{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:09:58Z","timestamp":1793232598597,"version":"4.5.0"},"reference-count":62,"publisher":"American Veterinary Medical Association (AVMA)","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>Once considered to be a simple cause-and-effect relationship with localized impact, the concept of how antimicrobial use drives antimicrobial resistance is now recognized as a complex, transdisciplinary problem on a global scale. While the issue of antimicrobial resistance is often studied and addressed at the antimicrobial-human or antimicrobial-animal treatment interface, the role of the environment in the One Health dynamics of antimicrobial resistance is not as well understood. Antimicrobial-resistant bacteria, including those resistant to carbapenem drugs, are emerging in veterinary clinical environments, on farms, and in natural habitats. These multidrug-resistant bacteria can colonize our livestock and companion animals and are later disseminated into the environment, where they contaminate surface waters and colonize wildlife. From here, the One Health transmission cycle of antimicrobial-resistant bacteria is completed as environmental reservoirs can serve as sources of antimicrobial resistance transmission into human or animal healthcare settings. In this review, we utilize a One Health perspective to evaluate how environments become contaminated and, in turn, become reservoirs that can colonize and infect our veterinary species, and how the veterinary field is combating environmental contamination with antimicrobial stewardship regulations and program implementation. The companion Currents in One Health by Parker et al, <jats:italic>AJVR<\/jats:italic>, April 2024, addresses the intensive research that justifies this One Health cycle of antimicrobial resistance transmission and emerging techniques that are dissecting the complex interactions at the One Health interface.<\/jats:p>","DOI":"10.2460\/javma.24.01.0056","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T14:26:30Z","timestamp":1709303190000},"page":"451-458","source":"Crossref","is-referenced-by-count":31,"title":["The One Health dissemination of antimicrobial resistance occurs in both natural and clinical environments"],"prefix":"10.2460","volume":"262","author":[{"given":"Gregory A.","family":"Ballash","sequence":"first","affiliation":[{"name":"Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Parker","sequence":"additional","affiliation":[{"name":"Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dixie F.","family":"Mollenkopf","sequence":"additional","affiliation":[{"name":"Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Wittum","sequence":"additional","affiliation":[{"name":"Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"3","key":"ref1","series-title":"Can Vet J","first-page":"240","article-title":"Effects of a perioperative antibiotic and veterinary probiotic on fecal dysbiosis index in dogs","volume":"62","author":"Lucchetti B","year":"2021","unstructured":"Lucchetti B, Lane SL, Koenig A, Good J, Suchodolski JS, Brainard BM. Effects of a perioperative antibiotic and veterinary probiotic on fecal dysbiosis index in dogs. Can Vet J. 2021;62(3):240-246."},{"issue":"1","key":"ref2","series-title":"Vet Comp Oncol","first-page":"11","article-title":"Evaluation of a multidrug chemotherapy protocol with mitoxantrone based maintenance (CHOP-MA) for the treatment of canine lymphoma","volume":"8","author":"Daters AT","year":"2010","unstructured":"Daters AT, Mauldin GE, Mauldin GN, Brodsky EM, Post GS. Evaluation of a multidrug chemotherapy protocol with mitoxantrone based maintenance (CHOP-MA) for the treatment of canine lymphoma. Vet Comp Oncol. 2010;8(1):11-22. doi:10.1111\/j.1476-5829.2009.00199.x"},{"issue":"10325","key":"ref3","series-title":"Lancet","first-page":"629","article-title":"Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis","volume":"399","author":"Antimicrobial Resistance Collaborators","year":"2022","unstructured":"Antimicrobial Resistance Collaborators. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet. 2022;399(10325):629-655. doi:10.1016\/S0140-6736(21)02724-0"},{"key":"ref4","series-title":"Government of the United Kingdom","article-title":"Tackling Drug-Resistant Infections Globally: Final Report and Recommendations. The Review of Antimicrobial Resistance","author":"O\u2019Neill J","year":"2016","unstructured":"O\u2019Neill J. Tackling Drug-Resistant Infections Globally: Final Report and Recommendations. The Review of Antimicrobial Resistance. Government of the United Kingdom; 2016."},{"key":"ref5","article-title":"CDC","author":"Antibiotic resistance threats in the United States, 2019","unstructured":"Antibiotic resistance threats in the United States, 2019. CDC. Updated November 23, 2021. Accessed December 30, 2023. https:\/\/www.cdc.gov\/drugresistance\/biggest-threats.html"},{"issue":"8","key":"ref6","series-title":"PLoS One","first-page":"e0263949","article-title":"Antimicrobial susceptibility and risk factors for resistance among Escherichia coli isolated from canine specimens submitted to a diagnostic laboratory in Indiana, 2010-2019","volume":"17","author":"Ekakoro JE","year":"2022","unstructured":"Ekakoro JE, Hendrix GK, Guptill LF, Ruple A. Antimicrobial susceptibility and risk factors for resistance among Escherichia coli isolated from canine specimens submitted to a diagnostic laboratory in Indiana, 2010-2019. PLoS One. 2022;17(8):e0263949. doi:10.1371\/journal.pone.0263949"},{"key":"ref7","series-title":"Front Vet Sci","first-page":"867784","article-title":"Antimicrobial resistance in bacteria isolated from canine urine samples submitted to a veterinary diagnostic laboratory, Illinois, United States","volume":"9","author":"Yudhanto S","year":"2022","unstructured":"Yudhanto S, Hung CC, Maddox CW, Varga C. Antimicrobial resistance in bacteria isolated from canine urine samples submitted to a veterinary diagnostic laboratory, Illinois, United States. Front Vet Sci. 2022;9:867784. doi:10.3389\/fvets.2022.867784"},{"key":"ref8","series-title":"AVMA","article-title":"Antimicrobial Resistance Pathogens Affecting Animal Health in the United States","author":"AVMA Committee on Antimicrobials","year":"2020","unstructured":"AVMA Committee on Antimicrobials. Antimicrobial Resistance Pathogens Affecting Animal Health in the United States. AVMA; 2020."},{"issue":"2","key":"ref9","series-title":"J Am Vet Med Assoc","first-page":"170","article-title":"Implementation of an antimicrobial stewardship program in a veterinary medical teaching institution","volume":"258","author":"Feyes EE","year":"2021","unstructured":"Feyes EE, Diaz-Campos D, Mollenkopf DF,  Implementation of an antimicrobial stewardship program in a veterinary medical teaching institution. J Am Vet Med Assoc. 2021;258(2):170-178. doi:10.2460\/javma.258.2.170"},{"issue":"4","key":"ref10","series-title":"Infect Control Hosp Epidemiol","first-page":"389","article-title":"The economics of antimicrobial stewardship: the current state of the art and applying the business case model","volume":"33","author":"Stevenson KB","year":"2012","unstructured":"Stevenson KB, Balada-Llasat JM, Bauer K,  The economics of antimicrobial stewardship: the current state of the art and applying the business case model. Infect Control Hosp Epidemiol. 2012;33(4):389-397. doi:10.1086\/664910"},{"key":"ref11","series-title":"United Nations Environment Programme","article-title":"Frontiers 2017 Emerging Issues of Environmental Concern","author":"United Nations Environment Programme","year":"2017","unstructured":"United Nations Environment Programme. Frontiers 2017 Emerging Issues of Environmental Concern. United Nations Environment Programme; 2017."},{"key":"ref12","series-title":"US FDA","article-title":"2022 summary report on antimicrobials sold or distributed for use in food-producing animals","unstructured":"2022 summary report on antimicrobials sold or distributed for use in food-producing animals. US FDA. Updated December 7, 2023. Accessed January 3, 2024. https:\/\/www.fda.gov\/animal-veterinary\/antimicrobial-resistance\/2022-summary-report-antimicrobials-sold-or-distributed-use-food-producing-animals"},{"issue":"1","key":"ref13","series-title":"Public Health Rep","first-page":"4","article-title":"A review of antibiotic use in food animals: perspective, policy, and potential","volume":"127","author":"Landers TF","year":"2012","unstructured":"Landers TF, Cohen B, Wittum TE, Larson EL. A review of antibiotic use in food animals: perspective, policy, and potential. Public Health Rep. 2012;127(1):4-22. doi:10.1177\/003335491212700103"},{"issue":"11","key":"ref14","series-title":"PLoS One","first-page":"e0242195","article-title":"Can the use of older-generation beta-lactam antibiotics in livestock production over-select for beta-lactamases of greatest consequence for human medicine? An in vitro experimental model","volume":"15","author":"Ogunrinu OJ","year":"2020","unstructured":"Ogunrinu OJ, Norman KN, Vinasco J,  Can the use of older-generation beta-lactam antibiotics in livestock production over-select for beta-lactamases of greatest consequence for human medicine? An in vitro experimental model. PLoS One. 2020;15(11):e0242195. doi:10.1371\/journal.pone.0242195"},{"issue":"12","key":"ref15","series-title":"Foodborne Pathog Dis","first-page":"1575","article-title":"CTX-M-type extended-spectrum \u03b2-lactamases present in Escherichia coli from the feces of cattle in Ohio, United States","volume":"7","author":"Wittum TE","year":"2010","unstructured":"Wittum TE, Mollenkopf DF, Daniels JB,  CTX-M-type extended-spectrum \u03b2-lactamases present in Escherichia coli from the feces of cattle in Ohio, United States. Foodborne Pathog Dis. 2010;7(12):1575-1579. doi:10.1089\/fpd.2010.0615"},{"issue":"13","key":"ref16","series-title":"Appl Environ Microbiol","first-page":"4552","article-title":"Variable within- and between-herd diversity of CTX-M cephalosporinase-bearing Escherichia coli isolates from dairy cattle","volume":"78","author":"Mollenkopf DF","year":"2012","unstructured":"Mollenkopf DF, Weeman MF, Daniels JB,  Variable within- and between-herd diversity of CTX-M cephalosporinase-bearing Escherichia coli isolates from dairy cattle. Appl Environ Microbiol. 2012;78(13):4552-4560. doi:10.1128\/AEM.00373-12"},{"issue":"9","key":"ref17","series-title":"Aust Vet J","first-page":"336","article-title":"Salmonella monitoring programs in Australian feed mills: a retrospective analysis","volume":"97","author":"Parker EM","year":"2019","unstructured":"Parker EM, Edwards LJ, Mollenkopf DF, Ballash GA, Wittum TE, Parker AJ. Salmonella monitoring programs in Australian feed mills: a retrospective analysis. Aust Vet J. 2019;97(9):336-342. doi:10.1111\/avj.12851"},{"issue":"5","key":"ref18","series-title":"Zoonoses Public Health","first-page":"519","article-title":"Antimicrobial-resistant Enterobacteriaceae recovered from companion animal and livestock environments","volume":"65","author":"Adams RJ","year":"2018","unstructured":"Adams RJ, Kim SS, Mollenkopf DF,  Antimicrobial-resistant Enterobacteriaceae recovered from companion animal and livestock environments. Zoonoses Public Health. 2018;65(5):519-527. doi:10.1111\/zph.12462"},{"issue":"2","key":"ref19","series-title":"Antimicrob Agents Chemother","first-page":"e01298","article-title":"Carbapenemase-producing Enterobacteriaceae recovered from the environment of a swine farrow-to-finish operation in the United States","volume":"61","author":"Mollenkopf DF","year":"2017","unstructured":"Mollenkopf DF, Stull JW, Mathys DA,  Carbapenemase-producing Enterobacteriaceae recovered from the environment of a swine farrow-to-finish operation in the United States. Antimicrob Agents Chemother. 2017;61(2):e01298-16. doi:10.1128\/AAC.01298-16"},{"key":"ref20","series-title":"Environ Res","first-page":"359","article-title":"Air exposure as a possible route for ESBL in pig farmers","volume":"155","author":"Dohmen W","year":"2017","unstructured":"Dohmen W, Schmitt H, Bonten M, Heederik D. Air exposure as a possible route for ESBL in pig farmers. Environ Res. 2017;155:359-364. doi:10.1016\/j.envres.2017.03.002"},{"key":"ref21","series-title":"Front Microbiol","first-page":"866","article-title":"Antimicrobial-resistant Escherichia coli survived in dust samples for more than 20 years","volume":"7","author":"Schulz J","year":"2016","unstructured":"Schulz J, Ruddat I, Hartung J, Hamscher G, Kemper N, Ewers C. Antimicrobial-resistant Escherichia coli survived in dust samples for more than 20 years. Front Microbiol. 2016;7:866. doi:10.3389\/fmicb.2016.00866"},{"issue":"1","key":"ref22","series-title":"Microorganisms","first-page":"17","article-title":"Impact of swine and cattle manure Treatment on the microbial composition and resistome of soil and drainage water","volume":"11","author":"Colgan P","year":"2022","unstructured":"Colgan P, Rieke EL, Nadeem K,  Impact of swine and cattle manure Treatment on the microbial composition and resistome of soil and drainage water. Microorganisms. 2022;11(1):17. doi:10.3390\/microorganisms11010017"},{"key":"ref23","series-title":"Sci Total Environ","first-page":"153518","article-title":"Impact of fertilization with pig or calf slurry on antibiotic residues and resistance genes in the soil","volume":"822","author":"Huygens J","year":"2022","unstructured":"Huygens J, Rasschaert G, Heyndrickx M,  Impact of fertilization with pig or calf slurry on antibiotic residues and resistance genes in the soil. Sci Total Environ. 2022;822:153518. doi:10.1016\/j.scitotenv.2022.153518"},{"issue":"6","key":"ref24","series-title":"J Soil Water Conserv","first-page":"360","article-title":"Assessment of the Iowa River\u2019s South Fork watershed: part 1. Water quality","volume":"63","author":"Tomer MD","year":"2008","unstructured":"Tomer MD, Moorman TB, Rossi CG. Assessment of the Iowa River\u2019s South Fork watershed: part 1. Water quality. J Soil Water Conserv. 2008;63(6):360-370. doi:10.2489\/jswc.63.6.360"},{"key":"ref25","series-title":"Sci Total Environ","first-page":"1173","article-title":"Seasonal variation of macrolide resistance gene abundances in the South Fork Iowa River Watershed","volume":"610-611","author":"Rieke EL","year":"2018","unstructured":"Rieke EL, Moorman TB, Douglass EL, Soupir ML. Seasonal variation of macrolide resistance gene abundances in the South Fork Iowa River Watershed. Sci Total Environ. 2018;610-611:1173-1179. doi:10.1016\/j.scitotenv.2017.08.116"},{"key":"ref26","series-title":"Clim Risk Manage","first-page":"e100262","article-title":"Impacts and implications of climate change on wastewater systems: a New Zealand perspective","volume":"31","author":"Hughes J","year":"2021","unstructured":"Hughes J, Cowper-Heays K, Olesson E, Bell R, Stroombergen A. Impacts and implications of climate change on wastewater systems: a New Zealand perspective. Clim Risk Manage. 2021;31:e100262. doi:10.1016\/j.crm.2020.100262"},{"issue":"7","key":"ref27","series-title":"Zoonoses Public Health","first-page":"554","article-title":"Prevalence of AmpC- and extended-spectrum \u03b2-lactamase-harbouring Enterobacteriaceae in faecal flora of a healthy domestic canine population","volume":"64","author":"Mathys DA","year":"2017","unstructured":"Mathys DA, Mollenkopf DF, Bremer CA, Daniels JB, Wittum TE. Prevalence of AmpC- and extended-spectrum \u03b2-lactamase-harbouring Enterobacteriaceae in faecal flora of a healthy domestic canine population. Zoonoses Public Health. 2017;64(7):554-560. doi:10.1111\/zph.12341"},{"issue":"15","key":"ref28","series-title":"Appl Environ Microbiol","first-page":"e0048421","article-title":"Comparison of antimicrobial-resistant Escherichia coli Isolates from urban raccoons and domestic dogs","volume":"87","author":"Worsley-Tonks KEL","year":"2021","unstructured":"Worsley-Tonks KEL, Gehrt SD, Miller EA,  Comparison of antimicrobial-resistant Escherichia coli Isolates from urban raccoons and domestic dogs. Appl Environ Microbiol. 2021;87(15):e0048421. doi:10.1128\/AEM.00484-21"},{"issue":"12","key":"ref29","series-title":"Antimicrob Agents Chemother","first-page":"e01161","article-title":"Enterobacter cloacae complex sequence type 171 isolates expressing KPC-4 carbapenemase recovered from canine patients in Ohio","volume":"62","author":"Daniels JB","year":"2018","unstructured":"Daniels JB, Chen L, Grooters SV,  Enterobacter cloacae complex sequence type 171 isolates expressing KPC-4 carbapenemase recovered from canine patients in Ohio. Antimicrob Agents Chemother. 2018;62(12):e01161-18. doi:10.1128\/AAC.01161-18"},{"issue":"2","key":"ref30","series-title":"Emerg Infect Dis","first-page":"381","article-title":"New Delhi metallo-\u03b2-lactamase-5-producing Escherichia coli in companion animals, United States","volume":"26","author":"Cole SD","year":"2020","unstructured":"Cole SD, Peak L, Tyson GH, Reimschuessel R, Ceric O, Rankin SC. New Delhi metallo-\u03b2-lactamase-5-producing Escherichia coli in companion animals, United States. Emerg Infect Dis. 2020;26(2):381-383. doi:10.3201\/eid2602.191221"},{"key":"ref31","series-title":"eLife","first-page":"e00458","article-title":"Cohabiting family members share microbiota with one another and with their dogs","volume":"2","author":"Song SJ","year":"2013","unstructured":"Song SJ, Lauber C, Costello EK,  Cohabiting family members share microbiota with one another and with their dogs. eLife. 2013;2:e00458. doi:10.7554\/eLife.00458"},{"issue":"8","key":"ref32","series-title":"Zoonoses Public Health","first-page":"947","article-title":"Longitudinal environmental Staphylococcus contamination in a new small animal veterinary hospital and utility of cleaning checklists","volume":"68","author":"Hunter ND","year":"2021","unstructured":"Hunter ND, Hoet AE, van Balen J, Stull JW. Longitudinal environmental Staphylococcus contamination in a new small animal veterinary hospital and utility of cleaning checklists. Zoonoses Public Health. 2021;68(8):947-954. doi:10.1111\/zph.12887"},{"issue":"11","key":"ref33","series-title":"Vector Borne Zoonotic Dis","first-page":"620","article-title":"\u03b2-lactam and fluoroquinolone-resistant Enterobacteriaceae recovered from the environment of human and veterinary tertiary care hospitals","volume":"18","author":"Mathys DA","year":"2018","unstructured":"Mathys DA, Mollenkopf DF, Van Balen JC, Wittum TE. \u03b2-lactam and fluoroquinolone-resistant Enterobacteriaceae recovered from the environment of human and veterinary tertiary care hospitals. Vector Borne Zoonotic Dis. 2018;18(11):620-623. doi:10.1089\/vbz.2018.2320"},{"issue":"2","key":"ref34","series-title":"Infect Prev Pract","first-page":"100209","article-title":"Role of the environment in transmission of gram-negative bacteria in two consecutive outbreaks in a haematology-oncology department","volume":"4","author":"van der Zwet WC","year":"2022","unstructured":"van der Zwet WC, Nijsen IEJ, Jamin C,  Role of the environment in transmission of gram-negative bacteria in two consecutive outbreaks in a haematology-oncology department. Infect Prev Pract. 2022;4(2):100209. doi:10.1016\/j.infpip.2022.100209"},{"key":"ref35","series-title":"J Hosp Infect","first-page":"39","article-title":"Impact of sink design on bacterial transmission from hospital sink drains to the surrounding sink environment tested using a fluorescent marker","volume":"127","author":"Pirzadian J","year":"2022","unstructured":"Pirzadian J, Souhoka T, Herweijer M,  Impact of sink design on bacterial transmission from hospital sink drains to the surrounding sink environment tested using a fluorescent marker. J Hosp Infect. 2022;127:39-43. doi:10.1016\/j.jhin.2022.04.017"},{"issue":"13","key":"ref36","series-title":"N Engl J Med","first-page":"1198","article-title":"Emerging Infections Program Healthcare-Associated Infections and Antimicrobial Use Prevalence Survey Team. Multistate point-prevalence survey of health care-associated infections","volume":"370","author":"Magill SS","year":"2014","unstructured":"Magill SS, Edwards JR, Bamberg W, ; Emerging Infections Program Healthcare-Associated Infections and Antimicrobial Use Prevalence Survey Team. Multistate point-prevalence survey of health care-associated infections. N Engl J Med. 2014;370(13):1198-1208. doi:10.1056\/NEJMoa1306801"},{"issue":"1","key":"ref37","series-title":"Sci Rep","first-page":"1647","article-title":"Evaluation of nosocomial infections through contact patterns in a small animal hospital using social network analysis and genotyping techniques","volume":"11","author":"Churak A","year":"2021","unstructured":"Churak A, Poolkhet C, Tamura Y, Sato T, Fukuda A, Thongratsakul S. Evaluation of nosocomial infections through contact patterns in a small animal hospital using social network analysis and genotyping techniques. Sci Rep. 2021;11(1):1647. doi:10.1038\/s41598-021-81301-9"},{"issue":"5","key":"ref38","series-title":"Vector Borne Zoonotic Dis","first-page":"299","article-title":"Presence, distribution, and molecular epidemiology of methicillin-resistant Staphylococcus aureus in a small animal teaching hospital: a year-long active surveillance targeting dogs and their environment","volume":"13","author":"van Balen J","year":"2013","unstructured":"van Balen J, Kelley C, Nava-Hoet RC,  Presence, distribution, and molecular epidemiology of methicillin-resistant Staphylococcus aureus in a small animal teaching hospital: a year-long active surveillance targeting dogs and their environment. Vector Borne Zoonotic Dis. 2013;13(5):299-311. doi:10.1089\/vbz.2012.1142"},{"issue":"3","key":"ref39","series-title":"J Theor Biol","first-page":"655","article-title":"Controlling nosocomial infection based on structure of hospital social networks","volume":"254","author":"Ueno T","year":"2008","unstructured":"Ueno T, Masuda N. Controlling nosocomial infection based on structure of hospital social networks. J Theor Biol. 2008;254(3):655-666. doi:10.1016\/j.jtbi.2008.07.001"},{"issue":"1","key":"ref40","series-title":"Sci Rep","first-page":"10009","article-title":"Mobile phones are hazardous microbial platforms warranting robust public health and biosecurity protocols","volume":"12","author":"Olsen M","year":"2022","unstructured":"Olsen M, Nassar R, Senok A,  Mobile phones are hazardous microbial platforms warranting robust public health and biosecurity protocols. Sci Rep. 2022;12(1):10009. doi:10.1038\/s41598-022-14118-9"},{"issue":"5","key":"ref41","series-title":"Nat Rev Microbiol","first-page":"257","article-title":"Antibiotic resistance in the environment","volume":"20","author":"Larsson DGJ","year":"2022","unstructured":"Larsson DGJ, Flach CF. Antibiotic resistance in the environment. Nat Rev Microbiol. 2022;20(5):257-269. doi:10.1038\/s41579-021-00649-x"},{"issue":"7","key":"ref42","series-title":"PLoS One","first-page":"e0132586","article-title":"Antimicrobial-resistant bacterial populations and antimicrobial resistance genes obtained from environments impacted by livestock and municipal waste","volume":"10","author":"Agga GE","year":"2015","unstructured":"Agga GE, Arthur TM, Durso LM, Harhay DM, Schmidt JW. Antimicrobial-resistant bacterial populations and antimicrobial resistance genes obtained from environments impacted by livestock and municipal waste. PLoS One. 2015;10(7):e0132586. doi:10.1371\/journal.pone.0132586"},{"key":"ref43","series-title":"Front Microbiol","first-page":"657954","article-title":"Evaluation of metagenomic-enabled antibiotic resistance surveillance at a conventional wastewater treatment plant","volume":"12","author":"Majeed HJ","year":"2021","unstructured":"Majeed HJ, Riquelme MV, Davis BC,  Evaluation of metagenomic-enabled antibiotic resistance surveillance at a conventional wastewater treatment plant. Front Microbiol. 2021;12:657954. doi:10.3389\/fmicb.2021.657954"},{"issue":"6","key":"ref44","series-title":"PLoS One","first-page":"e0218650","article-title":"Carbapenemase-producing Enterobacteriaceae and Aeromonas spp. present in wastewater treatment plant effluent and nearby surface waters in the US","volume":"14","author":"Mathys DA","year":"2019","unstructured":"Mathys DA, Mollenkopf DF, Feicht SM,  Carbapenemase-producing Enterobacteriaceae and Aeromonas spp. present in wastewater treatment plant effluent and nearby surface waters in the US. PLoS One. 2019;14(6):e0218650. doi:10.1371\/journal.pone.0218650"},{"issue":"pt 1","key":"ref45","series-title":"Sci Total Environ","first-page":"158042","article-title":"Comparison of environmental microbiomes in an antibiotic resistance-polluted urban river highlights periphyton and fish gut communities as reservoirs of concern","volume":"851","author":"Mills M","year":"2022","unstructured":"Mills M, Lee S, Mollenkopf D, Wittum T, Sullivan SMP, Lee J. Comparison of environmental microbiomes in an antibiotic resistance-polluted urban river highlights periphyton and fish gut communities as reservoirs of concern. Sci Total Environ. 2022;851(pt 1):158042. doi:10.1016\/j.scitotenv.2022.158042"},{"issue":"9","key":"ref46","series-title":"PLoS One","first-page":"e0272806","article-title":"Fish as sentinels of antimicrobial resistant bacteria, epidemic carbapenemase genes, and antibiotics in surface water","volume":"17","author":"Ballash GA","year":"2022","unstructured":"Ballash GA, Baesu A, Lee S,  Fish as sentinels of antimicrobial resistant bacteria, epidemic carbapenemase genes, and antibiotics in surface water. PLoS One. 2022;17(9):e0272806. doi:10.1371\/journal.pone.0272806"},{"issue":"13","key":"ref47","series-title":"Appl Environ Microbiol","first-page":"e0046522","article-title":"Colonization of white-tailed deer (Odocoileus virginianus) from urban and suburban environments with cephalosporinase- and carbapenemase-producing Enterobacterales","volume":"88","author":"Ballash GA","year":"2022","unstructured":"Ballash GA, Dennis PM, Mollenkopf DF,  Colonization of white-tailed deer (Odocoileus virginianus) from urban and suburban environments with cephalosporinase- and carbapenemase-producing Enterobacterales. Appl Environ Microbiol. 2022;88(13):e0046522. doi:10.1128\/aem.00465-22"},{"issue":"5","key":"ref48","series-title":"J Environ Qual","first-page":"1068","article-title":"Antimicrobial-resistant E","volume":"47","author":"Taggar G","year":"2018","unstructured":"Taggar G, Rehman MA, Yin X,  Antimicrobial-resistant E. coli from surface waters in southwest Ontario dairy farms. J Environ Qual. 2018;47(5):1068-1078. doi:10.2134\/jeq2018.04.0139"},{"key":"ref49","series-title":"Sci Total Environ","first-page":"166753","article-title":"Simultaneous stream assessment of antibiotics, bacteria, antibiotic resistant bacteria, and antibiotic resistance genes in an agricultural region of the United States","volume":"904","author":"Givens CE","year":"2023","unstructured":"Givens CE, Kolpin DW, Hubbard LE,  Simultaneous stream assessment of antibiotics, bacteria, antibiotic resistant bacteria, and antibiotic resistance genes in an agricultural region of the United States. Sci Total Environ. 2023;904:166753. doi:10.1016\/j.scitotenv.2023.166753"},{"key":"ref50","series-title":"Environ Int","first-page":"326","article-title":"Exposure to and colonisation by antibiotic-resistant E","volume":"114","author":"Leonard AFC","year":"2018","unstructured":"Leonard AFC, Zhang L, Balfour AJ,  Exposure to and colonisation by antibiotic-resistant E. coli in UK coastal water users: environmental surveillance, exposure assessment, and epidemiological study (Beach Bum Survey). Environ Int. 2018;114:326-333. doi:10.1016\/j.envint.2017.11.003"},{"issue":"12","key":"ref51","series-title":"Poult Sci","first-page":"101485","article-title":"Antibiotic resistance genes in layer farms and their correlation with environmental samples","volume":"100","author":"Zhu T","year":"2021","unstructured":"Zhu T, Chen T, Cao Z,  Antibiotic resistance genes in layer farms and their correlation with environmental samples. Poult Sci. 2021;100(12):101485. doi:10.1016\/j.psj.2021.101485"},{"issue":"1","key":"ref52","series-title":"Sci Rep","first-page":"11999","article-title":"Pig manure treatment strategies for mitigating the spread of antibiotic resistance","volume":"13","author":"Zalewska M","year":"2023","unstructured":"Zalewska M, B\u0142a\u017cejewska A, Czapko A, Popowska M. Pig manure treatment strategies for mitigating the spread of antibiotic resistance. Sci Rep. 2023;13(1):11999. doi:10.1038\/s41598-023-39204-4"},{"key":"ref53","series-title":"J Environ Manage","first-page":"110529","article-title":"Pulsed electric field application reduces carbapenem- and colistin-resistant microbiota and blaKPC spread in urban wastewater","volume":"265","author":"Ballash GA","year":"2020","unstructured":"Ballash GA, Lee S, Mollenkopf DF,  Pulsed electric field application reduces carbapenem- and colistin-resistant microbiota and blaKPC spread in urban wastewater. J Environ Manage. 2020;265:110529. doi:10.1016\/j.jenvman.2020.110529"},{"issue":"8","key":"ref54","series-title":"Microorganisms","first-page":"1525","article-title":"The impact of antimicrobial stewardship training on calf producers\u2019 knowledge, treatment behaviors and quantified antimicrobial use","volume":"10","author":"Pempek J","year":"2022","unstructured":"Pempek J, Masterson M, Portillo-Gonzalez R, Creutzinger K, Cheng TY, Habing G. The impact of antimicrobial stewardship training on calf producers\u2019 knowledge, treatment behaviors and quantified antimicrobial use. Microorganisms. 2022;10(8):1525. doi:10.3390\/microorganisms10081525"},{"key":"ref55","series-title":"J Dairy Sci","article-title":"Effect of a dairy farmworker stewardship training program on antimicrobial drug usage in dairy cows","author":"Portillo-Gonzalez R","unstructured":"Portillo-Gonzalez R, Garzon A, Pereira RVV, Silva-Del-Rio N, Karle BM, Habing GG. Effect of a dairy farmworker stewardship training program on antimicrobial drug usage in dairy cows. J Dairy Sci. Published online December 4, 2023. doi:10.3168\/jds.2023-23663"},{"issue":"6","key":"ref56","series-title":"J Dairy Sci","first-page":"4171","article-title":"Antimicrobial stewardship on the dairy: evaluating an on-farm framework for training farmworkers","volume":"106","author":"Garzon A","year":"2023","unstructured":"Garzon A, Portillo R, Habing G, Silva-Del-Rio N, Karle BM, Pereira RV. Antimicrobial stewardship on the dairy: evaluating an on-farm framework for training farmworkers. J Dairy Sci. 2023;106(6):4171-4183. doi:10.3168\/jds.2022-22560"},{"issue":"S1","key":"ref57","series-title":"Infect Control Hosp Epidemiol","first-page":"s409","article-title":"The implementation of active environmental surveillance in a veterinary referral hospital setting","volume":"41","author":"Feyes E","year":"2020","unstructured":"Feyes E, Mollenkopf D, Wittum T, Diaz-Campos D, Horne R. The implementation of active environmental surveillance in a veterinary referral hospital setting. Infect Control Hosp Epidemiol. 2020;41(S1):s409. doi:10.1017\/ice.2020.1060."},{"issue":"9","key":"ref58","series-title":"Clin Infect Dis","first-page":"1074","article-title":"An antimicrobial stewardship program\u2019s impact with rapid polymerase chain reaction methicillin-resistant Staphylococcus aureus\/S. aureus blood culture test in patients with S. aureus bacteremia","volume":"51","author":"Bauer KA","year":"2010","unstructured":"Bauer KA, West JE, Balada-Llasat JM, Pancholi P, Stevenson KB, Goff DA. An antimicrobial stewardship program\u2019s impact with rapid polymerase chain reaction methicillin-resistant Staphylococcus aureus\/S. aureus blood culture test in patients with S. aureus bacteremia. Clin Infect Dis. 2010;51(9):1074-1080. doi:10.1086\/656623"},{"key":"ref59","article-title":"Animal Medicinal Drug Use Clarification Act of 1994 (AMDUCA). US FDA","unstructured":"Animal Medicinal Drug Use Clarification Act of 1994 (AMDUCA). US FDA. Updated April 4, 2023. Accessed January 6, 2024. https:\/\/www.fda.gov\/animal-veterinary\/guidance-regulations\/animal-medicinal-drug-use-clarification-act-1994-amduca#extralabel"},{"key":"ref60","article-title":"Veterinary Feed Directive (VFD). US FDA","unstructured":"Veterinary Feed Directive (VFD). US FDA. Updated January 3, 2024. Accessed January 5, 2024. https:\/\/www.fda.gov\/animal-veterinary\/development-approval-process\/veterinary-feed-directive-vfd"},{"key":"ref61","article-title":"Guidance for Industry #263. US FDA","unstructured":"Guidance for Industry #263. US FDA. Updated June 12, 2023. Accessed January 8, 2024. https:\/\/www.fda.gov\/animal-veterinary\/cvm-updates\/fda-announces-transition-over-counter-medically-important-antimicrobials-animals-prescription-status"},{"issue":"10","key":"ref62","series-title":"Lancet Infect Dis","first-page":"1161","article-title":"Changes in colistin resistance and mcr-1 abundance in Escherichia coli of animal and human origins following the ban of colistin-positive additives in China: an epidemiological comparative study","volume":"20","author":"Wang Y","year":"2020","unstructured":"Wang Y, Xu C, Zhang R,  Changes in colistin resistance and mcr-1 abundance in Escherichia coli of animal and human origins following the ban of colistin-positive additives in China: an epidemiological comparative study. Lancet Infect Dis. 2020;20(10):1161-1171. doi:10.1016\/S1473-3099(20)30149-3"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/262\/4\/javma.24.01.0056.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/262\/4\/javma.24.01.0056.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/262\/4\/javma.24.01.0056.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T21:52:39Z","timestamp":1727301159000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/262\/4\/javma.24.01.0056.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,1]]},"references-count":62,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.2460\/javma.24.01.0056","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4,1]]}}}