{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:43:12Z","timestamp":1763746992870,"version":"3.38.0"},"reference-count":13,"publisher":"American Veterinary Medical Association (AVMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2011,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Case Description<\/jats:bold>\u2014A 7-year-old 23-kg (50.6-lb) spayed female Border Collie with a history of heartworm disease was evaluated for respiratory distress.<\/jats:p>\n<jats:p><jats:bold>Clinical Findings<\/jats:bold>\u2014Computed tomography of the thorax revealed possible pulmonary bullae or blebs, and on the basis of these findings, a tentative diagnosis of bullous emphysema was made.<\/jats:p>\n<jats:p><jats:bold>Treatment and Outcome<\/jats:bold>\u2014Exploratory median sternotomy revealed gross pathological lesions in the right caudal lung lobe; the most peripheral portion appeared discolored (pale pink), and a clear line of demarcation was observed. Upon excision of the affected lung lobe, a worm segment was noticed both on the remaining stump of the lung lobe in the dog and in the removed lobe. At this time, the dog had an anaphylactoid reaction. The reaction was successfully treated with fluid therapy, antihistamines, and corticosteroids. Lung lobectomy of the right caudal lobe resulted in clinical resolution of the bilateral pneumothorax. However, during the postoperative period, the dog developed a hemothorax and was returned to surgery. As no obvious cause for the hemothorax was seen at the second surgery, the dog was treated for a potential coagulopathy with fresh frozen plasma, which provided clinical resolution of the hemothorax. Parasitological examination of the worm segment confirmed a <jats:italic>Dirofilaria immitis<\/jats:italic> infection. The dog was discharged 5 days after surgery and treated with doxycycline for 30 days and monthly administration of heartworm preventative was prescribed.<\/jats:p>\n<jats:p><jats:bold>Clinical Relevance<\/jats:bold>\u2014Heartworm infection should be a differential diagnosis in dogs with spontaneous pneumothorax. Anaphylactoid reactions associated with accidental dissection of adult heartworms should be managed with treatment aimed at cardiovascular stabilization.<\/jats:p>","DOI":"10.2460\/javma.238.10.1301","type":"journal-article","created":{"date-parts":[[2011,5,15]],"date-time":"2011-05-15T07:04:14Z","timestamp":1305443054000},"page":"1301-1304","source":"Crossref","is-referenced-by-count":10,"title":["Anaphylactoid reaction in a heartworm-infected dog undergoing lung lobectomy"],"prefix":"10.2460","volume":"238","author":[{"given":"Jennifer E.","family":"Carter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Chanoit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl","family":"Kata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"series-title":"ASA physical status classification system","key":"ref1"},{"key":"ref2","series-title":"Can Vet J","first-page":"80","article-title":"Pneumothorax in a dog with Dirofilaria immitis infection","volume":"10","author":"Fletch","year":"1969"},{"key":"ref3","series-title":"J Am Vet Med Assoc","first-page":"1893","article-title":"Pneumothorax in a dog infected with Dirofilaria immitis","volume":"201","author":"Busch","year":"1992"},{"key":"ref4","series-title":"J Am Vet Med Assoc","first-page":"91","article-title":"Pneumothorax secondary to Dirofilaria immitis infection in two cats","volume":"213","author":"Smith","year":"1998"},{"key":"ref5","series-title":"Textbook of canine and feline cardiology: principles and clinical practice","first-page":"702","article-title":"Canine heartworm disease","author":"Calvert","year":"1999"},{"key":"ref6","series-title":"Vet Parasit","first-page":"196","article-title":"Acute death in heartworm-infected cats: unraveling the puzzle","volume":"158","author":"Litster","year":"2008"},{"key":"ref7","series-title":"Am J Vet Res","first-page":"765","article-title":"Comparison of heartworm extract-induced shock and endotoxin-induced shock in dogs by determination of serum tumor necrosis factor concentrations","volume":"62","author":"Kitoh","year":"2001"},{"key":"ref8","series-title":"Am J Vet Res","first-page":"770","article-title":"Role of histamine in heartworm extract-induced shock in dogs","volume":"62","author":"Kitoh","year":"2001"},{"key":"ref9","series-title":"Compend Contin Educ Pract Vet","first-page":"157","article-title":"Anaphylaxis: pathophysiology and treatment","volume":"12","author":"Mueller","year":"1990"},{"key":"ref10","series-title":"J Allergy Clin Immunol","first-page":"227","article-title":"Anaphylaxis","volume":"75","author":"Sheffer","year":"1985"},{"key":"ref11","series-title":"Am J Vet Res","first-page":"1542","article-title":"Blood coagulopathy in dogs with shock induced by injection of heartworm extract","volume":"55","author":"Kitoh","year":"1994"},{"key":"ref12","series-title":"Am J Vet Res","first-page":"1535","article-title":"Clinical, hematologic, and biochemical findings in dogs after induction of shock by injection of heartworm extract","volume":"55","author":"Kitoh","year":"1994"},{"key":"ref13","series-title":"Anesthesiology","first-page":"362","article-title":"In vivo and in vitro studies of the inhibitory effect of propofol on human platelet aggregation","volume":"88","author":"Aoki","year":"1998"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/238\/10\/javma.238.10.1301.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/238\/10\/javma.238.10.1301.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/238\/10\/javma.238.10.1301.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T13:16:24Z","timestamp":1741353384000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/238\/10\/javma.238.10.1301.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,15]]},"references-count":13,"journal-issue":{"issue":"10"},"URL":"https:\/\/doi.org\/10.2460\/javma.238.10.1301","relation":{},"ISSN":["0003-1488"],"issn-type":[{"type":"print","value":"0003-1488"}],"subject":[],"published":{"date-parts":[[2011,5,15]]}}}