{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:34:40Z","timestamp":1792542880616,"version":"4.5.0"},"reference-count":21,"publisher":"American Veterinary Medical Association (AVMA)","issue":"S2","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"sc_a1\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To determine the predictive value of corneal ultrasound biomicroscopy (UBM) findings for the outcome of equine corneal disease.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a2\">\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>46 horses with a clinical diagnosis of either infectious ulcerative keratitis or stromal abscess.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a3\">\n<jats:title>METHODS<\/jats:title>\n<jats:p>Corneal UBM (VevoMD; UHF70; VisualSonics) of horses with infectious corneal disease presenting to the North Carolina State University Equine Ophthalmology Service from 2019 to 2023 were evaluated. Size and depth of lesion, presence of Descemet membrane disruption (DMD), corneal thickness, and aqueous humor cell counts (AHCC) were assessed. Comparisons of UBM and clinical exam findings, presence of infectious organisms, and outcome (healed or enucleated) were performed.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a4\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>The UBMs from 46 horses were evaluated. Increased AHCC was significantly associated with increased size and depth of corneal lesions on UBM but not with DMD. Deep lesions and DMD were significantly associated with an enucleation outcome. Horses treated with systemic antibiotics had significantly lower AHCC on UBM, but there were no differences in AHCC with the use of other systemic or topical medications. There was no significant correlation between infectious disease results, clinical findings (aqueous flare or cells), outcome, and UBM AHCC.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a5\">\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Parameters on UBM, such as depth of lesion, DMD, and AHCC, may be useful diagnostic and prognostic tools to augment the ophthalmic exam of horses with corneal disease. The UBM findings of deep corneal lesions and DMD suggest a poor prognosis and warrant aggressive surgical intervention.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.24.02.0097","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T12:39:50Z","timestamp":1717159190000},"page":"S57-S64","source":"Crossref","is-referenced-by-count":3,"title":["Ultrasound biomicroscopic imaging parameters associated with outcome in equine infectious ulcerative keratitis and stromal abscesses"],"prefix":"10.2460","volume":"262","author":[{"given":"Elisabeth N.","family":"Collins","sequence":"first","affiliation":[{"name":"Clinical Sciences, North Carolina State University College of Veterinary Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin M.","family":"Barr","sequence":"additional","affiliation":[{"name":"Clinical Sciences, North Carolina State University College of Veterinary Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Westermeyer","sequence":"additional","affiliation":[{"name":"Clinical Sciences, North Carolina State University College of Veterinary Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7771-9166","authenticated-orcid":true,"given":"Brian C.","family":"Gilger","sequence":"additional","affiliation":[{"name":"Clinical Sciences, North Carolina State University College of Veterinary Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Oh","sequence":"additional","affiliation":[{"name":"Clinical Sciences, North Carolina State University College of Veterinary Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"B1","series-title":"Equine Ophthalmology","first-page":"253","article-title":"Diseases of the equine cornea","author":"Brooks DE","year":"2022","unstructured":"Brooks DE, Plummer CE. 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