{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:01:45Z","timestamp":1790676105827,"version":"4.1.0"},"reference-count":25,"publisher":"American Veterinary Medical Association (AVMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2009,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To identify serum biochemical and hematologic variables, as measured in the week before parturition, that predict postpartum retention of the placenta (RP) in dairy cows.<\/jats:p>\n<jats:p><jats:bold>Design<\/jats:bold>\u2014Retrospective cohort study.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u20141,038 cows in 20 commercial dairy herds.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Serum concentrations of fatty acids (FAs), \u03b2-hydroxybutyrate, cholesterol, glucose, urea, and calcium and blood leukocyte, neutrophil, lymphocyte, monocyte, and eosinophil counts were determined. These variables were evaluated for an association with development of RP by use of a multivariate logistic regression model. Parity, season of par-turition, existence of twins or dystocia, body condition score, and vitamin E treatment were included in the model as covariates.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014High serum concentrations of cholesterol and FAs were associated with an increased odds of RP. There was a 5% relative increase in the odds of RP for each 0.1 mmol\/L increase in cholesterol or FAs concentration in the week before parturition. Season of parturition and twinning were also identified as risk factors.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014These associations indicated that prepartum energy metabolism contributes to the development of RP. Serum concentrations of cholesterol and FAs may be useful to identify cows with a metabolic abnormality or energy imbalance that might predispose them to RP and should be interpreted in conjunction with clinical risk factors such as twinning, dystocia, or parturient paresis.<\/jats:p>","DOI":"10.2460\/javma.234.6.790","type":"journal-article","created":{"date-parts":[[2009,3,15]],"date-time":"2009-03-15T08:02:31Z","timestamp":1237104151000},"page":"790-793","source":"Crossref","is-referenced-by-count":38,"title":["Evaluation of prepartum serum cholesterol and fatty acids concentrations as predictors of postpartum retention of the placenta in dairy cows"],"prefix":"10.2460","volume":"234","author":[{"given":"Gerardo F.","family":"Quiroz-Rocha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"LeBlanc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Duffield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken E.","family":"Leslie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Vet Rec","first-page":"53","article-title":"Economic and reproductive consequences of retained placenta in dairy 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