{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T20:42:49Z","timestamp":1779914569396,"version":"3.53.1"},"reference-count":10,"publisher":"American Veterinary Medical Association (AVMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2011,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Case Descriptions<\/jats:bold>\u2014A 4-year-old spayed female Golden Retriever (dog 1) was examined because of acute edema and erythema in the left hind limb and an inguinal mass, and a 5-year-old female Jack Russell Terrier (dog 2) was examined because of a recurring retro-peritoneal mass.<\/jats:p>\n<jats:p><jats:bold>Clinical Findings<\/jats:bold>\u2014Dog 1 had an edematous, hyperemic left hind limb with a fixed inguinal mass. Monocytic neutrophilic leukocytosis and hypoalbuminemia were detected. Diagnostic imaging revealed abnormal tissue surrounding the larger vessels and ureters and complete occlusion of the left limb veins. Surgery resulted in incomplete removal of the mass. Histologic examination revealed fibrosing pyogranulomatous inflammation. Results of a <jats:italic>Histoplasma<\/jats:italic> antigen test were positive, and reanalysis of the tissues revealed yeast cells indicative of <jats:italic>Histoplasma capsulatum.<\/jats:italic> Dog 2 had incomplete removal of a retroperitoneal mass. Histologic examination revealed fibrosing pyogranulomatous inflammation. The mass recurred 8 months later in dog 2; exploratory abdominal surgery at that time resulted in substantial hemorrhage from the adhered caudal aorta. Histologic examination of tissue sections from the second surgery revealed yeast cells consistent with <jats:italic>Blastomyces dermatitidis.<\/jats:italic><\/jats:p>\n<jats:p><jats:bold>Treatment and Outcome<\/jats:bold>\u2014Both dogs had temporary improvement after surgery. Full clinical resolution required treatment for fungal disease. Dog 1 was treated with itraconazole, then fluconazole (total treatment time, 23 weeks). Dog 2 was treated with fluconazole for 36 weeks.<\/jats:p>\n<jats:p><jats:bold>Clinical Relevance<\/jats:bold>\u2014Retroperitoneal pyogranulomatous fibrosis caused by fungal infections has not been reported in veterinary medicine. There was substantial morbidity, but the prognosis can be good when this abnormality is recognized and antifungal medications are administered.<\/jats:p>","DOI":"10.2460\/javma.238.2.213","type":"journal-article","created":{"date-parts":[[2011,1,15]],"date-time":"2011-01-15T08:02:38Z","timestamp":1295078558000},"page":"213-219","source":"Crossref","is-referenced-by-count":6,"title":["Retroperitoneal pyogranulomatous and fibrosing inflammation secondary to fungal infections in two dogs"],"prefix":"10.2460","volume":"238","author":[{"given":"Jessica M.","family":"Clemans","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krysta L.","family":"Deitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Riedesel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Yaeger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred M.","family":"Legendre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Int J Radiat Oncol Biol Phys","first-page":"781","article-title":"Late effects of intra-operative radiation therapy on retroperitoneal tissues, intestine, and bile duct in a large animal model","volume":"29","author":"Sindelar","year":"1994"},{"key":"ref2","series-title":"Eur J Radiol","first-page":"209","article-title":"Fibrosing mediastinitis and thrombosis of superior vena cava associated with Beh\u00e7et's disease","volume":"48","author":"Harman","year":"2003"},{"key":"ref3","series-title":"Lancet","first-page":"241","article-title":"Retroperitoneal fibrosis","volume":"367","author":"Vaglio","year":"2006"},{"key":"ref4","series-title":"AJR Am J Roentgenol","first-page":"423","article-title":"Retroperitoneal fibrosis: a review of clinical features and imaging findings","volume":"191","author":"Cronin","year":"2008"},{"key":"ref5","series-title":"Infectious diseases of the dog and cat","first-page":"577","article-title":"Histoplasmosis","author":"Greene","year":"2006"},{"key":"ref6","series-title":"Infectious diseases of the dog and cat","first-page":"569","article-title":"Blastomycosis","author":"Legendre","year":"2006"},{"key":"ref7","series-title":"J Am Vet Med Assoc","first-page":"658","article-title":"Blastomycosis in dogs: 115 cases (1980\u20131995)","volume":"213","author":"Arceneaux","year":"1998"},{"key":"ref8","series-title":"J Am Vet Med Assoc","first-page":"1163","article-title":"Canine blastomycosis: a review of 47 clinical cases","volume":"178","author":"Legendre","year":"1981"},{"key":"ref9","series-title":"J Am Vet Med Assoc","first-page":"1623","article-title":"Diagnostic peritoneal lavage for identification of blastomycosis in a dog with peritoneal involvement","volume":"223","author":"Nielsen","year":"2003"},{"key":"ref10","series-title":"J Am Anim Hosp Assoc","first-page":"159","article-title":"Blastomycosis granuloma involving the cranial vena cava associated with chylothorax and cranial vena caval syndrome in a dog","volume":"36","author":"Howard","year":"2000"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/238\/2\/javma.238.2.213.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/238\/2\/javma.238.2.213.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/238\/2\/javma.238.2.213.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T14:01:51Z","timestamp":1741356111000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/238\/2\/javma.238.2.213.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,15]]},"references-count":10,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.2460\/javma.238.2.213","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1,15]]}}}