{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:22:58Z","timestamp":1780492978229,"version":"3.54.1"},"reference-count":40,"publisher":"American Veterinary Medical Association (AVMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2011,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To define clinical differences between coagulase-positive and coagulase-negative <jats:italic>Staphylococcus schleiferi<\/jats:italic> infections in dogs and to identify risk factors for the isolation of oxacillin-resistant <jats:italic>S schleiferi<\/jats:italic>.<\/jats:p>\n<jats:p><jats:bold>Design<\/jats:bold>\u2014Retrospective case series.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u2014225 dogs (yielding 225 <jats:italic>S schleiferi<\/jats:italic> isolates).<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Information obtained from affected dogs' medical records included isolate body site source, antimicrobial treatments, and primary disease. For each dog, the <jats:italic>S schleiferi<\/jats:italic> isolate was characterized and antimicrobial susceptibility data were recorded. Risk factors for infection based on coagulase status and for <jats:italic>S schleiferi<\/jats:italic> oxacillin resistance were investigated.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014Allergic dermatitis was the most common underlying disease (111\/225 dogs). Ears (102 [45%]) and skin (95 [42%]) were sources of most of the 225 isolates. Isolate coagulase status was not significantly associated with any patient-level factors. Of the 225 isolates, 129 (57%) were oxacillin resistant. Coagulase-negative isolates were more likely to be oxacillin resistant than were coagulase-positive isolates (odds ratio [OR], 1.8; 95% confidence interval [CI], 1.1 to 3.0). Administration of penicillin-based or first-generation cephalosporin drugs (OR, 3.0; 95% CI, 1.8 to 5.9) and third-generation cephalosporins (OR, 3.7; 95% CI, 1.1 to 12.3) within 30 days prior to culture were risk factors for oxacillin resistance.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results suggested that coagulase-negative and coagulase-positive <jats:italic>S schleiferi are<\/jats:italic> potential pathogens in dogs and are often oxacillin resistant. Recent patient treatments with penicillin or cephalosporin were risk factors for oxacillin resistance. In clinical cases, full speciation of all <jats:italic>Staphylococcus<\/jats:italic> isolates should be performed and microbial treatments should be selected on the basis of results of susceptibility testing.<\/jats:p>","DOI":"10.2460\/javma.239.12.1566","type":"journal-article","created":{"date-parts":[[2011,12,2]],"date-time":"2011-12-02T08:33:38Z","timestamp":1322814818000},"page":"1566-1573","source":"Crossref","is-referenced-by-count":53,"title":["Clinical characterization of Staphylococcus schleiferi infections and identification of risk factors for acquisition of oxacillin-resistant strains in dogs: 225 cases (2003\u20132009)"],"prefix":"10.2460","volume":"239","author":[{"given":"Christine L.","family":"Cain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel O.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley C.","family":"Rankin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Int J Syst Bacteriol","first-page":"168","article-title":"Staphylococcus lugdunesis sp. nov. and Staphylococcus schleiferi sp. nov., two species from human clinical samples","volume":"38","author":"Freney","year":"1988"},{"key":"ref2","series-title":"Int J Syst Bacteriol","first-page":"409","article-title":"Staphylococcus schleiferi subsp. coagulans subsp. nov., isolated from the external auditory meatus of dogs with external ear otitis","volume":"40","author":"Igimi","year":"1990"},{"key":"ref3","series-title":"Infect Immun","first-page":"4272","article-title":"Staphylococcus schleiferi subsp. schleiferi expresses a fibronectin-binding protein","volume":"67","author":"Peacock","year":"1999"},{"key":"ref4","series-title":"J Clin Microbiol","first-page":"3887","article-title":"Osteomyelitis caused by Staphylococcus 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