{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T21:25:17Z","timestamp":1773696317844,"version":"3.50.1"},"reference-count":11,"publisher":"American Veterinary Medical Association (AVMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2011,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Case Description<\/jats:bold>\u2014A 4-year-old spayed female Boxer was evaluated for a cutaneous mass located on the dorsum. The mass had been present for 6 weeks and was increasing in size.<\/jats:p>\n<jats:p><jats:bold>Clinical Findings<\/jats:bold>\u2014A mass of approximately 10 cm in diameter was detected on the dorsum cranial to the right ilial wing. Histologic examination of a tissue sample from the mass led to the diagnosis of cutaneous pythiosis. Computed tomography of the abdomen and the mass were performed and revealed a contrast-enhancing soft tissue mass of the dorsum and enlarged intra-abdominal lymph nodes.<\/jats:p>\n<jats:p><jats:bold>Treatment and Outcome<\/jats:bold>\u2014The dog underwent surgical excision of the cutaneous mass, including 5-cm skin margins and deep margins of 2 fascial planes. The mass was completely excised on the basis of results of histologic examination of surgical margins. The dog received itraconazole and terbinafine by mouth for 3 months following surgery. Recheck examination at 20 months postoperatively showed no signs of recurrence of pythiosis at the surgical site.<\/jats:p>\n<jats:p><jats:bold>Clinical Relevance<\/jats:bold>\u2014Aggressive surgical excision in combination with medical treatment resulted in a favorable long-term (&gt; 1 year) outcome in this dog. Thorough workup including diagnostic imaging and lymph node evaluation is recommended. If surgery is to be performed, skin margins of 5 cm and deep margins of 2 fascial planes are recommended.<\/jats:p>","DOI":"10.2460\/javma.239.9.1232","type":"journal-article","created":{"date-parts":[[2011,10,14]],"date-time":"2011-10-14T16:31:07Z","timestamp":1318609867000},"page":"1232-1235","source":"Crossref","is-referenced-by-count":10,"title":["Diagnosis and treatment of truncal cutaneous pythiosis in a dog"],"prefix":"10.2460","volume":"239","author":[{"given":"Kelley M.","family":"Thieman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin A.","family":"Kirkby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Flynn-Lurie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy M.","family":"Grooters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas J.","family":"Bacon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"J Vet Intern Med","first-page":"142","article-title":"Development and evaluation of an enzyme-linked immunosorbent assay for the serodiagnosis of pythiosis in dogs","volume":"16","author":"Grooters","year":"2002"},{"key":"ref2","series-title":"J Vet Intern Med","first-page":"147","article-title":"Development of a nested polymerase chain reaction assay for the detection and identification of Pythium insidiosum","volume":"16","author":"Grooters","year":"2002"},{"key":"ref3","series-title":"Med Mycol","first-page":"427","article-title":"A description of cutaneous-subcutaneous pythiosis in fifteen dogs","volume":"37","author":"Dykstra","year":"1999"},{"key":"ref4","series-title":"Vet Dermatol","first-page":"202","article-title":"Cutaneous pythiosis in a dog from Brazil","volume":"21","author":"Neto","year":"2010"},{"key":"ref5","series-title":"J Am Anim Hosp Assoc","first-page":"959","article-title":"A report of subcutaneous pythiosis in five dogs and a review of the etiologic agent Pythium spp","volume":"30","author":"Foil","year":"1984"},{"key":"ref6","series-title":"Vet Clin North Am Small Anim Pract","first-page":"695","article-title":"Pythiosis, lagenidiosis, and zygomycosis in small animals","volume":"33","author":"Grooters","year":"2003"},{"key":"ref7","series-title":"J Clin Microbiol","first-page":"2967","article-title":"Life cycle of the human and animal oomycete pathogen Pythium insidiosum","volume":"31","author":"Mendoza","year":"1993"},{"key":"ref8","series-title":"J Am Vet Med Assoc","first-page":"1821","article-title":"The current understanding and management of vaccine-associated sarcomas in cats","volume":"226","year":"2005"},{"key":"ref9","series-title":"Semin Arthritis Rheum","first-page":"204","article-title":"Human pythiosis, a rare cause of arteritis: case report and literature review","volume":"33","author":"Prasertwitayakij","year":"2003"},{"key":"ref10","series-title":"Clin Infect Dis","first-page":"1388","article-title":"Successful medical therapy for deeply invasive facial infection due to Pythium insidiosum in a child","volume":"27","author":"Shenep","year":"1998"},{"key":"ref11","series-title":"Burns","first-page":"e68","article-title":"Systemic Pythium insidiosum in a pediatric burn patient","volume":"36","author":"Franco","year":"2010"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/239\/9\/javma.239.9.1232.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/239\/9\/javma.239.9.1232.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/239\/9\/javma.239.9.1232.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T13:48:03Z","timestamp":1741355283000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/239\/9\/javma.239.9.1232.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,1]]},"references-count":11,"journal-issue":{"issue":"9"},"URL":"https:\/\/doi.org\/10.2460\/javma.239.9.1232","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11,1]]}}}