{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T09:21:48Z","timestamp":1768296108976,"version":"3.49.0"},"reference-count":54,"publisher":"American Veterinary Medical Association (AVMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2011,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To evaluate the use of transcranial magnetic stimulation for differentiating between clinically relevant and clinically irrelevant cervical spinal cord compression on magnetic resonance imaging (MRI).<\/jats:p>\n<jats:p><jats:bold>Design<\/jats:bold>\u2014Validation study.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u2014Clinically normal Doberman Pinschers without (n = 11) and with (6) spinal cord compression on MRI and 16 Doberman Pinschers with disk-associated wobbler syndrome (DAWS).<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014After dogs were sedated, transcranial magnetic motor evoked potentials were recorded from the extensor carpi radialis muscle (ECRM) and cranial tibial muscle (CTM). Onset latencies and peak-to-peak amplitudes were measured. Magnetic resonance imaging was performed to identify spinal cord compression.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014There were significant differences in ECRM and CTM onset latencies between Doberman Pinschers with DAWS and each of the 2 groups of clinically normal dogs, but there were no significant differences in ECRM and CTM onset latencies between the 2 groups of clinically normal dogs. There were significant differences in CTM peak-to-peak amplitudes between Doberman Pinschers with DAWS and each of the 2 groups of clinically normal dogs, but there were no significant differences in ECRM peak-to-peak amplitudes among groups or in CTM peak-to-peak amplitudes between the 2 groups of clinically normal dogs. There was a significant correlation between severity of spinal cord compression and ECRM onset latency, CTM onset latency, and CTM peak-to-peak amplitude.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results suggested that transcranial magnetic stimulation may be a useful diagnostic tool to differentiate between clinically relevant and clinically irrelevant spinal cord compression identified on MRI alone.<\/jats:p>","DOI":"10.2460\/javma.238.1.81","type":"journal-article","created":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T08:02:51Z","timestamp":1293868971000},"page":"81-88","source":"Crossref","is-referenced-by-count":16,"title":["Transcranial magnetic stimulation in Doberman Pinschers with clinically relevant and clinically irrelevant spinal cord compression on magnetic resonance imaging"],"prefix":"10.2460","volume":"238","author":[{"given":"Steven","family":"De Decker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Van Soens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc","family":"Duchateau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid M. V. L.","family":"Gielen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henri J. J.","family":"van Bree","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique H. A. R.","family":"Binst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Waelbers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc M. L. M.","family":"Van Ham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Vet Clin North Am Small Anim Pract","first-page":"667","article-title":"Disc-associated wobbler syndrome in the Doberman Pinscher","volume":"18","author":"VanGundy","year":"1988"},{"key":"ref2","series-title":"Small animal spinal disorders. Diagnosis and surgery","first-page":"211","article-title":"Cervical spondylomyelopathy","author":"Sharp","year":"2005"},{"key":"ref3","series-title":"Vlaams Diergeneeskd Tijdschr","first-page":"139","article-title":"Diagnosis, treatment and prognosis of disc associated wobbler syndrome in dogs","volume":"78","author":"De Decker","year":"2008"},{"key":"ref4","series-title":"Vet Radiol Ultrasound","first-page":"332","article-title":"Magnetic resonance imaging of the cervical spine in 27 dogs","volume":"40","author":"Levitski","year":"1999"},{"key":"ref5","series-title":"Vet Radiol Ultrasound","first-page":"523","article-title":"Comparison of magnetic resonance imaging and myelography in 18 Doberman Pinscher dogs with cervical spondylomyelopathy","volume":"47","author":"da Costa","year":"2006"},{"key":"ref6","series-title":"Vet Rec","first-page":"11","article-title":"Detection of spinal cord compression in dogs with cervical intervertebral disc disease by magnetic resonance imaging","volume":"163","author":"Ryan","year":"2008"},{"key":"ref7","series-title":"Vet Radiol Ultrasound","first-page":"2","article-title":"Magnetic resonance imaging-a general overview of principles and examples in veterinary neurodiagnosis","volume":"34","author":"Thomson","year":"1993"},{"key":"ref8","series-title":"Radiology","first-page":"83","article-title":"Asymptomatic degenerative disk disease and spondylosis of the cervical spine: MR imaging","volume":"164","author":"Teresi","year":"1987"},{"key":"ref9","series-title":"J Bone Joint Surg Am","first-page":"1178","article-title":"Abnormal magnetic-resonance scans of the cervical spine in asymptomatic subjects. A prospective investigation","volume":"72","author":"Boden","year":"1990"},{"key":"ref10","series-title":"Neuroradiology","first-page":"49","article-title":"Age-related MRI changes at 0.1 T in cervical disks in asymptomatic subjects","volume":"36","author":"Lehto","year":"1994"},{"key":"ref11","series-title":"J Bone Joint Surg Br","first-page":"19","article-title":"MRI of cervical discs in asymptomatic subjects","volume":"80","author":"Matsumoto","year":"1998"},{"key":"ref12","series-title":"Am J Vet Res","first-page":"1601","article-title":"Morphologic and morphometric magnetic resonance imaging features of Doberman Pinschers with and without clinical signs of cervical spondylomyelopathy","volume":"67","author":"da Costa","year":"2006"},{"key":"ref13","series-title":"Am J Vet Res","first-page":"428","article-title":"Low field magnetic resonance imaging (MRI) findings of the caudal portion of the cervical region in clinically normal Doberman Pinschers and Foxhounds","volume":"71","author":"De Decker","year":"2010"},{"key":"ref14","series-title":"J Am Vet Med Assoc","first-page":"74","article-title":"Intraobserver and interobserver agreement for results of low-field magnetic resonance imaging in dogs with and without clinical signs of disk-associated wobbler syndrome","volume":"238","author":"De Decker","year":"2011"},{"key":"ref15","series-title":"Lancet","first-page":"1106","article-title":"Noninvasive magnetic stimulation of the human motor cortex","volume":"1","author":"Barker","year":"1985"},{"key":"ref16","series-title":"Clin Neurophysiol","first-page":"1297","article-title":"the diagnostic value of motor evoked potentials","volume":"110","author":"Di Lazzaro","year":"1999"},{"key":"ref17","series-title":"Neurology","first-page":"75","article-title":"Magnetic stimulation of the motor cortex in cervical spondylosis","volume":"41","author":"Maertens de Noordhout","year":"1991"},{"key":"ref18","series-title":"Acta Neurol Scand","first-page":"348","article-title":"magnetic motor evoked potentials in diseases of the spinal cord","volume":"90","author":"Linden","year":"1994"},{"key":"ref19","series-title":"Orthopedics","first-page":"1017","article-title":"Transcranial magnetic motor-evoked potentials in scoliosis surgery","volume":"18","author":"Glassman","year":"1995"},{"key":"ref20","series-title":"Dan Med Bull","first-page":"448","article-title":"The role of transcranial magnetic stimulation and motor evoked potentials in the investigation of central motor pathways in multiple sclerosis","volume":"43","author":"Ravnborg","year":"1996"},{"key":"ref21","series-title":"Arch Phys Med Rehabil","first-page":"442","article-title":"transcranial magnetic stimulation for detection of preclinical cervical spondylotic myelopathy","volume":"73","author":"Travlos","year":"1992"},{"key":"ref22","series-title":"Arch Phys Med Rehabil","first-page":"1456","article-title":"Predicting neurologic recovery in traumatic cervical spinal cord injury","volume":"79","author":"Kirshblum","year":"1998"},{"key":"ref23","series-title":"Spine","first-page":"15","article-title":"Assessment of cervical myelopathy using transcranial magnetic stimulation and prediction of prognosis after laminoplasty","volume":"33","author":"Takahashi","year":"2008"},{"key":"ref24","series-title":"Am J Vet Res","first-page":"1732","article-title":"Evoked potentials induced by transcranial stimulation in dogs","volume":"51","author":"Kraus","year":"1990"},{"key":"ref25","series-title":"Prog Vet Neurol","first-page":"321","article-title":"Motor potentials evoked by transcranial stimulation of the canine motor cortex","volume":"1","author":"Strain","year":"1990"},{"key":"ref26","series-title":"Prog Vet Neurol","first-page":"147","article-title":"Transcranial magnetic motor evoked potentials in sedated dogs","volume":"3","author":"Van Ham","year":"1994"},{"key":"ref27","series-title":"Prog Vet Neurol","first-page":"5","article-title":"Transcranial magnetic motor evoked potentials in anesthetized dogs","volume":"6","author":"Van Ham","year":"1995"},{"key":"ref28","series-title":"J Vet Intern Med","first-page":"326","article-title":"Magnetic motor evoked potentials in ponies","volume":"10","author":"Mayhew","year":"1996"},{"key":"ref29","series-title":"Equine Vet J","first-page":"51","article-title":"Transcranial magnetic stimulation: normal values of magnetic motor evoked potentials in 84 normal horses and influence of height, weight, age and sex","volume":"36","author":"Nollet","year":"2004"},{"key":"ref30","series-title":"Am J Vet Res","first-page":"142","article-title":"Comparison of two techniques of narcotic-induced anesthesia for use during recording of magnetic motor evoked potentials in dogs","volume":"57","author":"Van Ham","year":"1996"},{"key":"ref31","series-title":"Vet Rec","first-page":"534","article-title":"Influence of detomidine and buprenorphine on magnetic motor evoked potentials","volume":"152","author":"Nollet","year":"2003"},{"key":"ref32","series-title":"Vet J","first-page":"163","article-title":"Effects of sedative and hypnotic drug combinations on transcranial magnetic motor evoked potential, bispectral index and ARX-derived auditory evoked potential index in dogs","volume":"181","author":"Van Soens","year":"2009"},{"key":"ref33","series-title":"Equine Vet J","first-page":"156","article-title":"The use of magnetic motor evoked potentials in horses with cervical spinal cord disease","volume":"34","author":"Nollet","year":"2002"},{"key":"ref34","series-title":"Am J Vet Res","first-page":"1382","article-title":"Use of magnetic motor-evoked potentials in horses with bilateral hind limb ataxia","volume":"64","author":"Nollet","year":"2003"},{"key":"ref35","series-title":"Vet Surg","first-page":"5","article-title":"Magnetic motor evoked potentials for assessing spinal cord integrity in dogs with intervertebral disc disease","volume":"22","author":"Sylvestre","year":"1993"},{"key":"ref36","series-title":"J Am Vet Med Assoc","first-page":"60","article-title":"Correlation between severity of clinical signs and motor evoked potentials after transcranial magnetic stimulation in large-breed dogs with cervical spinal cord disease","volume":"221","author":"Poma","year":"2002"},{"key":"ref37","series-title":"Am J Vet Res","first-page":"1613","article-title":"Correlation of motor evoked potentials with magnetic resonance imaging and neurologic findings in Doberman Pinschers with and without signs of cervical spondylomyelopathy","volume":"67","author":"Da Costa","year":"2006"},{"key":"ref38","series-title":"Spine","first-page":"1137","article-title":"Systematic correlation of transcranial magnetic stimulation and magnetic resonance imaging in cervical spondylotic myelopathy","volume":"29","author":"Lo","year":"2004"},{"key":"ref39","series-title":"Electroencephalogr Clin Neurophysiol","first-page":"365","article-title":"Early and late lower limb motor evoked potentials elicited by transcranial magnetic motor cortex stimulation","volume":"85","author":"Dimitrijevic","year":"1992"},{"key":"ref40","series-title":"Muscle Nerve","first-page":"628","article-title":"Motor and somato-sensory evoked potentials in asymptomatic spondylotic cord compression","volume":"22","author":"Tavy","year":"1999"},{"key":"ref41","series-title":"Eur Spine J","first-page":"493","article-title":"The value of somato-sensory and motor evoked potentials in pre-clinical spondylotic cervical cord compression","volume":"7","author":"Bednarik","year":"1998"},{"key":"ref42","series-title":"Ann Acad Med Singapore","first-page":"886","article-title":"The role of electrophysiology in the diagnosis and management of cervical spondylotic myelopathy","volume":"36","author":"Lo","year":"2007"},{"key":"ref43","series-title":"Vet J","first-page":"28","article-title":"Transcranial magnetic stimulation: review of the technique, basic principles and applications","volume":"166","author":"Nollet","year":"2003"},{"key":"ref44","series-title":"Spine","first-page":"1","article-title":"Canal diameter, anteroposterior compression ratio, and spondylotic myelopathy of the cervical spine","volume":"8","author":"Ogino","year":"1983"},{"key":"ref45","series-title":"Veterinary neuroanatomy and clinical neurology","first-page":"243","article-title":"Small animal spinal cord disease","author":"de Lahunta","year":"2009"},{"key":"ref46","series-title":"Exp Brain Res","first-page":"128","article-title":"Transcranial magnetic stimulation. Which part of the current waveform causes the stimulation?","volume":"141","author":"Corthout","year":"2001"},{"key":"ref47","series-title":"Neurosurgery","first-page":"520","article-title":"Origins and conducting pathways of motor evoked potentials elicited by transcranial magnetic stimulation in cats","volume":"31","author":"Kawai","year":"1992"},{"key":"ref48","series-title":"Eur J Neurosci","first-page":"805","article-title":"Evaluation of transcranial magnetic stimulation for investigating transmission in descending motor tracts in the rat","volume":"25","author":"Nielsen","year":"2007"},{"key":"ref49","series-title":"Physiological and clinical anatomy of the domestic mammals","article-title":"Pyramidal system","volume":"1","author":"King","year":"2005"},{"key":"ref50","series-title":"Neurosurgery","first-page":"117","article-title":"Motor evoked potentials in the dog: effects of global ischemia on spinal cord and peripheral nerve signals","volume":"20","author":"Konrad","year":"1987"},{"key":"ref51","series-title":"Spine","first-page":"673","article-title":"Effects of spinal cord lesioning on somatosensory and neurogenic-motor evoked potentials","volume":"14","author":"Owen","year":"1989"},{"key":"ref52","series-title":"Vet Surg","first-page":"341","article-title":"The effects of aortic occlusion on transcranially induced evoked potentials in the dog","volume":"19","author":"Kraus","year":"1990"},{"key":"ref53","series-title":"Magnetic stimulation in clinical neurophysiology","first-page":"55","article-title":"Magnetic stimulation of the human nervous system: an introduction and basic principles","author":"Barker","year":"1989"},{"key":"ref54","series-title":"Electroencephalogr Clin Neurophysiol","first-page":"1","article-title":"Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines for the International Workshop on the safety of repetitive transcranial magnetic stimulation","volume":"108","author":"Wassermann","year":"1998"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/238\/1\/javma.238.1.81.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/238\/1\/javma.238.1.81.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/238\/1\/javma.238.1.81.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T14:02:23Z","timestamp":1741356143000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/238\/1\/javma.238.1.81.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,1]]},"references-count":54,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.2460\/javma.238.1.81","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1,1]]}}}