{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:48:38Z","timestamp":1791053318558,"version":"4.1.0"},"reference-count":29,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2010,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To determine whether monthly topical administration of a combination of 10% imidacloprid and 1% moxidectin would lessen flea (<jats:italic>Ctenocephalides felis<\/jats:italic>) transmission of <jats:italic>Bartonella henselae<\/jats:italic> among cats.<\/jats:p>\n<jats:p><jats:bold>Design<\/jats:bold>\u2014Controlled trial.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u201418 specific pathogen\u2013free cats housed in 3 groups of 6.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u20143 enclosures were separated by mesh to allow fleas to pass among groups yet prevent cats from contacting one another. One group was inoculated IV with <jats:italic>B henselae<\/jats:italic>, and after infection was confirmed, the cats were housed in the middle enclosure. This infected group was flanked by a group that was treated topically with 10% imidacloprid\u20131% moxidectin monthly for 3 months and by an untreated group. On days 0, 15, 28, and 42, 100 fleas\/cat were placed on each of the 6 cats in the <jats:italic>B henselae<\/jats:italic>\u2013infected group. Blood samples were collected from all cats weekly for detection of <jats:italic>Bartonella<\/jats:italic> spp via PCR assay, bacterial culture, and serologic assay.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014<jats:italic>B henselae<\/jats:italic> infection was confirmed in the cats infected IV and in all untreated cats after flea exposure; none of the cats treated with the imidacloprid-moxidectin combination became infected.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014In this setting, monthly topical administration of 10% imidacloprid\u20131% moxidectin reduced flea infestation, compared with infestation in untreated cats, and thus prevented flea transmission of <jats:italic>B henselae<\/jats:italic> to treated cats. Regular monthly use of this flea control product in cats may lessen the likelihood of humans acquiring <jats:italic>B henselae<\/jats:italic> infection.<\/jats:p>","DOI":"10.2460\/javma.236.8.869","type":"journal-article","created":{"date-parts":[[2010,4,15]],"date-time":"2010-04-15T07:11:31Z","timestamp":1271315491000},"page":"869-873","source":"Crossref","is-referenced-by-count":65,"title":["Evaluation of topical application of 10% imidacloprid\u20131% moxidectin to prevent Bartonella henselae transmission from cat fleas"],"prefix":"10.2460","volume":"236","author":[{"given":"Christina A.","family":"Bradbury","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Lappin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Proceedings","first-page":"2978","article-title":"Immunofluorescent detection of intraerythrocytic 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