{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:49:47Z","timestamp":1791294587803,"version":"4.1.0"},"reference-count":7,"publisher":"American Veterinary Medical Association (AVMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2011,7,1]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:bold>\n \u2014To evaluate and compare the outcomes of dogs with periarticular histiocytic sarcoma (PAHS) and histiocytic sarcoma of other anatomic locations (non-PAHS) and identify factors associated with outcome for dogs with PAHS.\n <\/jats:p>\n \n Design<\/jats:bold>\n \u2014Retrospective cohort study.\n <\/jats:p>\n \n Animals<\/jats:bold>\n \u201419 dogs with PAHS and 31 dogs with non-PAHS.\n <\/jats:p>\n \n Procedures<\/jats:bold>\n \u2014Medical records of dogs with histiocytic sarcoma that underwent definitive local treatment (surgery or radiation), chemotherapy, or a combination of these were reviewed. Patient signalment, clinical signs, staging test results, clinicopathologic data, type of treatment, response, and outcome were collected, and potential risk factors in dogs with PAHS were identified and analyzed for an association with outcome.\n <\/jats:p>\n \n Results<\/jats:bold>\n \u2014Dogs with PAHS lived significantly longer than did dogs with non-PAHS, with an overall median survival times of 391 (range, 48 to 980) and 128 (range, 14 to 918) days, respectively, despite the presence of suspected metastasis at diagnosis in 13 of 19 dogs with PAHS. Dogs with PAHS without evidence of metastasis at diagnosis lived significantly longer than did dogs with PAHS with evidence of metastasis, with median survival times of 980 (range, 83 to 980) and 253 (range, 48 to 441) days, respectively. Administration of prednisone in dogs with PAHS was associated with a significantly shorter time to tumor progression (TTP) and increased risk of tumor progression and death.\n <\/jats:p>\n \n Conclusions and Clinical Relevance<\/jats:bold>\n \u2014Results indicated that dogs with PAHS may have a favorable outcome independent of metastatic status when treated with chemotherapy or aggressive multimodal treatment. The concurrent administration of prednisone may be a negative predictive factor for survival time and TTP in dogs with PAHS.\n <\/jats:p>","DOI":"10.2460\/javma.239.1.90","type":"journal-article","created":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T03:04:07Z","timestamp":1309489447000},"page":"90-96","source":"Crossref","is-referenced-by-count":71,"title":["Evaluation and comparison of outcomes in dogs with periarticular and nonperiarticular histiocytic sarcoma"],"prefix":"10.2460","volume":"239","author":[{"given":"Shawna L.","family":"Klahn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara E.","family":"Kitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos G.","family":"Dervisis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Vet Pathol","first-page":"632","article-title":"Canine hemophagocytic histiocytic sarcoma: a proliferative disorder of CD11d+ macrophages","volume":"43","author":"Moore","year":"2006"},{"key":"ref2","series-title":"Vet Pathol","first-page":"74","article-title":"Localized and disseminated histiocytic sarcoma of dendritic cell origin in dogs","volume":"39","author":"Affolter","year":"2002"},{"key":"ref3","series-title":"Vet pathol","first-page":"66","article-title":"The diagnosis and prognosis of synovial tumors in dogs: 35 cases","volume":"39","author":"Craig","year":"2002"},{"key":"ref4","series-title":"Vet Comp Oncol","first-page":"63","article-title":"Histiocytic sarcomas in Flat-Coated Retrievers: a summary of 37 cases (November 1998\u2013March 2005)","volume":"4","author":"Fidel","year":"2006"},{"key":"ref5","series-title":"Vet Radiol Ultrasound","first-page":"539","article-title":"Skeletal lesions of histiocytic sarcoma in nineteen dogs","volume":"48","author":"Schultz","year":"2007"},{"key":"ref6","series-title":"Vet Comp Oncol","first-page":"139","article-title":"Long-term survival in dogs with localized histiocytic sarcoma treated with CCNU as an adjuvant to local therapy","volume":"7","author":"Skorupski","year":"2009"},{"key":"ref7","series-title":"J Vet Intern Med","first-page":"121","article-title":"CCNU for the treatment of dogs with histiocytic sarcoma","volume":"21","author":"Skorupski","year":"2007"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/239\/1\/javma.239.1.90.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/239\/1\/javma.239.1.90.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/239\/1\/javma.239.1.90.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T08:15:12Z","timestamp":1741335312000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/239\/1\/javma.239.1.90.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,1]]},"references-count":7,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.2460\/javma.239.1.90","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7,1]]}}}