{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:22:29Z","timestamp":1770218549170,"version":"3.49.0"},"reference-count":14,"publisher":"American Veterinary Medical Association (AVMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2011,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Case Description<\/jats:bold>\u2014A 4.5-year-old spayed female domestic shorthair cat was evaluated because of a generalized seizure disorder that developed after an anesthesia-related hypoxic event.<\/jats:p>\n<jats:p><jats:bold>Clinical Findings<\/jats:bold>\u2014Following administration of phenobarbital, the seizures stopped but the cat developed severe generalized lymphadenopathy. Results of a CBC and serum biochemical analysis were unremarkable. Cytologic examination of the lymph nodes revealed a reactive lymphocyte population. Differential diagnoses included neoplasia and infection, but results of related diagnostic tests were all negative.<\/jats:p>\n<jats:p><jats:bold>Treatment and Outcome<\/jats:bold>\u2014Treatment was changed from phenobarbital to levetiracetam. Ten days following discontinuation of phenobarbital, the lymph node enlargement resolved, and the cat remained free of seizures with levetiracetam as treatment.<\/jats:p>\n<jats:p><jats:bold>Clinical Relevance<\/jats:bold>\u2014Pseudolymphoma and anticonvulsant hypersensitivity syndrome are recognized potential sequelae to anticonvulsant administration in humans. However, a pseudolymphoma-like reaction to anticonvulsants in veterinary species has not previously been reported. This case highlighted a potentially serious yet reversible sequela to phenobarbital treatment that may have been mistaken for more severe illness such as neoplasia.<\/jats:p>","DOI":"10.2460\/javma.238.3.353","type":"journal-article","created":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T08:11:20Z","timestamp":1296547880000},"page":"353-355","source":"Crossref","is-referenced-by-count":17,"title":["Suspected phenobarbital-induced pseudolymphoma in a cat"],"prefix":"10.2460","volume":"238","author":[{"given":"Meg J.","family":"Baho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Hostutler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Fenner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Corn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Arch Pediatr","first-page":"373","article-title":"Treatment of chorea with phenyl-ethyl-hydantoin; 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