{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T16:23:03Z","timestamp":1793809383648,"version":"4.6.1"},"reference-count":39,"publisher":"American Veterinary Medical Association (AVMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2009,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Case Description<\/jats:bold>\u2014A 7-month-old neutered male ferret was evaluated for episodic pelvic limb weakness of 2 weeks' duration.<\/jats:p>\n<jats:p><jats:bold>Clinical Findings<\/jats:bold>\u2014Neurologic examination revealed flaccid tetraparesis with decreased spinal reflexes suggestive of a neuromuscular disease. Results of hematologic and CSF analyses, thoracic radiography, and abdominal ultrasonography were unremarkable. Electrodiagnostic testing revealed subtle spontaneous activity localized to pelvic limb interosseous muscles, unremarkable motor nerve conduction velocities, and lower than typical compound muscle action potential (CMAP) amplitude for tibial nerve stimulation only. A severe decremental response of the CMAP was detected with repetitive nerve stimulation (45.5% at the third ulnar nerve). An esophagogram revealed mild megaesophagus. Intravenous neostigmine methylsulfate administration resulted in immediate resolution of muscle weakness. Cross-reacting anti-acetylcholine receptor (AChR) antibodies were detected in serum (0.35 nmol\/L) by use of a canine- and feline-specific muscle extract. Clinical signs and ancillary test results were diagnostic of acquired myasthenia gravis.<\/jats:p>\n<jats:p><jats:bold>Treatment and Outcome<\/jats:bold>\u2014Pyridostigmine bromide was administered (1 mg\/kg [0.45 mg\/lb], PO, q 8 h), resulting in complete remission of clinical signs. However, 1 month after the diagnosis, the ferret was euthanized because of recurrence of weakness despite anticholinesterase treatment.<\/jats:p>\n<jats:p><jats:bold>Clinical Relevance<\/jats:bold>\u2014To the authors' knowledge, this is the first report of acquired myasthenia gravis in a ferret and the first identification of anti-AChR antibodies in this species. Autoimmune myasthenia gravis should be considered in ferrets when weakness and flaccid paresis suggest a neuromuscular disease. Electrodiagnostic testing, anticholinesterase challenge, and AChR antibody titer determination were helpful for diagnosis of this condition.<\/jats:p>","DOI":"10.2460\/javma.235.12.1462","type":"journal-article","created":{"date-parts":[[2009,12,15]],"date-time":"2009-12-15T14:02:54Z","timestamp":1260885774000},"page":"1462-1466","source":"Crossref","is-referenced-by-count":21,"title":["Autoimmune myasthenia gravis in a ferret"],"prefix":"10.2460","volume":"235","author":[{"given":"J\u00e9r\u00f4me","family":"Couturier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh","family":"Huynh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Boussarie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Cauzinille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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Assoc","first-page":"694","article-title":"Congenital myasthenia gravis in 13 smooth fox terriers","volume":"182","author":"Miller","year":"1983"},{"key":"ref6","series-title":"Acta Vet Scand","first-page":"89","article-title":"Congenital myasthenic syndrome in the dog breed Gammel Dansk Honsehund: clinical, electrophysiological, pharmacological and immunological comparison with acquired myasthenia gravis","volume":"30","author":"Flagstad","year":"1989"},{"key":"ref7","series-title":"J Vet Intern Med","first-page":"920","article-title":"Congenital myasthenia gravis in Smooth-Haired Miniature Dachshund dogs","volume":"19","author":"Dickinson","year":"2005"},{"key":"ref8","series-title":"Vet Rec","first-page":"526","article-title":"Suspected congenital myasthenia gravis in Brahman calves","volume":"143","author":"Thompson","year":"1998"},{"key":"ref9","series-title":"J Am Vet Med Assoc","first-page":"55","article-title":"Risk factors for acquired myasthenia gravis in cats: 105 cases (1986\u20131998)","volume":"216","author":"Shelton","year":"2000"},{"key":"ref10","series-title":"J Vet Intern Med","first-page":"231","article-title":"Myasthenia gravis-like syndrome in a Hereford heifer","volume":"22","author":"Wise","year":"2008"},{"key":"ref11","series-title":"J Zoo Wildl Med","first-page":"409","article-title":"Myasthenia gravis in a polar bear (Ursus maritimus)","volume":"35","author":"Kenny","year":"2004"},{"key":"ref12","series-title":"Proceedings","first-page":"154","article-title":"Myasthenia gravis in a Siberian tiger","author":"Wallace","year":"1994"},{"key":"ref13","series-title":"J Vet Intern Med","first-page":"50","article-title":"Clinical forms of acquired myasthenia gravis in dogs: 25 cases (1988\u20131995)","volume":"11","author":"Dewey","year":"1997"},{"key":"ref14","series-title":"J Am Vet Med Assoc","first-page":"830","article-title":"Acute fulminating myasthenia gravis in five dogs","volume":"212","author":"King","year":"1998"},{"key":"ref15","series-title":"J Small Anim Pract","first-page":"368","article-title":"Myasthenia gravis: lessons from the past 10 years","volume":"39","author":"Shelton","year":"1998"},{"key":"ref16","series-title":"J Am Vet Med Assoc","first-page":"1428","article-title":"Risk factors for acquired myasthenia gravis in dogs: 1,154 cases (1991\u20131995)","volume":"211","author":"Shelton","year":"1997"},{"key":"ref17","series-title":"J Am Vet Med Assoc","first-page":"444","article-title":"Megaesophagus in nine ferrets","volume":"205","author":"Blanco","year":"1994"},{"key":"ref18","series-title":"Neurology","first-page":"1417","article-title":"Canine and human myasthenia gravis autoantibodies recognize similar regions on the acethylcholine receptor","volume":"38","author":"Shelton","year":"1988"},{"key":"ref19","series-title":"Eur J Neurol","first-page":"413","article-title":"Seronegative myasthenia gravis: disease severity and prognosis","volume":"12","author":"Romi","year":"2005"},{"key":"ref20","series-title":"Vet Clin North Am Small Anim Pract","first-page":"31","article-title":"Electrophysiology in neuromuscular disease","volume":"32","author":"Cuddon","year":"2002"},{"key":"ref21","series-title":"Muscle Nerve","first-page":"577","article-title":"Diagnostic difficulties in myasthenia gravis","volume":"21","author":"Maher","year":"1998"},{"key":"ref22","series-title":"Muscle Nerve","first-page":"394","article-title":"Myasthenia gravis presenting with unusual neurogenic muscle atrophy","volume":"36","author":"Samukari","year":"2007"},{"key":"ref23","series-title":"Vet Clin North Am Small Anim Pract","first-page":"1525","article-title":"Therapeutic options for neuromuscular diseases","volume":"34","author":"Kent","year":"2004"},{"key":"ref24","series-title":"Vet Pathol","first-page":"25","article-title":"Myofasciitis in the domestic ferret","volume":"44","author":"Garner","year":"2007"},{"key":"ref25","series-title":"Vet Clin North Am Exot Anim Pract","first-page":"759","article-title":"Clinical neurology of ferrets","volume":"10","author":"Diaz-Figueroa","year":"2007"},{"key":"ref26","series-title":"Transplantation","first-page":"21","article-title":"Myasthenia gravis and polymyositis in a dog following fetal hematopoietic cell transplantation","volume":"41","author":"Cain","year":"1986"},{"key":"ref27","series-title":"Can Vet J","first-page":"480","article-title":"Myasthenia gravis and masticatory muscle myositis in a dog","volume":"44","author":"Clooten","year":"2003"},{"key":"ref28","series-title":"J Small Anim Pract","first-page":"593","article-title":"Autoimmune myasthenia gravis and dysautonomia in a dog","volume":"49","author":"Gajanayake","year":"2008"},{"key":"ref29","series-title":"Prog Vet Neurol","first-page":"117","article-title":"Neuromuscular dysfunction in five dogs with acquired myasthenia gravis and presumptive hypothyroidism","volume":"6","author":"Dewey","year":"1995"},{"key":"ref30","series-title":"Am J Vet Res","first-page":"32","article-title":"Thyroid and adrenal function tests in adult male ferrets","volume":"51","author":"Heard","year":"1990"},{"issue":"2","key":"ref31","series-title":"Exotic DVM","first-page":"5","article-title":"Pemphigus foliaceus-like skin disease in a ferret","volume":"9","author":"Eckermann-Ross","year":"2007"},{"key":"ref32","series-title":"Vet Immunol Immunopathol","first-page":"97","article-title":"Titin and ryanodine receptor autoantibodies in dogs with thymoma and late-onset myasthenia gravis","volume":"78","author":"Shelton","year":"2001"},{"key":"ref33","series-title":"J Am Vet Med Assoc","first-page":"488","article-title":"Acquired myasthenia gravis and cholangiocellular carcinoma in a dog","volume":"197","author":"Krotje","year":"1990"},{"key":"ref34","series-title":"J Am Vet Med Assoc","first-page":"226","article-title":"Osteogenic sarcoma and myasthenia gravis in a dog","volume":"197","author":"Moore","year":"1990"},{"key":"ref35","series-title":"J Small Anim Pract","first-page":"348","article-title":"Myasthenia gravis associated with cutaneous lymphoma in a dog","volume":"41","author":"Ridyard","year":"2000"},{"key":"ref36","series-title":"Lab Anim Sci","first-page":"363","article-title":"Thymoma in two ferrets","volume":"45","author":"Taylor","year":"1995"},{"key":"ref37","series-title":"Textbook of veterinary internal medicine","first-page":"836","article-title":"Multifocal neurologic disease","author":"Bagley","year":"2005"},{"key":"ref38","series-title":"J Wildl Dis","first-page":"787","article-title":"Toxoplasma gondii infections in captive black-footed ferrets (Mustela nigripes), 1992\u20131998: clinical signs, serology, pathology, and prevention","volume":"39","author":"Burns","year":"2003"},{"key":"ref39","series-title":"Neurology","first-page":"2139","article-title":"Spontaneous remission in canine 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