{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:09:15Z","timestamp":1790208555227,"version":"4.1.0"},"reference-count":31,"publisher":"American Veterinary Medical Association (AVMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2010,4,1]]},"abstract":"Abstract<\/jats:title>\nCase Description<\/jats:bold>\u2014A 4-year-old castrated male domestic ferret from central Massachusetts was evaluated for weight loss over a 1.5-month period and for 2 days of retching, diarrhea, and signs of lethargy. It had been housed indoors, with 2 other ferrets, 2 cats, and humans that lacked signs or symptoms of disease.<\/jats:p>\nClinical Findings<\/jats:bold>\u2014Physical examination revealed a thin body condition, tachypnea, an increase in respiratory effort, and retching. Splenomegaly was detected during abdominal palpation. Clinicopathologic analysis revealed lymphopenia, lactic acidosis, hypoglycemia, hypocalcemia, hypoalbuminemia, and hyperglobulinemia. A pulmonary bronchointerstitial pattern was evident on radiographs, and abdominal ultrasonography revealed a suspected pancreatic mass and mesenteric lymphadenopathy.<\/jats:p>\nTreatment and Outcome<\/jats:bold>\u2014After 2 weeks of medical treatment and once clinical signs resolved, an exploratory laparotomy was performed and a lymph node biopsy specimen was collected. Histologic evaluation of the specimen revealed Cryptococcus<\/jats:italic>-like organisms. Antifungal treatment was initiated with itraconazole (PO) and amphotericin B (IV). The ferret died after 2 days of treatment. A full necropsy was performed, revealing multicentric cryptococcosis affecting the lungs, brain, spleen, and multiple lymph nodes. Paraffin-embedded, formalin-fixed lung tissue was submitted for DNA extraction, and the organism was identified as Cryptococcus neoformans<\/jats:italic> var grubii<\/jats:italic>.<\/jats:p>\nClinical Relevance<\/jats:bold>\u2014To the authors' knowledge, this is the first report of disseminated cryptococcosis in a North American ferret. This case is unique in that the ferret lived indoors, in a geographic region in which reports of cryptococcosis are rare. The genotyping technique used to identify the Cryptococcus<\/jats:italic> strain can aid in better understanding the epidemiology of cryptococcosis.<\/jats:p>","DOI":"10.2460\/javma.236.7.770","type":"journal-article","created":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T07:13:24Z","timestamp":1270106004000},"page":"770-774","source":"Crossref","is-referenced-by-count":27,"title":["Disseminated, histologically confirmed Cryptococcus spp infection in a domestic ferret"],"prefix":"10.2460","volume":"236","author":[{"given":"David","family":"Eshar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola M.","family":"Parry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misty J.","family":"Williams-Fritze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Bradway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Exotic animal formulary","first-page":"464","author":"Carpenter","year":"2005"},{"key":"ref2","series-title":"FEMS Yeast Res","first-page":"377","article-title":"The internal transcribed spacers and 5.8S rRNA gene show extensive diversity among isolates of the Cryptococcus neoformans species complex","volume":"4","author":"Katsu","year":"2004"},{"key":"ref3","series-title":"Nucleic Acids Res","first-page":"4673","article-title":"ClustalW: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix 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