{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:41:54Z","timestamp":1770219714919,"version":"3.49.0"},"reference-count":25,"publisher":"American Veterinary Medical Association (AVMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2009,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Case Description<\/jats:bold>\u2014A 4-year-old spayed female mixed-breed dog with a history of allergic skin disease was examined because of regurgitation, coughing, and dysphagia that began 15 days after abdominal surgery for correction of gastric dilatation and volvulus.<\/jats:p>\n<jats:p><jats:bold>Clinical Findings<\/jats:bold>\u2014Severe diffuse esophagitis, esophageal dysmotility, and a benign esophageal stricture at the level of the base of the heart were identified via contrast videofluoroscopy and esophagoscopy. Severe diffuse eosinophilic ulcerative esophagitis was confirmed by histologic examination of esophageal biopsy specimens and cytologic evaluation of specimens obtained by use of a cytology brush. Esophageal eosinophils were evident (14% to 50% of the inflammatory cell population and &gt; 25 eosinophils\/hpf).<\/jats:p>\n<jats:p><jats:bold>Treatment and Outcome<\/jats:bold>\u2014No clinical or endoscopic improvement was evident after treatment with antireflux medications, including a proton-pump inhibitor, following an initial esophageal bougienage procedure. An excellent response characterized by resolution of dysphagia and regurgitation with marked improvement of the esophageal mucosa was evident following intralesional and systemic administration of glucocorticoids, 2 additional esophageal bougienage procedures, and feeding of an elimination diet.<\/jats:p>\n<jats:p><jats:bold>Clinical Relevance<\/jats:bold>\u2014To our knowledge, the information reported here is the first description of eosinophilic esophagitis (EE) in a dog. Many similarities exist between the condition in the dog reported here and EE in humans. This clinical report highlights the need to consider EE as a differential diagnosis for esophagitis and esophageal strictures in dogs. When appropriate, esophageal biopsy or cytologic specimens should be obtained and examined to investigate the possibility of EE.<\/jats:p>","DOI":"10.2460\/javma.235.1.61","type":"journal-article","created":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T07:08:51Z","timestamp":1246432131000},"page":"61-65","source":"Crossref","is-referenced-by-count":13,"title":["Eosinophilic esophagitis in a dog"],"prefix":"10.2460","volume":"235","author":[{"given":"Michael J.","family":"Mazzei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally A.","family":"Bissett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. Marcia","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer A.","family":"Neel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Textbook of veterinary internal medicine","first-page":"1298","article-title":"Diseases of the esophagus","author":"Jergens","year":"2005"},{"key":"ref2","series-title":"Vet Clin North Am Small Anim Pract","first-page":"945","article-title":"Esophagitis and esophageal strictures","volume":"33","author":"Sellon","year":"2003"},{"key":"ref3","series-title":"Gastroenterology","first-page":"380","article-title":"Canine Zollinger-Ellison syndrome","volume":"72","author":"Straus","year":"1977"},{"key":"ref4","series-title":"J Vet Intern 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gastroesophageal reflux disease: a study of 41 patients","volume":"19","author":"Parfitt","year":"2006"},{"key":"ref19","series-title":"Mod Pathol","first-page":"619","article-title":"The histologic development of acid-induced esophagitis in the cat","volume":"3","author":"Geisinger","year":"1990"},{"key":"ref20","series-title":"Scand J Gastroenterol","first-page":"904","article-title":"Chronic oesophagitis in the cat","volume":"36","author":"Poorkhalkali","year":"2001"},{"key":"ref21","series-title":"Dis Esophagus","first-page":"89","article-title":"Gastroesophageal reflux triggers proliferative activity of the submucosal glands in the canine esophagus","volume":"11","author":"Van Nieuwenhove","year":"1998"},{"key":"ref22","series-title":"Gastroenterology","first-page":"276","article-title":"Inflammatory and structural changes in the opossum esophagus after resection of the cardia","volume":"82","author":"Schulze-Delrieu","year":"1982"},{"key":"ref23","series-title":"Gastrointest 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