{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T10:59:08Z","timestamp":1793444348418,"version":"4.5.0"},"reference-count":35,"publisher":"American Veterinary Medical Association (AVMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2011,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    \u2014To compare sickness behaviors (SB) in response to unusual external events (UEE) in healthy cats with those of cats with feline interstitial cystitis (FIC).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design<\/jats:bold>\n                    \u2014Prospective observational study.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Animals<\/jats:bold>\n                    \u201412 healthy cats and 20 donated cats with FIC.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Procedures<\/jats:bold>\n                    \u2014Cats were housed in a vivarium. Sickness behaviors referable to the gastrointestinal and urinary tracts, the skin, and behavior problems were recorded by a single observer for 77 weeks. Instances of UEE (eg, changes in caretakers, vivarium routine, and lack of interaction with the investigator) were identified during 11 of the 77 weeks. No instances of UEE were identified during the remaining 66 weeks, which were considered control weeks.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    \u2014An increase in age and exposure to UEE, but not disease status, significantly increased total number of SB when results were controlled for other factors. Evaluation of individual SB revealed a protective effect of food intake for healthy males. An increase in age conferred a small increase in relative risk (RR) for upper gastrointestinal tract signs (RR, 1.2) and avoidance behavior (1.7). Exposure to UEE significantly increased the RR for decreases in food intake (RR, 9.3) and for no eliminations in 24 hours (6.4). Exposure to UEE significantly increased the RR for defecation (RR, 9.8) and urination (1.6) outside the litter box.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\n                    \u2014SB, including some of the most commonly observed abnormalities in client-owned cats, were observed after exposure to UEE in both groups. Because healthy cats and cats with FIC were comparably affected by UEE, clinicians should consider the possibility of exposure to UEE in cats evaluated for these signs.\n                  <\/jats:p>","DOI":"10.2460\/javma.238.1.67","type":"journal-article","created":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T03:02:51Z","timestamp":1293850971000},"page":"67-73","source":"Crossref","is-referenced-by-count":161,"title":["Sickness behaviors in response to unusual external events in healthy cats and cats with feline interstitial cystitis"],"prefix":"10.2460","volume":"238","author":[{"given":"Judi L.","family":"Stella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda K.","family":"Lord","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. A. Tony","family":"Buffington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"J Am Vet Med Assoc","first-page":"582","article-title":"Risk factors for relinquishment of cats to an animal shelter","volume":"209","author":"Patronek","year":"1996"},{"key":"ref2","series-title":"J Appl Anim Welf Sci","first-page":"93","article-title":"Behavioral reasons for relinquishment of dogs and cats to 12 shelters","volume":"3","author":"Salman","year":"2000"},{"key":"ref3","series-title":"J Am Vet Med Assoc","first-page":"1336","article-title":"Health status and population characteristics of dogs and cats examined at private veterinary practices in the United States","volume":"214","author":"Lund","year":"1999"},{"key":"ref4","series-title":"Textbook of veterinary internal medicine","first-page":"1828","article-title":"Feline lower urinary tract diseases","author":"Westropp","year":"2005"},{"key":"ref5","series-title":"J Am Vet Med Assoc","first-page":"682","article-title":"Feline interstitial cystitis","volume":"215","author":"Buffington","year":"1999"},{"key":"ref6","series-title":"Urology","first-page":"52","article-title":"Antecedent nonbladder syndromes in case-control study of interstitial cystitis\/painful bladder syndrome","volume":"73","author":"Warren","year":"2009"},{"key":"ref7","series-title":"J Pain","first-page":"777","article-title":"Understanding fibromyalgia: lessons from the broader pain research community","volume":"10","author":"Williams","year":"2009"},{"key":"ref8","series-title":"J Am Vet Med Assoc","first-page":"722","article-title":"Risk factors associated with clinical signs of lower urinary tract disease in indoor-housed cats","volume":"228","author":"Buffington","year":"2006"},{"key":"ref9","series-title":"Am J Vet Res","first-page":"731","article-title":"Evaluation of the effects of stress in cats with idiopathic cystitis","volume":"67","author":"Westropp","year":"2006"},{"key":"ref10","series-title":"J Feline Med Surg","first-page":"261","article-title":"Clinical evaluation of multimodal environmental modification (MEMO) in the management of cats with idiopathic cystitis","volume":"8","author":"Buffington","year":"2006"},{"key":"ref11","series-title":"Appl Anim Behav Sci","first-page":"345","article-title":"Housing conditions and behavioural problems of indoor cats as assessed by their owners","volume":"52","author":"Heidenberger","year":"1997"},{"key":"ref12","series-title":"J Am Vet Med Assoc","first-page":"1602","article-title":"Signalment factors, comorbidity, and trends in behavior diagnoses in cats: 736 cases (1991\u20132001)","volume":"229","author":"Bamberger","year":"2006"},{"issue":"3","key":"ref13","series-title":"Feline Pract","first-page":"14","article-title":"Stress and the feline urological syndrome","volume":"4","author":"Caston","year":"1973"},{"key":"ref14","series-title":"The diseases of the cat and its general management","first-page":"261","article-title":"Retention of urine and urine deposits","author":"Kirk","year":"1925"},{"key":"ref15","series-title":"Eur J Pharmacol","first-page":"174","article-title":"Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators","volume":"583","author":"McEwen","year":"2008"},{"key":"ref16","series-title":"Psychoneuroendocrinology","first-page":"567","article-title":"The cognitive activation theory of stress","volume":"29","author":"Ursin","year":"2004"},{"issue":"suppl","key":"ref17","series-title":"Acta Agric Scand A Anim Sci","first-page":"22","article-title":"Animal welfare defined in terms of attempts to cope with the environment","volume":"27","author":"Broom","year":"1996"},{"key":"ref18","series-title":"Neurosci Biobehav Rev","first-page":"3","article-title":"The Darwinian concept of stress: benefits of allostasis and costs of allostatic load and the trade-offs in health and disease","volume":"29","author":"Korte","year":"2005"},{"key":"ref19","series-title":"Biol Psychiatry","first-page":"732","article-title":"Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression","volume":"65","author":"Miller","year":"2009"},{"key":"ref20","series-title":"Nat Rev Neurosci","first-page":"46","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008"},{"key":"ref21","series-title":"Mol Psychiatry","first-page":"239","article-title":"Brain-immune interactions and disease susceptibility","volume":"10","author":"Marques-Deak","year":"2005"},{"key":"ref22","series-title":"Am J Psychiatry","first-page":"1554","article-title":"When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders","volume":"160","author":"Raison","year":"2003"},{"key":"ref23","series-title":"Curr Pain Headache Rep","first-page":"98","article-title":"The relationship between cytokines and pain\/depression: a review and current status","volume":"11","author":"Strouse","year":"2007"},{"key":"ref24","series-title":"The biology of animal stress: basic principles and implications for animal welfare","first-page":"337","article-title":"Alleviating stress in zoos with environmental enrichment","author":"Carlstead","year":"2000"},{"key":"ref25","series-title":"Appl Anim Behav Sci","first-page":"143","article-title":"Behavioral and physiological correlates of stress in laboratory cats","volume":"38","author":"Carlstead","year":"1993"},{"key":"ref26","series-title":"Am J Vet Res","first-page":"203","article-title":"In vivo evaluation of \u03b12-adrenoceptors in cats with idiopathic cystitis","volume":"68","author":"Westropp","year":"2007"},{"key":"ref27","series-title":"Appl Anim Behav Sci","first-page":"262","article-title":"Sources of stress in captivity","volume":"102","author":"Morgan","year":"2007"},{"key":"ref28","series-title":"J Am Vet Med Assoc","first-page":"994","article-title":"External and internal influences on disease risk in cats","volume":"220","author":"Buffington","year":"2002"},{"key":"ref29","series-title":"Brain Behav Immun","first-page":"153","article-title":"Twenty years of research on cytokine-induced sickness behavior","volume":"21","author":"Dantzer","year":"2007"},{"key":"ref30","series-title":"Neuropsychopharmacology","first-page":"2341","article-title":"Aging exacerbates depressive-like behavior in mice in response to activation of the peripheral innate immune system","volume":"33","author":"Godbout","year":"2008"},{"key":"ref31","series-title":"Am J Ind Med","first-page":"370","article-title":"Relationship between stress and pain in work-related upper extremity disorders: the hidden role of chronic multisymptom illnesses","volume":"41","author":"Clauw","year":"2002"},{"key":"ref32","series-title":"Semin Arthritis Rheum","first-page":"339","article-title":"Central sensitivity syndromes: a new paradigm and group nosology for fibromyalgia and overlapping conditions, and the related issue of disease versus illness","volume":"37","author":"Yunus","year":"2008"},{"key":"ref33","series-title":"Physiol Rev","first-page":"873","article-title":"Physiology and neurobiology of stress and adaptation: central role of the brain","volume":"87","author":"McEwen","year":"2007"},{"key":"ref34","series-title":"J Am Vet Med Assoc","first-page":"1709","article-title":"Causes of urine marking in cats and effects of environmental management on frequency of marking","volume":"219","author":"Pryor","year":"2001"},{"key":"ref35"}],"container-title":["Journal of the American Veterinary Medical 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