{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:54:41Z","timestamp":1787025281907,"version":"build-2736575974"},"reference-count":19,"publisher":"American Veterinary Medical Association (AVMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2009,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    \u2014To determine clinical, histologic, and immunohistochemical findings for dogs with wart-like lesions involving the paw pads.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design<\/jats:bold>\n                    \u2014Retrospective case series.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Animals<\/jats:bold>\n                    \u201424 dogs (18 Greyhounds and 6 dogs of other breeds).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Procedures<\/jats:bold>\n                    \u2014Medical records were reviewed for information on signalment, physical examination findings, concurrent disease processes, location of all lesions, and, when available, results of histologic examination of biopsy specimens. Available biopsy specimens (n = 11) were submitted for immunohistochemical staining and a PCR assay to identify viral inclusion bodies.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    \u2014In Greyhounds, most lesions involved the pads of the third and fourth digits, had a consistent histologic appearance without evidence of inflammation, were negative for papillomavirus, and had an unsatisfactory response to treatment. In other breeds, lesions often involved the pads of non\u2013weight-bearing digits, had histologic evidence of inflammation, were positive for papillomavirus, and responded to surgical treatment.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\n                    \u2014Results suggested that wart-like lesions involving the paw pads of Greyhounds were a distinct clinical entity with features resembling porokeratosis plantaris discreta in humans. In Greyhounds, these lesions were not associated with an underlying viral etiology and, therefore, should not be considered plantar warts. Alternative treatments should be investigated because current treatments were generally unsuccessful in Greyhounds. Wart-like lesions of the paw pads in other breeds were often associated with papillomavirus, and surgical excision appeared curative.\n                  <\/jats:p>","DOI":"10.2460\/javma.234.12.1555","type":"journal-article","created":{"date-parts":[[2009,6,15]],"date-time":"2009-06-15T12:57:17Z","timestamp":1245070637000},"page":"1555-1558","source":"Crossref","is-referenced-by-count":11,"title":["Clinical, histologic, and immunohistochemical characterization of wart-like lesions on the paw pads of dogs: 24 cases (2000\u20132007)"],"prefix":"10.2460","volume":"234","author":[{"given":"Jason M.","family":"Balara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"McCarthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Kiupel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie A.","family":"Buote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabel G.","family":"Wise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger K.","family":"Maes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","article-title":"Greyhound footpad corns","author":"Veterinary"},{"key":"ref2","series-title":"Kleintierpraxis","first-page":"435","article-title":"Digital hyperkeratosis as a cause of severe lameness in two Whippets and a Greyhound","volume":"48","author":"Gortz","year":"2003"},{"key":"ref3","series-title":"Skin diseases of the dog and cat","first-page":"562","article-title":"Epidermal tumors","author":"Gross","year":"2005"},{"key":"ref4","series-title":"Skin disease: diagnosis and treatment","first-page":"186","article-title":"Viral 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Exp Dermatol","first-page":"451","article-title":"Porokeratotic palmoplantar keratoderma discreta\u2014a new entity or a variant of porokeratosis plantaris discreta?","volume":"21","author":"Korstanje","year":"1996"},{"key":"ref16","series-title":"Verh ber Erkrg Zootiere","first-page":"259","article-title":"Papillomavirus-associated basosquamous carcinoma in an Egyptian Fruit Bat (Rousettus aegyptiacus)","volume":"42","author":"McKnight","year":"2005"},{"key":"ref17","series-title":"Cancer Cells","first-page":"209","article-title":"The use of polymerase chain reaction amplification for the detection of genital human papillomaviruses","volume":"7","author":"Manos","year":"1989"},{"key":"ref18","series-title":"Cancer Res","first-page":"7515","article-title":"The prevalence of human papillomavirus genotypes in nonmelanoma skin cancers of nonimmunosuppressed individuals identifies high-risk genital types as possible risk factors","volume":"63","author":"Iftner","year":"2003"},{"key":"ref19","series-title":"Am J Vet Res","first-page":"2036","article-title":"Detection of novel papillomaviruslike sequences in paraffin-embedded specimens of invasive and in situ squamous cell carcinomas from cats","volume":"67","author":"Nespeca","year":"2006"}],"container-title":["Journal of the American Veterinary Medical 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