{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:54:10Z","timestamp":1787025250298,"version":"build-2736575974"},"reference-count":5,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"Abstract<\/jats:title>\n \n OBJECTIVE<\/jats:title>\n To describe a novel presentation of paraneoplastic hypercalcemia caused by a canine salivary carcinoma.<\/jats:p>\n <\/jats:sec>\n \n ANIMAL<\/jats:title>\n A 6-year-old intact male Husky with hypercalcemia and a spontaneous salivary carcinoma, stage III.<\/jats:p>\n <\/jats:sec>\n \n CLINICAL PRESENTATION, PROGRESSION, AND PROCEDURES<\/jats:title>\n The dog presented with polyuria, polydipsia, and hypercalcemia. Physical examination revealed a 37 X 43-mm firm mass in the ventrolateral aspect of the right-hand side of the neck, caudal to the temporomandibular joint. Incisional biopsy was suspicious of metastatic carcinoma to the mandibular lymph node. A full-body CT scan found a large, heterogenous, contrast-enhancing mass on the right ventrolateral neck that appeared to be originating from either the mandibular lymph node or right mandibular salivary gland. Parathyroid hormone\u2013related protein was considered within normal reference intervals, and both parathyroid glands appeared ultrasonographically normal.<\/jats:p>\n <\/jats:sec>\n \n TREATMENT AND OUTCOME<\/jats:title>\n The patient was treated with a marginal surgical excision of the mass, without immediate complications. Histopathology confirmed the presence of a salivary carcinoma with narrow margins of excision and invasion of the mandibular lymph node. Twenty-four hours after surgery, ionized calcium returned to normal reference values and clinical signs completely resolved.<\/jats:p>\n <\/jats:sec>\n \n CLINICAL RELEVANCE<\/jats:title>\n Hypercalcemia is an urgent pathology with important systemic implications requiring prompt diagnosis and intervention. In this case report, we identify the first salivary carcinoma associated with a paraneoplastic hypercalcemia, including this pathology as a new differential diagnosis. The hypercalcemia resolved with marginal surgical excision, but interestingly the parathyroid hormone\u2013related protein was not overexpressed, meaning that this neoplasia could mediate hypercalcemia by another pathophysiological mechanism.<\/jats:p>\n <\/jats:sec>","DOI":"10.2460\/javma.24.01.0058","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T15:41:51Z","timestamp":1713973311000},"page":"1-4","source":"Crossref","is-referenced-by-count":1,"title":["Paraneoplastic hypercalcemia in a canine patient with a mandibular salivary carcinoma"],"prefix":"10.2460","volume":"262","author":[{"given":"Pablo","family":"Delgado-Bonet","sequence":"first","affiliation":[{"name":"Small Animal Hospital, School of Veterinary Medicine, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Coe","sequence":"additional","affiliation":[{"name":"Small Animal Hospital, School of Veterinary Medicine, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gawain J. C.","family":"Hammond","sequence":"additional","affiliation":[{"name":"Small Animal Hospital, School of Veterinary Medicine, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A.","family":"Wennerdahl","sequence":"additional","affiliation":[{"name":"Idexx Laboratories Inc, Westbrook, ME"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie A.","family":"McNaught","sequence":"additional","affiliation":[{"name":"Small Animal Hospital, School of Veterinary Medicine, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"4","key":"ref1","series-title":"J Vet Diagn Invest.","first-page":"604","article-title":"A retrospective study of salivary gland diseases in 179 dogs (2010-2018)","volume":"32","author":"Lieske DE","year":"2020","unstructured":"Lieske DE, Rissi DR. A retrospective study of salivary gland diseases in 179 dogs (2010-2018). J Vet Diagn Invest. 2020;32(4):604-610. doi:10.1177\/1040638720932169"},{"issue":"3","key":"ref2","series-title":"Vet Surg.","first-page":"370","article-title":"Outcomes and clinical features associated with surgically excised canine salivary gland carcinoma: a multi-institutional, retrospective, Veterinary Society of Surgical Oncology study","volume":"52","author":"Bush KM","year":"2023","unstructured":"Bush KM, Grimes JA, Linden DS, Outcomes and clinical features associated with surgically excised canine salivary gland carcinoma: a multi-institutional, retrospective, Veterinary Society of Surgical Oncology study. Vet Surg. 2023;52(3):370-378. doi:10.1111\/vsu.13928"},{"issue":"5","key":"ref3","series-title":"J Am Anim Hosp Assoc.","first-page":"478","article-title":"Salivary gland neoplasia in the dog and cat: survival times and prognostic factors","volume":"37","author":"Hammer A","year":"2001","unstructured":"Hammer A, Getzy D, Ogilvie G, Upton M, Klausner J, Kisseberth WC. Salivary gland neoplasia in the dog and cat: survival times and prognostic factors. J Am Anim Hosp Assoc. 2001;37(5):478-482. doi:10.5326\/15473317-37-5-478"},{"issue":"3","key":"ref4","series-title":"J Vet Intern Med.","first-page":"514","article-title":"Ionized hypercalcemia in dogs: a retrospective study of 109 cases (1998-2003)","volume":"23","author":"Messinger JS","year":"2009","unstructured":"Messinger JS, Windham WR, Ward CR. Ionized hypercalcemia in dogs: a retrospective study of 109 cases (1998-2003). J Vet Intern Med. 2009;23(3):514-519. doi:10.1111\/j.1939-1676.2009.0288.x"},{"issue":"6","key":"ref5","series-title":"Curr Opin Endocrinol Diabetes Obes.","first-page":"339","article-title":"Mechanisms and treatment of hypercalcemia of malignancy","volume":"18","author":"Clines GA","year":"2011","unstructured":"Clines GA. Mechanisms and treatment of hypercalcemia of malignancy. Curr Opin Endocrinol Diabetes Obes. 2011;18(6):339-346. doi:10.1097\/MED.0b013e32834b4401"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/262\/8\/javma.24.01.0058.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/262\/8\/javma.24.01.0058.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/262\/8\/javma.24.01.0058.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T09:12:44Z","timestamp":1741338764000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/262\/8\/javma.24.01.0058.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,1]]},"references-count":5,"journal-issue":{"issue":"8"},"URL":"https:\/\/doi.org\/10.2460\/javma.24.01.0058","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8,1]]}}}