{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:24:37Z","timestamp":1771658677209,"version":"3.50.1"},"reference-count":33,"publisher":"American Veterinary Medical Association (AVMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2008,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objectives<\/jats:bold>\u2014To evaluate the use of human albumin in critically ill dogs.<\/jats:p>\n<jats:p><jats:bold>Design<\/jats:bold>\u2014Retrospective case series.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u201473 client-owned hospitalized dogs.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Medical records of dogs that received human albumin were reviewed to assess effects of the use of human albumin on serum albumin concentration, colloid osmotic pressure, and total protein concentration; determine the relationships between these variables and outcome; and assess its safety. Data for signalment, diagnoses, physiologic variables, dosage, amount of crystalloid fluid administered prior to human albumin administration, complications, and outcome were reviewed. Additionally, pre- and postadministration values for serum albumin, colloid osmotic pressure, and total protein were recorded.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014Administration of human albumin resulted in significant changes in serum albumin, colloid osmotic pressure, and total protein. The serum albumin, total protein, degree of improvement in serum albumin, colloid osmotic pressure, and dosage of human albumin were significantly greater in survivors. Seventeen of 73 (23%) dogs had at least 1 complication that could be potentially associated with the administration of human albumin that occurred during or immediately following administration of human albumin. Three of 73 (4%) dogs had severe delayed complications.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Administration of human albumin significantly increased serum albumin, and total protein concentrations and colloid osmotic pressure, especially in survivors. Because of the high mortality rate of the study population and other confounding factors, it was uncertain whether complications were associated with the underlying disease or with human albumin administration. Acute and delayed complications may have been under-recognized.<\/jats:p>","DOI":"10.2460\/javma.233.4.607","type":"journal-article","created":{"date-parts":[[2008,8,18]],"date-time":"2008-08-18T12:20:30Z","timestamp":1219062030000},"page":"607-612","source":"Crossref","is-referenced-by-count":75,"title":["Evaluation of use of human albumin in critically ill dogs: 73 cases (2003\u20132006)"],"prefix":"10.2460","volume":"233","author":[{"given":"Amy V.","family":"Trow","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Rozanski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armelle M.","family":"deLaforcade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel L.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"J Vet Emerg Crit Care","first-page":"96","article-title":"Prognostic value of clinical nutritional assessment in canine patients","volume":"3","author":"Michel","year":"1993"},{"key":"ref2","series-title":"J Vet Emerg Crit Care","first-page":"113","article-title":"The role of albumin replacement in the critically ill veterinary patient","volume":"12","author":"Mazzaferro","year":"2002"},{"key":"ref3","series-title":"Am J Vet Res","first-page":"948","article-title":"Evaluation of the survival prediction index as a model of risk stratification for clinical research in dogs admitted to intensive care units at four locations","volume":"62","author":"King","year":"2001"},{"key":"ref4","series-title":"J Vet Emerg Crit Care","first-page":"49","article-title":"Colloid oncotic pressure and the clinical use of colloidal solutions","volume":"3","author":"Concannon","year":"1993"},{"key":"ref5","series-title":"Am J Vet Res","first-page":"910","article-title":"Comparison of measured and calculated values for colloid osmotic pressure in hospitalized animals","volume":"55","author":"Brown","year":"1994"},{"key":"ref6","series-title":"Crit Care Med","first-page":"3137","article-title":"Hypoproteinemia predicts acute respiratory distress syndrome development, weight gain, and death in patients with sepsis","volume":"28","author":"Mangialardi","year":"2000"},{"key":"ref7","series-title":"Am J Kidney Dis","first-page":"139","article-title":"Serum albumin, C-reactive protein, interleukin 6 and fetoin A as predictors of malnutrition, cardiovascular disease and mortality in patients with ESRD","volume":"47","author":"Honda","year":"2006"},{"key":"ref8","series-title":"Am J Kidney Dis","first-page":"61","article-title":"Protein malnutrition and hypoalbuminemia as predictors of vascular events and mortality in ESRD","volume":"43","author":"Cooper","year":"2004"},{"key":"ref9","series-title":"Chest","first-page":"1619","article-title":"The APACHE II prognostic system. 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