{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:58:13Z","timestamp":1791863893357,"version":"4.3.4"},"reference-count":33,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2011,9,1]]},"abstract":"Abstract<\/jats:title>\nCase Description<\/jats:bold>\u2014A 0.65-kg (1.43-lb) 24-month-old sexually intact male albino pet rat was examined because of a 3-week history of hypodipsia, apparent blindness, and sudden change in behavior.<\/jats:p>\nClinical Findings<\/jats:bold>\u2014The rat was able to move around its cage but appeared unaware of its surroundings, was visually unresponsive, and seemed unusually aggressive. The rat's hind limbs appeared mildly paretic, and it had sporadic difficulty placing its hind limbs on a flat surface. Given the rat's age, history, and physical examination findings, the primary differential diagnosis was a pituitary tumor. Magnetic resonance imaging (MRI) of the rat's brain was performed and revealed a large pituitary mass, which was indicative of a tumor.<\/jats:p>\nTreatment and Outcome<\/jats:bold>\u2014Cabergoline (0.6 mg\/kg [0.27 mg\/lb], PO, q 72 h) was administered. On follow-up MRI 2 months later, the pituitary mass had substantially decreased in size. For 6 months following the second MRI study, the rat continued to receive the same dosage of cabergoline and had no clinical signs of disease or unusual behavior. However, at 8.5 months after the start of the treatment, the rat was in poor condition and had clinical signs similar to those initially. A third MRI study was performed and revealed substantial regrowth of the mass. The rat was euthanized and a necropsy was performed; a histopathologic diagnosis of pituitary adenoma was made.<\/jats:p>\nClinical Relevance<\/jats:bold>\u2014Pituitary adenomas have long been recognized as a common finding in geriatric rats (> 18 months old). Affected rats may respond favorably to oral administration of cabergoline.<\/jats:p>","DOI":"10.2460\/javma.239.5.656","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T17:48:35Z","timestamp":1314899315000},"page":"656-660","source":"Crossref","is-referenced-by-count":23,"title":["Extralabel use of cabergoline in the treatment of a pituitary adenoma in a rat"],"prefix":"10.2460","volume":"239","author":[{"given":"J\u00f6rg","family":"Mayer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Kiupel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"DeCubellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Donnelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"J Gerontol","first-page":"258","article-title":"Pathological changes during aging in barrier-reared Fischer 344 male rats","volume":"32","author":"Coleman","year":"1977"},{"key":"ref2","series-title":"J Natl Cancer Inst","first-page":"1449","article-title":"Incidence of spontaneous neoplasms in F344 rats throughout the natural life-span","volume":"54","author":"Sass","year":"1975"},{"key":"ref3","series-title":"J Gerontol","first-page":"259","article-title":"Histopathological profile of a Wistar rat stock including a survey of the literature","volume":"36","author":"Kroes","year":"1981"},{"key":"ref4","series-title":"J Submicrosc Cytol","first-page":"517","article-title":"Pituitary gonadotroph adenomas in old Sprague-Dawley rats","volume":"17","author":"McComb","year":"1985"},{"key":"ref5","series-title":"J Cancer Res Clin Oncol","first-page":"187","article-title":"Spontaneous endocrine tumors in Sprague-Dawley rats","volume":"95","author":"Suzuki","year":"1979"},{"key":"ref6","series-title":"Vet Clin North Am Exot Anim Pract","first-page":"673","article-title":"Clinical presentation of pituitary adenomas in rats","volume":"9","author":"Vannevel","year":"2006"},{"key":"ref7","series-title":"Pathology of geriatric rats: a morphological and experimental study of the age-associated lesions in aging BN\/Bi, WAG\/Rij, and (WAG \u00d7 BN)F b1 s rats","author":"Burek","year":"1978"},{"key":"ref8","series-title":"Neuroendocrinology","first-page":"201","article-title":"Spontaneous sparsely-granulated prolactin-producing pituitary adenomas in geriatric rats. 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of cabergoline and bromocriptine on prolactin levels in hyperprolactinemic patients","volume":"40","author":"Sabuncu","year":"2001"},{"key":"ref33","series-title":"Endocr Rev","first-page":"485","article-title":"Advances in the treatment of prolactinomas","volume":"27","author":"Gillam","year":"2006"}],"container-title":["Journal of the American Veterinary Medical 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