{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T09:20:56Z","timestamp":1793697656189,"version":"4.5.1"},"reference-count":26,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2008,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To compare serum triglyceride concentrations obtained after food had been withheld (ie, fasting concentrations) in dogs with epilepsy that had been treated long term (t 3 months) with phenobarbital or with phenobarbital and potassium bromide with concentrations in healthy control dogs.<\/jats:p>\n<jats:p><jats:bold>Design<\/jats:bold>\u2014Cross-sectional study.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u201457 epileptic dogs that had been treated with phenobarbital (n = 28) or with phenobarbital and bromide (29) and 57 healthy, untreated control dogs matched on the basis of age, breed, sex, neuter status, and body condition score.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Blood samples were collected after food had been withheld for at least 12 hours, and serum biochemical and lipid concentrations were determined. Oral fat tolerance tests were performed in 15 control dogs and 9 dogs with epilepsy treated with phenobarbital alone.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u201419 of the 57 (33%) epileptic dogs had fasting serum triglyceride concentrations greater than the upper reference limit. Nine (16%) dogs had a history of pancreatitis, and 5 of the 9 had high fasting serum triglyceride concentrations at the time of the study. A significant relationship was found between body condition score and fasting serum triglyceride concentration in all dogs, but serum triglyceride concentration was not significantly associated with phenobarbital dosage or serum phenobarbital concentration.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results suggested that dogs treated long term with phenobarbital or with phenobarbital and bromide may develop hypertriglyceridemia. Fasting serum triglyceride concentration should be periodically monitored in dogs treated with phenobarbital because hypertriglyceridemia is a risk factor for pancreatitis.<\/jats:p>","DOI":"10.2460\/javma.233.8.1270","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T12:59:46Z","timestamp":1224075586000},"page":"1270-1277","source":"Crossref","is-referenced-by-count":34,"title":["Serum triglyceride concentration in dogs with epilepsy treated with phenobarbital or with phenobarbital and bromide"],"prefix":"10.2460","volume":"233","author":[{"given":"Elissa K.","family":"Kluger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Ilkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Snow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merran","family":"Govendir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Aust Vet J","first-page":"602","article-title":"Improving seizure control in dogs with refractory epilepsy using gabapentin as an adjunctive agent","volume":"83","author":"Govendir","year":"2005"},{"key":"ref2","series-title":"Aust Vet J","first-page":"23","article-title":"Effects of phenobarbitone on serum biochemical tests in dogs","volume":"78","author":"Foster","year":"2000"},{"key":"ref3","series-title":"Can Vet J","first-page":"555","article-title":"Pancreatitis associated with potassium bromide\/phenobarbital combination therapy in epileptic dogs","volume":"41","author":"Gaskill","year":"2000"},{"key":"ref4","series-title":"J Am Vet Med Assoc","first-page":"1087","article-title":"Idiopathic hyperlipoproteinemia in dogs","volume":"166","author":"Rogers","year":"1975"},{"key":"ref5","series-title":"Neurology","first-page":"883","article-title":"Neurological manifestations in hyperlipidemia","volume":"18","author":"Aarli","year":"1968"},{"issue":"1","key":"ref6","series-title":"Canine Pract","first-page":"11","article-title":"Seizures associated with hyperlipoproteinemia in a Miniature Schnauzer","volume":"17","author":"Bodkin","year":"1992"},{"key":"ref7","series-title":"Semin Vet Med Surg (Small Anim)","first-page":"292","article-title":"Evaluation of hyperlipidemias in dogs and cats","volume":"7","author":"Whitney","year":"1992"},{"key":"ref8","series-title":"J Mol Med","first-page":"753","article-title":"Lipoprotein lipase: structure, function, regulation and role in disease","volume":"80","author":"Mead","year":"2002"},{"key":"ref9","series-title":"J Biol Chem","first-page":"11553","article-title":"The lipoprotein lipase inhibitor ANGPTL3 is negatively regulated by thyroid hormone","volume":"281","author":"Fugier","year":"2006"},{"key":"ref10","series-title":"Biochem J","first-page":"165","article-title":"Effects of phenobarbital upon triacylglycerol metabolism in the rabbit","volume":"192","author":"Goldberg","year":"1980"},{"key":"ref11","series-title":"Can J Biochem","first-page":"48","article-title":"Effects of phenobarbital upon triacylglycerol metabolism in the guinea pig","volume":"59","author":"Goldberg","year":"1981"},{"key":"ref12","series-title":"Int J Clin Pharmacol Ther Toxicol","first-page":"138","article-title":"Changes in plasma activities of lipolytic enzymes and lipids of normolipidemic subjects given phenobarbital, a strong microsomal inducer, alone or in combination with fenofibrate","volume":"26","author":"Heller","year":"1988"},{"issue":"4","key":"ref13","series-title":"Canine Pract","first-page":"10","article-title":"Development and validation of a body condition score system for dogs; 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