{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:31:37Z","timestamp":1787506297139,"version":"build-2736575974"},"reference-count":25,"publisher":"American Veterinary Medical Association (AVMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2011,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    \u2014To compare endogenous ACTH and \u03b1-melanocyte-stimulating hormone (\u03b1-MSH) concentrations after administration of thyrotropin-releasing hormone (TRH) and to compare ACTH concentrations after TRH administration with those following domperidone administration in healthy horses and horses with pituitary pars intermedia dysfunction (PPID).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design<\/jats:bold>\n                    \u2014Prospective case series.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Animals<\/jats:bold>\n                    \u201469 clinically normal horses and 47 horses with or suspected to have PPID.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Procedures<\/jats:bold>\n                    \u2014ACTH concentrations were measured during 108 TRH stimulation tests in 88 horses, and \u03b1-MSH concentrations were measured during 56 TRH stimulation tests in 50 horses. In 28 of these horses, ACTH concentrations after domperidone administration were measured and test results were compared. The pituitary gland was histologically examined in all horses that were euthanatized.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    \u2014ACTH and \u03b1-MSH concentrations increased in all horses afterTRH administration, with a greater and more prolonged increase in horses with PPID. Percentage increase was significantly greater for \u03b1-MSH concentration than for ACTH concentration. The change in ACTH concentration after domperidone administration was less consistent in differentiating clinically normal horses from those with PPID than was the response to TRH.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\n                    \u2014Results suggested that ACTH concentration in response to TRH administration was useful for the diagnosis of PPID in horses and appeared more accurate than response to domperidone administration. Use of an \u03b1-MSH concentration \u2265 30 or 50 pmol\/L did not appear superior to use of an ACTH concentration \u2265 36 pg\/mL for the diagnosis of PPID, either before or 30 minutes after TRH administration.\n                  <\/jats:p>","DOI":"10.2460\/javma.238.10.1305","type":"journal-article","created":{"date-parts":[[2011,5,15]],"date-time":"2011-05-15T03:04:14Z","timestamp":1305428654000},"page":"1305-1315","source":"Crossref","is-referenced-by-count":43,"title":["\u03b1-Melanocyte\u2014stimulating hormone and adrenocorticotropin concentrations in response to thyrotropin-releasing hormone and comparison with adrenocorticotropin concentration after domperidone administration in healthy horses and horses with pituitary pars intermedia dysfunction"],"prefix":"10.2460","volume":"238","author":[{"given":"Jill","family":"Beech","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianne","family":"McFarlane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Lindborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice E.","family":"Sojka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond C.","family":"Boston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"J Am Vet Med Assoc","first-page":"715","article-title":"Evaluation of plasma ACTH, \u03b1-melanocyte-stimulating hormone, and insulin concentrations in clinically normal horses and ponies and those with pituitary pars intermedia 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ovariectomized and intact mares","volume":"38","author":"Guillaume","year":"2003"}],"container-title":["Journal of the American Veterinary Medical 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