{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T10:53:49Z","timestamp":1793444029937,"version":"4.5.0"},"reference-count":41,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2011,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To evaluate signalment, clinical signs, dose ingested, treatment requirements, duration of hospitalization, and outcome of dogs exposed to phenylpropanolamine.<\/jats:p>\n<jats:p><jats:bold>Design<\/jats:bold>\u2014Retrospective case series.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u2014170 dogs with potential PPA toxicosis evaluated between 2004 and 2009.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Dogs with potential PPA toxicosis were identified by reviewing the electronic database of an animal poison control center.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u201466 of the 170 (39%) dogs reportedly did not develop any clinical signs. Clinical signs reported in the remaining 104 (61%) dogs included agitation (n = 40), vomiting (27), mydriasis (19), lethargy (17), tremor or twitching (16), panting (15), bradycardia (13), tachycardia (12), hypertension (11), and erythema (8). Median dose ingested for all dogs was 29 mg\/kg (13.2 mg\/lb). Dogs developing clinical signs had a significantly higher median dose ingested (373 mg\/kg [170 mg\/lb]) than did dogs that did not develop clinical signs (18 mg\/kg [8.2 mg\/lb]). Likewise, median dose ingested for the 123 dogs treated as inpatients (36.9 mg\/kg [16.8 mg\/lb]) was significantly higher than the median dose for the 14 dogs treated as outpatients (20.5 mg\/kg [9.3 mg\/lb]). Median duration of hospitalization was 18 hours (range, 4 to 72 hours), and hospitalization time increased as the dose ingested increased. Survival rate was 99.4% (169\/170); the dog that died had ingested a dose of 145 mg\/kg (65.9 mg\/lb).<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results suggested that with supportive care, the prognosis for dogs that had ingested an overdose of phenylpropanolamine was excellent.<\/jats:p>","DOI":"10.2460\/javma.239.11.1463","type":"journal-article","created":{"date-parts":[[2011,11,17]],"date-time":"2011-11-17T08:45:57Z","timestamp":1321519557000},"page":"1463-1469","source":"Crossref","is-referenced-by-count":8,"title":["Phenylpropanolamine toxicosis in dogs: 170 cases (2004\u20132009)"],"prefix":"10.2460","volume":"239","author":[{"given":"Katherine L.","family":"Peterson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine A.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn R.","family":"Hovda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Pharmacol Ther","first-page":"363","article-title":"The vascular effects of trace amines and amphetamines","volume":"125","author":"Broadley","year":"2010"},{"key":"ref2","series-title":"J Am Anim Hosp Assoc","first-page":"413","article-title":"Cardiac toxicity from phenylpropanolamine overdose in a dog","volume":"41","author":"Crandell","year":"2005"},{"key":"ref3","series-title":"Plumb's veterinary drug handbook","author":"Plumb","year":"2008"},{"key":"ref4","series-title":"Vet Rec","first-page":"373","article-title":"Treatment of urethral sphincter mechanism incompetence in 11 bitches with a sustained-release formulation of phenylpropanolamine hydrochloride","volume":"151","author":"Bacon","year":"2002"},{"key":"ref5","series-title":"J Vet Intern Med","first-page":"47","article-title":"Effect of phenylpropanolamine and pseudoephedrine on the urethral pressure profile and continence scores of incontinent female dogs","volume":"21","author":"Byron","year":"2007"},{"key":"ref6","series-title":"J Am Vet Med Assoc","first-page":"605","article-title":"Clinical response and urethral pressure profile changes after phenylpropanolamine in dogs with primary sphincter incompetence","volume":"187","author":"Richter","year":"1985"},{"key":"ref7","series-title":"J Small Anim Pract","first-page":"493","article-title":"Evaluation of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch","volume":"43","author":"Scott","year":"2002"},{"key":"ref8","series-title":"Vet Rec","first-page":"478","article-title":"Phenylpropanolamine: an \u03b1-adrenergic agent for the management of urinary incontinence in the bitch associated with urethral sphincter mechanism incompetence","volume":"125","author":"White","year":"1989"},{"key":"ref9","series-title":"Am J Clin Nutr","first-page":"206S","article-title":"Phenylpropanolamine and blood pressure: a review of prospective studies","volume":"55","author":"Morgan","year":"1992"},{"key":"ref10","series-title":"Clin Pharmacol Ther","first-page":"488","article-title":"Propranolol antagonism of phenylpropanolamine induced hypertension","volume":"37","author":"Pentel","year":"1985"},{"key":"ref11","series-title":"J Hum Hypertens","first-page":"643","article-title":"The impact of oral phenylpropanolamine on blood pressure: a meta-analysis and review of the literature","volume":"19","author":"Salerno","year":"2005"},{"key":"ref12","series-title":"JAMA","first-page":"3267","article-title":"al. Determinants of the pressor effect of phenylpropanolamine in healthy subjects","volume":"261","author":"Blackburn","year":"1989"},{"key":"ref13","series-title":"Am J Med","first-page":"427","article-title":"Transient hypertension after two phenylpropanolamine diet aids and the effects of caffeine: a placebo-controlled follow-up study","volume":"86","author":"Lake","year":"1989"},{"key":"ref14","series-title":"Am J Med","first-page":"339","article-title":"A double dose of phenylpropanolamine causes transient hypertension","volume":"85","author":"Lake","year":"1988"},{"key":"ref15","series-title":"Ann Emerg Med","first-page":"359","article-title":"Phenylpropanolamine and associated myocardial injury","volume":"28","author":"Leo","year":"1996"},{"key":"ref16","series-title":"J Emerg Med","first-page":"55","article-title":"Myocardial infarction associated with phenylpropanolamine","volume":"18","author":"Oosterbaan","year":"2000"},{"key":"ref17","series-title":"Pediatr Emerg Care","first-page":"173","article-title":"Supraventricular tachycardia following administration of phenylpropanolamine in an infant","volume":"5","author":"Conway","year":"1989"},{"key":"ref18","series-title":"Br Heart J","first-page":"51","article-title":"Myocardial injury after phenylpropanolamine ingestion","volume":"47","author":"Pentel","year":"1982"},{"key":"ref19","series-title":"JAMA","first-page":"2646","article-title":"Atrioventricular conduction block caused by phenylpropanolamine (lett)","volume":"253","author":"Woo","year":"1985"},{"key":"ref20","series-title":"Southern Med J","first-page":"1548","article-title":"Acute renal failure due to phenylpropanolamine","volume":"74","author":"Duffy","year":"1981"},{"key":"ref21","series-title":"Stroke","first-page":"119","article-title":"Cerebral hemorrhage associated with phenylpropanolamine in combination with caffeine","volume":"15","author":"Mueller","year":"1984"},{"key":"ref22","series-title":"Stroke","first-page":"510","article-title":"Intracranial hemorrhages due to phenylpropanolamine","volume":"16","author":"Kikta","year":"1985"},{"key":"ref23","series-title":"N Engl J Med","first-page":"1826","article-title":"Phenylpropanolamine and the risk of hemorrhagic stroke","volume":"343","author":"Kernan","year":"2000"},{"key":"ref24","series-title":"Stroke","first-page":"1667","article-title":"Stroke associated with sympathomimetics contained in over-the-counter cough and cold drugs","volume":"34","author":"Cantu","year":"2003"},{"key":"ref25","series-title":"JAMA","first-page":"601","article-title":"Amphetamine-like reactions to phenylpropanolamine","volume":"245","author":"Dietz","year":"1981"},{"key":"ref26","series-title":"Am J Med","first-page":"195","article-title":"Adverse drug effects attributed to phenylpropanolamine: a review of 142 case reports","volume":"89","author":"Lake","year":"1990"},{"key":"ref27","series-title":"Pediatrics","first-page":"1","article-title":"Toxicity of over-the-counter cough and cold medications","volume":"108","author":"Gunn","year":"2001"},{"key":"ref28","series-title":"Physiology","first-page":"40","article-title":"Autonomic nervous system","author":"Costanzo","year":"2002"},{"key":"ref29","series-title":"J Vet Emerg Crit Care","first-page":"2","article-title":"An update on cardiovascular adrenergic receptor physiology and potential pharmacological applications in veterinary critical care","volume":"18","author":"Long","year":"2008"},{"key":"ref30","series-title":"Biopharm Drug Dispos","first-page":"497","article-title":"Phenylpropanolamine pharmacokinetics in dogs after intravenous, oral, and oral controlled-release doses","volume":"5","author":"Hussain","year":"1987"},{"key":"ref31","series-title":"Vet J","first-page":"201","article-title":"Combined pharmacokinetics and urodynamic study of the effects of oral administration of phenylpropanolamine in female Beagle dogs","volume":"184","author":"Noel","year":"2010"},{"key":"ref32","series-title":"Textbook of veterinary internal medicine","first-page":"1539","article-title":"Early spay and neuter","author":"Root Kustritz","year":"2000"},{"key":"ref33","series-title":"Kirk's current veterinary therapy XIII small animal practice","first-page":"896","article-title":"Urethral sphincter mechanism incompetence in male dogs","author":"Arnold","year":"2000"},{"key":"ref34","series-title":"Kirk's current veterinary therapy XI small animal practice","first-page":"875","article-title":"Relationship of urinary incontinence to neutering","author":"Arnold","year":"1992"},{"key":"ref35","series-title":"Kirk's current veterinary therapy XIV small animal practice","first-page":"92","article-title":"Toxic exposure in small animals","author":"Hovda","year":"2009"},{"key":"ref36","series-title":"Br Vet J","first-page":"135","article-title":"Developments in the understanding of the pathophysiology of urethral sphincter mechanism incompetence in the bitch","volume":"150","author":"Gregory","year":"1994"},{"key":"ref37","series-title":"Arch Int Pharmacodyn Ther","first-page":"13","article-title":"Cardiovascular studies of phenylpropanolamine","volume":"327","author":"Vick","year":"1994"},{"key":"ref38","series-title":"Fundam Appl Toxicol","first-page":"167","article-title":"Myocardial necrosis due to intraperitoneal administration of phenylpropanolamine in rats","volume":"9","author":"Pentel","year":"1987"},{"key":"ref39","series-title":"Small animal critical care medicine","first-page":"176","article-title":"Hypertensive crisis","author":"Brown","year":"2009"},{"key":"ref40","series-title":"Small animal toxicology","first-page":"127","article-title":"Toxological decontamination","author":"Peterson","year":"2006"},{"key":"ref41","series-title":"Small animal toxicology","first-page":"273","article-title":"Recreational drugs","author":"Volmer","year":"2006"}],"container-title":["Journal of the American Veterinary Medical 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