{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T13:31:35Z","timestamp":1786973495032,"version":"build-2736575974"},"reference-count":34,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2010,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To determine whether changes in presurgical plasma lactate concentration (before and after initial fluid resuscitation and gastric decompression) were associated with short-term outcome for dogs with gastric dilatation-volvulus (GDV).<\/jats:p>\n<jats:p><jats:bold>Design<\/jats:bold>\u2014Retrospective case series.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u201464 dogs.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Medical records were reviewed, and signalment, history, resuscitative treatments, serial presurgical lactate concentrations, surgical findings, and short-term outcome were obtained for dogs with confirmed GDV.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u201436 of 40 (90%) dogs with an initial lactate concentration \u2264 9.0 mmol\/L survived, compared with only 13 of 24 (54%) dogs with a high initial lactate (HIL) concentration (&gt; 9.0 mmol\/L). Within HIL dogs, there was no difference in mean \u00b1 SD initial lactate concentration between survivors and nonsurvivors (10.6 \u00b1 2.3 mmol\/L vs 11.2 \u00b1 2.3 mmol\/L, respectively); however, there were significant differences in post-treatment lactate concentration, absolute change in lactate concentration, and percentage change in lactate concentration following resuscitative treatment. By use of optimal cutoff values within HIL dogs, survival rates for dogs with final lactate concentration &gt; 6.4 mmol\/L (23%), absolute change in lactate concentration \u2264 4 mmol\/L (10%), or percentage change in lactate concentration \u2264 42.5% (15%) were significantly lower than survival rates for dogs with a final lactate concentration \u2264 6.4 mmol\/L (91%), absolute change in lactate concentration &gt; 4 mmol\/L (86%), or percentage change in lactate concentration &gt; 42.5% (100%).<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Calculating changes in plasma lactate concentration following initial treatment in dogs with GDV may assist in determining prognosis and identifying patients that require more aggressive treatment.<\/jats:p>","DOI":"10.2460\/javma.236.8.892","type":"journal-article","created":{"date-parts":[[2010,4,15]],"date-time":"2010-04-15T07:11:31Z","timestamp":1271315491000},"page":"892-897","source":"Crossref","is-referenced-by-count":100,"title":["Association between outcome and changes in plasma lactate concentration during presurgical treatment in dogs with gastric dilatation-volvulus: 64 cases (2002\u20132008)"],"prefix":"10.2460","volume":"236","author":[{"given":"Laurie A.","family":"Zacher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott P.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond K.","family":"Kudej","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Fluid therapy in small animal practice","first-page":"486","article-title":"Fluid therapy during anesthesia and surgery","author":"Muir","year":"1992"},{"key":"ref2","series-title":"J Am Vet Med Assoc","first-page":"49","article-title":"Plasma lactate concentration as a predictor of gastric necrosis and survival among dogs with gastric dilatation-volvulus: 102 cases (1995\u20131998)","volume":"215","author":"de Papp","year":"1999"},{"key":"ref3","series-title":"J Am Anim Hosp Assoc","first-page":"253","article-title":"A prospective study of survival and recurrence following the acute gastric dilatation-volvulus syndrome in 136 dogs","volume":"34","author":"Glickman","year":"1998"},{"key":"ref4","series-title":"J Am Vet Med Assoc","first-page":"1855","article-title":"Factors associated with perioperative mortality in dogs with surgically managed gastric dilatation-volvulus: 137 cases (1988\u20131993)","volume":"208","author":"Brourman","year":"1996"},{"key":"ref5","series-title":"J Am Vet Med Assoc","first-page":"460","article-title":"Canine gastric dilatation\/volvulus syndrome in a veterinary critical care unit: 295 cases (1986\u20131992)","volume":"207","author":"Brockman","year":"1995"},{"key":"ref6","series-title":"J Am Vet Med Assoc","first-page":"1465","article-title":"Analysis of risk factors for gastric dilatation and dilatation-volvulus in dogs","volume":"204","author":"Glickman","year":"1994"},{"key":"ref7","series-title":"J Am Vet Med Assoc","first-page":"1334","article-title":"Evaluation of lidocaine treatment and risk factors for death associated with gastric dilatation and volvulus in dogs: 112 cases (1997\u20132005)","volume":"230","author":"Buber","year":"2007"},{"key":"ref8","series-title":"J Am Vet Med Assoc","first-page":"1934","article-title":"Risk factors associated with short-term outcome and development of perioperative complications in dogs undergoing surgery because of gastric dilatation-volvulus: 166 cases (1992\u20132003)","volume":"229","author":"Beck","year":"2006"},{"key":"ref9","series-title":"Vet Surg","first-page":"185","article-title":"Partial gastrectomy as treatment of gastric volvulus\u2014results in 30 dogs","volume":"14","author":"Matthiesen","year":"1985"},{"key":"ref10","series-title":"Ann Surg","first-page":"308","article-title":"Blood lactate in the prognosis of various forms of shock","volume":"173","author":"Vitek","year":"1971"},{"key":"ref11","series-title":"Circulation","first-page":"989","article-title":"Experimental and clinical studies on lactate and pyruvate as indicators of the severity of acute circulatory failure (shock)","volume":"41","author":"Weil","year":"1970"},{"key":"ref12","series-title":"Lancet","first-page":"505","article-title":"Lactate is an unreliable indicator of tissue hypoxia in injury or sepsis","volume":"354","author":"James","year":"1999"},{"key":"ref13","series-title":"Crit Care Med","first-page":"1637","article-title":"Early lactate clearance is associated with improved outcome in severe sepsis and septic shock","volume":"32","author":"Nguyen","year":"2004"},{"key":"ref14","series-title":"Am J Surg","first-page":"221","article-title":"Serial blood lactate levels can predict the development of multiple organ failure following septic shock","volume":"171","author":"Bakker","year":"1996"},{"key":"ref15","series-title":"Crit Care Med","first-page":"154","article-title":"Prognostic value of blood lactate, base deficit, and oxygen-derived variables in an LD50 model of penetrating trauma","volume":"27","author":"Moomey","year":"1999"},{"key":"ref16","series-title":"Am J Vet Res","first-page":"1969","article-title":"Prognostic index for acute abdominal crisis (colic) in horses","volume":"49","author":"Orsini","year":"1988"},{"key":"ref17","series-title":"J Vet Emerg Crit Care","first-page":"117","article-title":"Increased lactate concentrations in ill and injured dogs","volume":"8","author":"Lagutchik","year":"1998"},{"key":"ref18","series-title":"Vet Surg","first-page":"563","article-title":"Plasma lactate as a predictor of colonic viability and survival after 360 degrees volvulus of the ascending colon in horses","volume":"36","author":"Johnston","year":"2007"},{"key":"ref19","series-title":"Intensive Care Med","first-page":"1144","article-title":"Does tissue acidosis in sepsis indicate tissue hypoperfusion?","volume":"22","author":"Fink","year":"1996"},{"key":"ref20","series-title":"Ann Surg","first-page":"97","article-title":"Lactic acidosis during sepsis is related to increased pyruvate production, not deficits in tissue oxygen availability","volume":"224","author":"Gore","year":"1996"},{"key":"ref21","series-title":"Intensive Care Med","first-page":"6","article-title":"Lactic acidosis in sepsis: a commentary","volume":"22","author":"Gutierrez","year":"1996"},{"key":"ref22","series-title":"Burns","first-page":"986","article-title":"Lactate: early predictor of morbidity and mortality in patients with severe burns","volume":"31","author":"Kamolz","year":"2005"},{"key":"ref23","series-title":"Crit Care Med","first-page":"449","article-title":"Serial lactate determinations during circulatory shock","volume":"11","author":"Vincent","year":"1983"},{"key":"ref24","series-title":"Crit Care","first-page":"R60","article-title":"Occult hypoperfusion is associated with increased mortality in hemodynamically stable, high-risk, surgical patients","volume":"8","author":"Meregalli","year":"2004"},{"key":"ref25","series-title":"J Trauma","first-page":"584","article-title":"Lactate clearance and survival following injury","volume":"35","author":"Abramson","year":"1993"},{"key":"ref26","series-title":"Am J Surg","first-page":"481","article-title":"Prolonged lactate clearance is associated with increased mortality in the surgical intensive care unit","volume":"182","author":"McNelis","year":"2001"},{"key":"ref27","series-title":"Am J Surg","first-page":"485","article-title":"Serum lactate and base deficit as predictors of mortality and morbidity","volume":"185","author":"Husain","year":"2003"},{"key":"ref28","series-title":"Am J Vet Res","first-page":"521","article-title":"Effect of sampling site, repeated sampling, pH, and PCO2 on plasma lactate concentration in healthy dogs","volume":"60","author":"Hughes","year":"1999"},{"key":"ref29","series-title":"Vet Surg","first-page":"97","article-title":"Development of a colic severity score for predicting the outcome of equine colic","volume":"24","author":"Furr","year":"1995"},{"key":"ref30","series-title":"J Vet Intern Med","first-page":"471","article-title":"Prognostic value of blood lactate, blood glucose, and hematocrit in canine babesiosis","volume":"18","author":"Nel","year":"2004"},{"key":"ref31","series-title":"Vet Clin Pathol","first-page":"234","article-title":"Serial blood lactate concentrations in systemically ill dogs","volume":"36","author":"Stevenson","year":"2007"},{"key":"ref32","series-title":"J Am Anim Hosp Assoc","first-page":"925","article-title":"The gastric dilatation-volvulus complex: medical and surgical considerations","volume":"19","author":"Matthiesen","year":"1983"},{"key":"ref33","series-title":"Shock","first-page":"520","article-title":"Fluid resuscitation in severe sepsis and septic shock: albumin, hydroxyethyl starch, gelatin or Ringer's lactate\u2014does it really make a difference?","volume":"27","author":"Su","year":"2007"},{"key":"ref34","series-title":"Crit Care Med","first-page":"218","article-title":"Unreliability of blood pressure and heart rate to evaluate cardiac output in emergency resuscitation and critical illness","volume":"21","author":"Wo","year":"1993"}],"container-title":["Journal of the American Veterinary Medical 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