{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:16:46Z","timestamp":1791281806539,"version":"4.1.0"},"reference-count":17,"publisher":"American Veterinary Medical Association (AVMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2009,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Case Description<\/jats:bold>\u2014A 12-year-old 21.9-kg (48.48-lb) spayed female Alaskan Malamute with a long-term history of panting, polydypsia and polyuria, weight loss, hind limb weakness, and a decrease in appetite was evaluated for hypertension.<\/jats:p>\n<jats:p><jats:bold>Clinical Findings<\/jats:bold>\u2014Use of Doppler sphygmomanometry revealed a systolic blood pressure of 250 mm Hg (mean value for 5 consecutive measurements). Palpation of the ventral cervical region revealed a fixed asymmetric mass in the area of the lobes of the thyroid gland. The portion of the mass on the right side was approximately 2 \u00d7 2 cm, whereas the portion of the mass on the left side was approximately 1 \u00d7 1.5 cm. Hyperthyroidism was diagnosed on the basis of high serum thyroxine concentrations. Thyroidectomy of both lobes of the gland was performed. Histologic examination revealed a bilateral, multilobulated, and encapsulated thyroid gland adenocarcinoma.<\/jats:p>\n<jats:p><jats:bold>Treatment and Outcome<\/jats:bold>\u2014Thyroidectomy of both lobes of the gland was performed with clinical resolution of hypertension. The dog was treated postoperatively with chemotherapeutics, including doxorubicin and carboplatin, and external beam radiation. Calcium and thyroxine homeostasis fluctuated; however, the dog finally achieved concentrations within the respective reference ranges through the administration of calcitriol, calcium carbonate, and levothyroxine.<\/jats:p>\n<jats:p><jats:bold>Clinical Relevance<\/jats:bold>\u2014This report describes concurrent hypertension in a dog with a functional thyroid gland adenocarcinoma with subsequent return of blood pressure values to within reference ranges after thyroidectomy.<\/jats:p>","DOI":"10.2460\/javma.235.12.1474","type":"journal-article","created":{"date-parts":[[2009,12,15]],"date-time":"2009-12-15T14:02:54Z","timestamp":1260885774000},"page":"1474-1479","source":"Crossref","is-referenced-by-count":19,"title":["Systemic hypertension in a dog with a functional thyroid gland adenocarcinoma"],"prefix":"10.2460","volume":"235","author":[{"given":"Andrew C.","family":"Simpson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"McCown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Can Vet J","first-page":"125","article-title":"Thyroid carcinoma and hyperthyroidism in a dog","volume":"43","author":"Bezzola","year":"2002"},{"key":"ref2","series-title":"Neurosci Behav Physiol","first-page":"99","article-title":"Investigation of the hypothalamohypophyseal neurosecretory system in dogs with experimental thyrogenic hypertension","volume":"3","author":"Zhukova","year":"1969"},{"key":"ref3","series-title":"Vet Clin North Am Small Anim Pract","first-page":"723","article-title":"Cardiovascular and renal manifestations of hyperthyroidism","volume":"37","author":"Syme","year":"2007"},{"key":"ref4","series-title":"J Vet Intern Med","first-page":"58","article-title":"Hypertension in cats with chronic renal failure or 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thyroid carcinoma in dogs by surgical resection alone: 20 cases (1981\u20131989)","volume":"206","author":"Klein","year":"1995"},{"key":"ref15","series-title":"Biochim Biophys Acta","first-page":"331","article-title":"Molecular basis of renal handling of calcium in response to thyroid hormone status of rat","volume":"1586","author":"Kumar","year":"2002"},{"key":"ref16","series-title":"Biochim Biophys Acta","first-page":"185","article-title":"Thyroid hormones stimulate calcium transport systems in rat intestine","volume":"1639","author":"Kumar","year":"2003"},{"key":"ref17","series-title":"Acta Endocrinol (Copenh)","first-page":"42","article-title":"Thyroid function and bone turnover","volume":"104","author":"Bijlsma","year":"1983"}],"container-title":["Journal of the American Veterinary Medical 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