterial skin diseases","author":"Scott","year":"2001"},{"key":"ref2","series-title":"Small animal clinical pharmacology and therapeutics","article-title":"Treatment of bacterial infections","author":"Boothe","year":"2001"},{"key":"ref3","series-title":"Vet Dermatol","first-page":"75","article-title":"The distribution of Staphylococcus intermedius and coagulase-negative staphylococci on the hair, skin surface, within the hair follicles and on the mucous membranes of dogs","volume":"5","author":"Harvey","year":"1994"},{"key":"ref4","series-title":"Res Vet Sci","first-page":"279","article-title":"Adherence by Staphylococcus intermedius to canine keratinocytes in atopic dermatitis","volume":"68","author":"McEwan","year":"2000"},{"key":"ref5","series-title":"Vet Dermatol","first-page":"187","article-title":"Cephalosporins\u2014pharmacological basis of clinical use in veterinary dermatology","volume":"10","author":"Mason","year":"1999"},{"key":"ref6"},{"key":"ref7"},{"key":"ref8","series-title":"J Am Vet Med Assoc","first-page":"530","article-title":"Comparison of the efficacy of cefadroxil and generic and proprietary cephalexin in the treatment of pyoderma in dogs","volume":"203","author":"Frank","year":"1993"},{"key":"ref9","series-title":"Kirk's current veterinary therapy XII","first-page":"611","article-title":"Management of the chronic and recurrent pyoderma in the dog","author":"DeBoer","year":"1995"},{"key":"ref10","series-title":"Antimicrob Agents Chemother","first-page":"2286","article-title":"Antimicrobial activity and spectrum of cefovecin, a new extended-spectrum cephalosporin, against pathogens collected from dogs and cats in Europe and North America","volume":"50","author":"Stegemann","year":"2006"},{"key":"ref11","series-title":"J Vet Pharmacol Ther","first-page":"501","article-title":"Pharmacokinetics and pharmacodynamics of cefovecin in dogs","volume":"29","author":"Stegemann","year":"2006"},{"key":"ref12","series-title":"J Small Anim Pract","first-page":"378","article-title":"Clinical efficacy and safety of cefovecin in the treatment of canine pyoderma and wound infections","volume":"48","author":"Stegemann","year":"2007"},{"key":"ref13","series-title":"Convenia (cefovecin). 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