{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:54:29Z","timestamp":1793123669697,"version":"4.5.0"},"reference-count":112,"publisher":"American Veterinary Medical Association (AVMA)","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>Acute-onset pancreatitis (AP) is common in dogs and presents diagnostic as well as management challenges. Until recently, the management of AP in dogs was based mainly on supportive and symptomatic care. Identification and management of a possible cause of the disease is important, but the majority of cases are considered to be idiopathic. Fluid therapy that is tailored to the patient\u2019s needs is crucial to provide adequate hydration while preventing overhydration. Antiemetics are required to control vomiting and fluid loss and aid in early nutritional support. Recognition and management of complications is also crucial. Furthermore, analgesics for abdominal pain are very important. More recently, pharmaceutical modification of the inflammatory cascade has gained interest and the first specific therapeutic agent for the treatment of AP, fuzapladib sodium, has been shown to have a reasonable expectation of effectiveness in a pilot study. This drug has been licensed for the treatment of clinical signs of AP in dogs in Japan and also has achieved FDA conditional approval in the US. Antibiotics should not be used indiscriminately but are indicated for patients with aspiration pneumonia, gastrointestinal bacterial translocation, or evidence of another bacterial infection. Proton pump inhibitors and plasma are not routinely prescribed in pancreatitis unless specifically indicated. Nonsteroidal anti-inflammatory drugs should be avoided. Corticosteroid therapy, once thought to be contraindicated, may have some beneficial effects, as shown in a single retrospective study. However, further studies are required before their routine use can be recommended. Finally, a surgical approach is rarely indicated.<\/jats:p>","DOI":"10.2460\/javma.24.02.0107","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T19:58:58Z","timestamp":1717617538000},"page":"1231-1240","source":"Crossref","is-referenced-by-count":19,"title":["Management of acute-onset pancreatitis in dogs: a Narrative Review"],"prefix":"10.2460","volume":"262","author":[{"given":"Sue Yee","family":"Lim","sequence":"first","affiliation":[{"name":"Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Cridge","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Twedt","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Science, Colorado State University, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ohta","sequence":"additional","affiliation":[{"name":"Companion Animal Internal Medicine, Department of Companion Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaomi","family":"Nuruki","sequence":"additional","affiliation":[{"name":"TRVA Animal Medical Center, Setagaya City, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg M.","family":"Steiner","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"4","key":"ref1","series-title":"J Vet Intern Med","first-page":"488","article-title":"Localization of pancreatic inflammation and necrosis in dogs","volume":"18","author":"Newman S","year":"2004","unstructured":"Newman S, Steiner J, Woosley K, Barton L, Ruaux C, Williams D. Localization of pancreatic inflammation and necrosis in dogs. J Vet Intern Med. 2004;18(4):488-493. doi:10.1892\/0891-6640(2004)18<488:lopian>2.0.co;2"},{"issue":"4","key":"ref2","series-title":"Vet Ther","first-page":"263","article-title":"Sensitivity of serum markers for pancreatitis in dogs with macroscopic evidence of pancreatitis","volume":"9","author":"Steiner JM","year":"2008","unstructured":"Steiner JM, Newman S, Xenoulis P,  Sensitivity of serum markers for pancreatitis in dogs with macroscopic evidence of pancreatitis. Vet Ther. 2008;9(4):263-273."},{"issue":"4","key":"ref3","series-title":"J Vet Intern Med","first-page":"888","article-title":"A multi-institutional study evaluating the diagnostic utility of the Spec cPL and SNAP cPL in clinical acute pancreatitis in 84 dogs","volume":"26","author":"McCord K","year":"2012","unstructured":"McCord K, Morley PS, Armstrong J,  A multi-institutional study evaluating the diagnostic utility of the Spec cPL and SNAP cPL in clinical acute pancreatitis in 84 dogs. J Vet Intern Med. 2012;26(4):888-896. doi:10.1111\/j.1939-1676.2012.00951.x"},{"issue":"6","key":"ref4","series-title":"J Trauma Acute Care Surg","first-page":"888","article-title":"Executive summary: WSES guidelines for the management of severe acute pancreatitis","volume":"88","author":"Lepp\u00e4niemi A","year":"2020","unstructured":"Lepp\u00e4niemi A, Tolonen M, Tarasconi A,  Executive summary: WSES guidelines for the management of severe acute pancreatitis. J Trauma Acute Care Surg. 2020;88(6):888-890. doi:10.1097\/TA.0000000000002691"},{"issue":"1","key":"ref5","series-title":"J Small Anim Pract","first-page":"27","article-title":"Management of acute pancreatitis in dogs: a critical appraisal with focus on feeding and analgesia","volume":"56","author":"Mansfield C","year":"2015","unstructured":"Mansfield C, Beths T. Management of acute pancreatitis in dogs: a critical appraisal with focus on feeding and analgesia. J Small Anim Pract. 2015;56(1):27-39. doi:10.1111\/jsap.12296"},{"issue":"6","key":"ref6","series-title":"J Vet Intern Med","first-page":"2084","article-title":"Fuzapladib in a randomized controlled multicenter masked study in dogs with presumptive acute onset pancreatitis","volume":"37","author":"Steiner JM","year":"2023","unstructured":"Steiner JM, Lainesse C, Noshiro Y,  Fuzapladib in a randomized controlled multicenter masked study in dogs with presumptive acute onset pancreatitis. J Vet Intern Med. 2023;37(6):2084-2092. doi:10.1111\/jvim.16897"},{"issue":"3","key":"ref7","series-title":"J Vet Intern Med","first-page":"847","article-title":"New insights into the etiology, risk factors, and pathogenesis of pancreatitis in dogs: potential impacts on clinical practice","volume":"36","author":"Cridge H","year":"2022","unstructured":"Cridge H, Lim SY, Alg\u00fcl H, Steiner JM. New insights into the etiology, risk factors, and pathogenesis of pancreatitis in dogs: potential impacts on clinical practice. J Vet Intern Med. 2022;36(3):847-864. doi:10.1111\/jvim.16437"},{"issue":"9","key":"ref8","series-title":"J Am Vet Med Assoc","first-page":"1425","article-title":"Associations between dietary factors and pancreatitis in dogs","volume":"233","author":"Lem KY","year":"2008","unstructured":"Lem KY, Fosgate GT, Norby B, Steiner JM. Associations between dietary factors and pancreatitis in dogs. J Am Vet Med Assoc. 2008;233(9):1425-1431. doi:10.2460\/javma.233.9.1425"},{"issue":"5","key":"ref9","series-title":"J Am Vet Med Assoc","first-page":"665","article-title":"Clinical, clinicopathologic, radiographic, and ultrasonographic abnormalities in dogs with fatal acute pancreatitis: 70 cases (1986-1995)","volume":"213","author":"Hess RS","year":"1998","unstructured":"Hess RS, Saunders HM, Van Winkle TJ, Shofer FS, Washabau RJ. Clinical, clinicopathologic, radiographic, and ultrasonographic abnormalities in dogs with fatal acute pancreatitis: 70 cases (1986-1995). J Am Vet Med Assoc. 1998;213(5):665-670. doi:10.2460\/javma.1998.213.05.665"},{"issue":"4","key":"ref10","series-title":"J Am Anim Hosp Assoc","first-page":"229","article-title":"Association between serum triglyceride and canine pancreatic lipase immunoreactivity concentrations in miniature schnauzers","volume":"46","author":"Xenoulis PG","year":"2010","unstructured":"Xenoulis PG, Suchodolski JS, Ruaux CG, Steiner JM. Association between serum triglyceride and canine pancreatic lipase immunoreactivity concentrations in miniature schnauzers. J Am Anim Hosp Assoc. 2010;46(4):229-234. doi:10.5326\/0460229"},{"issue":"5","key":"ref11","series-title":"Am J Vet Res","first-page":"527","article-title":"Identification of variants of the SPINK1 gene and their association with pancreatitis in miniature schnauzers","volume":"71","author":"Bishop MA","year":"2010","unstructured":"Bishop MA, Xenoulis PG, Levinski MD, Suchodolski JS, Steiner JM. Identification of variants of the SPINK1 gene and their association with pancreatitis in miniature schnauzers. Am J Vet Res. 2010;71(5):527-533. doi:10.2460\/ajvr.71.5.527"},{"issue":"6","key":"ref12","series-title":"J Vet Intern Med","first-page":"1295","article-title":"High prevalence of the c.74A>C SPINK1 variant in miniature and standard schnauzers","volume":"26","author":"Furrow E","year":"2012","unstructured":"Furrow E, Armstrong PJ, Patterson EE. High prevalence of the c.74A>C SPINK1 variant in miniature and standard schnauzers. J Vet Intern Med. 2012;26(6):1295-1299. doi:10.1111\/j.1939-1676.2012.01013.x"},{"issue":"5","key":"ref13","series-title":"Pancreatology","first-page":"795","article-title":"Hypertriglyceridemia and acute pancreatitis","volume":"20","author":"Yang AL","year":"2020","unstructured":"Yang AL, McNabb-Baltar J. Hypertriglyceridemia and acute pancreatitis. Pancreatology. 2020;20(5):795-800. doi:10.1016\/j.pan.2020.06.005"},{"issue":"1","key":"ref14","series-title":"J Vet Intern Med","first-page":"20","article-title":"Serum triglyceride concentrations in miniature schnauzers with and without a history of probable pancreatitis","volume":"25","author":"Xenoulis PG","year":"2011","unstructured":"Xenoulis PG, Levinski MD, Suchodolski JS, Steiner JM. Serum triglyceride concentrations in miniature schnauzers with and without a history of probable pancreatitis. J Vet Intern Med. 2011;25(1):20-25. doi:10.1111\/j.1939-1676.2010.0644.x"},{"issue":"7","key":"ref15","series-title":"Can Vet J","first-page":"555","article-title":"Pancreatitis associated with potassium bromide\/phenobarbital combination therapy in epileptic dogs","volume":"41","author":"Gaskill CL","year":"2000","unstructured":"Gaskill CL, Cribb AE. Pancreatitis associated with potassium bromide\/phenobarbital combination therapy in epileptic dogs. Can Vet J. 2000;41(7):555-558."},{"issue":"2","key":"ref16","series-title":"Can J Vet Res","first-page":"103","article-title":"A pilot study evaluating changes in pancreatic lipase immunoreactivity concentrations in canines treated with L-asparaginase (ASNase), vincristine, or both for lymphoma","volume":"73","author":"Wright Z","year":"2009","unstructured":"Wright Z, Steiner J, Suchodolski J, Rogers K, Barton C, Brown M. A pilot study evaluating changes in pancreatic lipase immunoreactivity concentrations in canines treated with L-asparaginase (ASNase), vincristine, or both for lymphoma. Can J Vet Res. 2009;73(2):103-110."},{"issue":"5","key":"ref17","series-title":"J Am Vet Med Assoc","first-page":"673","article-title":"Risk factors associated with acute pancreatitis in dogs: 101 cases (1985-1990)","volume":"203","author":"Cook AK","year":"1993","unstructured":"Cook AK, Breitschwerdt EB, Levine JF, Bunch SE, Linn LO. Risk factors associated with acute pancreatitis in dogs: 101 cases (1985-1990). J Am Vet Med Assoc. 1993;203(5):673-679. doi:10.2460\/javma.1993.203.05.673"},{"issue":"10","key":"ref18","series-title":"Pancreas","first-page":"1263","article-title":"Drug-induced acute pancreatitis in adults: an update","volume":"48","author":"Simons-Linares CR","year":"2019","unstructured":"Simons-Linares CR, Elkhouly MA, Salazar MJ. Drug-induced acute pancreatitis in adults: an update. Pancreas. 2019;48(10):1263-1273. doi:10.1097\/MPA.0000000000001428"},{"issue":"3","key":"ref19","series-title":"J Pharmacol Exp Ther","first-page":"692","article-title":"Intrinsic versus idiosyncratic drug-induced hepatotoxicity-two villains or one?","volume":"332","author":"Roth RA","year":"2010","unstructured":"Roth RA, Ganey PE. Intrinsic versus idiosyncratic drug-induced hepatotoxicity-two villains or one? J Pharmacol Exp Ther. 2010;332(3):692-697. doi:10.1124\/jpet.109.162651"},{"issue":"10","key":"ref20","series-title":"Clin Gastroenterol Hepatol","first-page":"1070","article-title":"Fluid resuscitation in acute pancreatitis","volume":"6","author":"Gardner TB","year":"2008","unstructured":"Gardner TB, Vege SS, Pearson RK, Chari ST. Fluid resuscitation in acute pancreatitis. Clin Gastroenterol Hepatol. 2008;6(10):1070-1076. doi:10.1016\/j.cgh.2008.05.005"},{"issue":"4","key":"ref21","series-title":"Gastroenterology","first-page":"1096","article-title":"American Gastroenterological Association Institute Clinical Guidelines Committee. American gastroenterological association institute clinical guidelines committee. American gastroenterological association institute guideline on initial management of acute pancreatitis","volume":"154","author":"Crockett SD","year":"2018","unstructured":"Crockett SD, Wani S, Gardner TB, ; American Gastroenterological Association Institute Clinical Guidelines Committee. American gastroenterological association institute clinical guidelines committee. American gastroenterological association institute guideline on initial management of acute pancreatitis. Gastroenterology. 2018;154(4):1096-1101. doi:10.1053\/j.gastro.2018.01.032"},{"issue":"8","key":"ref22","series-title":"Pancreatology","first-page":"1405","article-title":"Comprehensive meta-analysis of randomized controlled trials of lactated Ringer\u2019s versus normal saline for acute pancreatitis","volume":"21","author":"Zhou S","year":"2021","unstructured":"Zhou S, Buitrago C, Foong A,  Comprehensive meta-analysis of randomized controlled trials of lactated Ringer\u2019s versus normal saline for acute pancreatitis. Pancreatology. 2021;21(8):1405-1410. doi:10.1016\/j.pan.2021.07.003"},{"issue":"4","key":"ref23","series-title":"Ann R Coll Surg Engl","first-page":"207","article-title":"A multicentre controlled clinical trial of high-volume fresh frozen plasma therapy in prognostically severe acute pancreatitis","volume":"73","author":"Leese T","year":"1991","unstructured":"Leese T, Holliday M, Watkins M,  A multicentre controlled clinical trial of high-volume fresh frozen plasma therapy in prognostically severe acute pancreatitis. Ann R Coll Surg Engl. 1991;73(4):207-214."},{"issue":"5","key":"ref24","series-title":"Arch Surg","first-page":"552","article-title":"A systematic review of the comparative safety of colloids","volume":"139","author":"Barron ME","year":"2004","unstructured":"Barron ME, Wilkes MM, Navickis RJ. A systematic review of the comparative safety of colloids. Arch Surg. 2004;139(5):552-563. doi:10.1001\/archsurg.139.5.552"},{"issue":"11","key":"ref25","series-title":"N Engl J Med","first-page":"989","article-title":"ERICA Consortium. Aggressive or moderate fluid resuscitation in acute pancreatitis","volume":"387","author":"de-Madaria E","year":"2022","unstructured":"de-Madaria E, Buxbaum JL, Maisonneuve P, ; ERICA Consortium. Aggressive or moderate fluid resuscitation in acute pancreatitis. N Engl J Med. 2022;387(11):989-1000. doi:10.1056\/NEJMoa2202884"},{"issue":"5","key":"ref26","series-title":"J Vet Intern Med","first-page":"1794","article-title":"Bile duct obstruction associated with pancreatitis in 46 dogs","volume":"34","author":"Wilkinson AR","year":"2020","unstructured":"Wilkinson AR, DeMonaco SM, Panciera DL, Otoni CC, Leib MS, Larson MM. Bile duct obstruction associated with pancreatitis in 46 dogs. J Vet Intern Med. 2020;34(5):1794-1800. doi:10.1111\/jvim.15879"},{"issue":"3","key":"ref27","series-title":"J Vet Intern Med","first-page":"919","article-title":"Medical and surgical management of pancreatic fluid accumulations in dogs: a retrospective study of 15 cases","volume":"36","author":"Talbot CT","year":"2022","unstructured":"Talbot CT, Cheung R, Holmes EJ, Cook SD. Medical and surgical management of pancreatic fluid accumulations in dogs: a retrospective study of 15 cases. J Vet Intern Med. 2022;36(3):919-926. doi:10.1111\/jvim.16411"},{"issue":"1","key":"ref28","series-title":"J Vet Intern Med","first-page":"79","article-title":"Computed tomographic angiography and ultrasonography in the diagnosis and evaluation of acute pancreatitis in dogs","volume":"33","author":"French JM","year":"2019","unstructured":"French JM, Twedt DC, Rao S, Marolf AJ. Computed tomographic angiography and ultrasonography in the diagnosis and evaluation of acute pancreatitis in dogs. J Vet Intern Med. 2019;33(1):79-88. doi:10.1111\/jvim.15364"},{"issue":"1","key":"ref29","series-title":"J Vet Intern Med","first-page":"28","article-title":"Cardiovascular abnormalities in dogs with acute pancreatitis","volume":"37","author":"Cridge H","year":"2023","unstructured":"Cridge H, Langlois DK, Steiner JM, Sanders RA. Cardiovascular abnormalities in dogs with acute pancreatitis. J Vet Intern Med. 2023;37(1):28-36. doi:10.1111\/jvim.16597"},{"issue":"1","key":"ref30","series-title":"BMC Vet Res","first-page":"209","article-title":"Pulmonary complications in dogs with acute presentation of pancreatitis","volume":"16","author":"Gori E","year":"2020","unstructured":"Gori E, Pierini A, Ceccherini G,  Pulmonary complications in dogs with acute presentation of pancreatitis. BMC Vet Res. 2020;16(1):209. doi:10.1186\/s12917-020-02427-y"},{"issue":"3","key":"ref31","series-title":"J Vet Emerg Crit Care (San Antonio)","first-page":"264","article-title":"Multicenter investigation of hemostatic dysfunction in 15 dogs with acute pancreatitis","volume":"29","author":"Nielsen L","year":"2019","unstructured":"Nielsen L, Holm J, Rozanski E, Meola D, Price LL, de Laforcade A. Multicenter investigation of hemostatic dysfunction in 15 dogs with acute pancreatitis. J Vet Emerg Crit Care (San Antonio). 2019;29(3):264-268. doi:10.1111\/vec.12840"},{"issue":"38","key":"ref32","series-title":"World J Gastroenterol","first-page":"13879","article-title":"Treatment of severe acute pancreatitis and its complications","volume":"20","author":"Zerem E","year":"2014","unstructured":"Zerem E. Treatment of severe acute pancreatitis and its complications. World J Gastroenterol. 2014;20(38):13879-13892. doi:10.3748\/wjg.v20.i38.13879"},{"issue":"5","key":"ref33","series-title":"J Vet Diagn Invest","first-page":"702","article-title":"Effect of pancreatic tissue sampling on serum pancreatic enzyme levels in clinically healthy dogs","volume":"22","author":"Cordner AP","year":"2010","unstructured":"Cordner AP, Armstrong PJ, Newman SJ, Novo R, Sharkey LC, Jessen Emeritus C. Effect of pancreatic tissue sampling on serum pancreatic enzyme levels in clinically healthy dogs. J Vet Diagn Invest. 2010;22(5):702-707. doi:10.1177\/104063871002200505"},{"issue":"2","key":"ref34","series-title":"J Vet Diagn Invest","first-page":"236","article-title":"Cytologic findings and diagnostic yield in 92 dogs undergoing fine-needle aspiration of the pancreas","volume":"27","author":"Cordner AP","year":"2015","unstructured":"Cordner AP, Sharkey LC, Armstrong PJ, McAteer KD. Cytologic findings and diagnostic yield in 92 dogs undergoing fine-needle aspiration of the pancreas. J Vet Diagn Invest. 2015;27(2):236-240. doi:10.1177\/1040638715574862"},{"issue":"7","key":"ref35","series-title":"Intern Emerg Med","first-page":"1905","article-title":"Ileus in acute pancreatitis correlates with severity of pancreatitis, not volume of fluid resuscitation or opioid use: observations from Mid-West cohort","volume":"16","author":"Alam SM","year":"2021","unstructured":"Alam SM, Buaisha H, Qasswal M, Ashfaq MZ, Walters RW, Chandra S. Ileus in acute pancreatitis correlates with severity of pancreatitis, not volume of fluid resuscitation or opioid use: observations from Mid-West cohort. Intern Emerg Med. 2021;16(7):1905-1911. doi:10.1007\/s11739-021-02696-x"},{"issue":"1","key":"ref36","series-title":"Vet Clin North Am Small Anim Pract","first-page":"43","article-title":"Gastric motility disorders in dogs and cats","volume":"51","author":"Husnik R","year":"2021","unstructured":"Husnik R, Gaschen F. Gastric motility disorders in dogs and cats. Vet Clin North Am Small Anim Pract. 2021;51(1):43-59. doi:10.1016\/j.cvsm.2020.09.002"},{"issue":"24","key":"ref37","series-title":"Br J Pharmacol","first-page":"4751","article-title":"Dopamine D2 receptor signalling controls inflammation in acute pancreatitis via a PP2A-dependent Akt\/NF-\u03baB signalling pathway","volume":"174","author":"Han X","year":"2017","unstructured":"Han X, Li B, Ye X,  Dopamine D2 receptor signalling controls inflammation in acute pancreatitis via a PP2A-dependent Akt\/NF-\u03baB signalling pathway. Br J Pharmacol. 2017;174(24):4751-4770. doi:10.1111\/bph.14057"},{"issue":"9","key":"ref38","series-title":"N Engl J Med","first-page":"665","article-title":"Aspiration pneumonitis and aspiration pneumonia","volume":"344","author":"Marik PE","year":"2001","unstructured":"Marik PE. Aspiration pneumonitis and aspiration pneumonia. N Engl J Med. 2001;344(9):665-671. doi:10.1056\/NEJM200103013440908"},{"issue":"20","key":"ref39","series-title":"JAMA","first-page":"2120","article-title":"Acid-suppressive medication use and the risk for hospital-acquired pneumonia","volume":"301","author":"Herzig SJ","year":"2009","unstructured":"Herzig SJ, Howell MD, Ngo LH, Marcantonio ER. Acid-suppressive medication use and the risk for hospital-acquired pneumonia. JAMA. 2009;301(20):2120-2128. doi:10.1001\/jama.2009.722"},{"issue":"1","key":"ref40","series-title":"J Small Anim Pract","first-page":"50","article-title":"Diabetes mellitus and pancreatitis-cause or effect?","volume":"56","author":"Davison LJ","year":"2015","unstructured":"Davison LJ. Diabetes mellitus and pancreatitis-cause or effect? J Small Anim Pract. 2015;56(1):50-59. doi:10.1111\/jsap.12295"},{"issue":"6","key":"ref41","series-title":"J Vet Emerg Crit Care (San Antonio)","first-page":"541","article-title":"Retrospective evaluation of 4 methods for outcome prediction in overt disseminated intravascular coagulation in dogs (2009-2014): 804 cases","volume":"28","author":"Goggs R","year":"2018","unstructured":"Goggs R, Mastrocco A, Brooks MB. Retrospective evaluation of 4 methods for outcome prediction in overt disseminated intravascular coagulation in dogs (2009-2014): 804 cases. J Vet Emerg Crit Care (San Antonio). 2018;28(6):541-550. doi:10.1111\/vec.12777"},{"key":"ref42","series-title":"Vet J","first-page":"77","article-title":"Acute pancreatitis and acute kidney injury in dogs","volume":"245","author":"Gori E","year":"2019","unstructured":"Gori E, Lippi I, Guidi G, Perondi F, Pierini A, Marchetti V. Acute pancreatitis and acute kidney injury in dogs. Vet J. 2019;245:77-81. doi:10.1016\/j.tvjl.2019.01.002"},{"issue":"12","key":"ref43","series-title":"Animals","first-page":"1581","article-title":"Risk factors and clinical presentation in dogs with increased serum pancreatic lipase concentrations\u2014a descriptive analysis","volume":"12","author":"Cridge H","year":"2022","unstructured":"Cridge H, Scott N, Steiner JM. Risk factors and clinical presentation in dogs with increased serum pancreatic lipase concentrations\u2014a descriptive analysis. Animals. 2022;12(12):1581. doi:10.3390\/ani12121581."},{"issue":"1","key":"ref44","series-title":"J Small Anim Pract","first-page":"4","article-title":"Emesis in dogs: a review","volume":"51","author":"Elwood C","year":"2010","unstructured":"Elwood C, Devauchelle P, Elliott J,  Emesis in dogs: a review. J Small Anim Pract. 2010;51(1):4-22. doi:10.1111\/j.1748-5827.2009.00820.x"},{"issue":"3","key":"ref45","series-title":"Top Companion Anim Med","first-page":"123","article-title":"Acute pancreatitis in dogs: advances in understanding, diagnostics, and treatment","volume":"27","author":"Mansfield C","year":"2012","unstructured":"Mansfield C. Acute pancreatitis in dogs: advances in understanding, diagnostics, and treatment. Top Companion Anim Med. 2012;27(3):123-132. doi:10.1053\/j.tcam.2012.04.003"},{"issue":"6","key":"ref46","series-title":"J Vet Pharmacol Ther","first-page":"533","article-title":"Comparative efficacy of maropitant and selected drugs in preventing emesis induced by centrally or peripherally acting emetogens in dogs","volume":"31","author":"Sedlacek HS","year":"2008","unstructured":"Sedlacek HS, Ramsey DS, Boucher JF, Eagleson JS, Conder GA, Clemence RG. Comparative efficacy of maropitant and selected drugs in preventing emesis induced by centrally or peripherally acting emetogens in dogs. J Vet Pharmacol Ther. 2008;31(6):533-537. doi:10.1111\/j.1365-2885.2008.00991.x"},{"issue":"2","key":"ref47","series-title":"J Small Anim Pract","first-page":"93","article-title":"The anti-emetic efficacy of maropitant (Cerenia) in the treatment of ongoing emesis caused by a wide range of underlying clinical aetiologies in canine patients in Europe","volume":"48","author":"de la Puente-Redondo VA","year":"2007","unstructured":"de la Puente-Redondo VA, Siedek EM, Benchaoui HA, Tilt N, Rowan TG, Clemence RG. The anti-emetic efficacy of maropitant (Cerenia) in the treatment of ongoing emesis caused by a wide range of underlying clinical aetiologies in canine patients in Europe. J Small Anim Pract. 2007;48(2):93-98. doi:10.1111\/j.1748-5827.2006.00321.x"},{"issue":"2","key":"ref48","series-title":"Neuroscience","first-page":"345","article-title":"Deficits in visceral pain and hyperalgesia of mice with a disruption of the tachykinin NK1 receptor gene","volume":"98","author":"Laird JM","year":"2000","unstructured":"Laird JM, Olivar T, Roza C, De Felipe C, Hunt SP, Cervero F. Deficits in visceral pain and hyperalgesia of mice with a disruption of the tachykinin NK1 receptor gene. Neuroscience. 2000;98(2):345-352. doi:10.1016\/s0306-4522(00)00148-2"},{"issue":"10","key":"ref49","series-title":"PLoS One","first-page":"e0140734","article-title":"Comparison of NK-1 receptor antagonist (maropitant) to morphine as a pre-anaesthetic agent for canine ovariohysterectomy","volume":"10","author":"Marquez M","year":"2015","unstructured":"Marquez M, Boscan P, Weir H, Vogel P, Twedt DC. Comparison of NK-1 receptor antagonist (maropitant) to morphine as a pre-anaesthetic agent for canine ovariohysterectomy. PLoS One. 2015;10(10):e0140734. doi:10.1371\/journal.pone.0140734"},{"issue":"1","key":"ref50","series-title":"BMC Vet Res","first-page":"222","article-title":"The use of ondansetron for the treatment of nausea in dogs with vestibular syndrome","volume":"17","author":"Foth S","year":"2021","unstructured":"Foth S, Meller S, Kenward H, Elliott J, Pelligand L, Volk HA. The use of ondansetron for the treatment of nausea in dogs with vestibular syndrome. BMC Vet Res. 2021;17(1):222. doi:10.1186\/s12917-021-02931-9"},{"issue":"5","key":"ref51","series-title":"J Vet Intern Med","first-page":"1726","article-title":"Ondansetron in dogs with nausea associated with vestibular disease: a double-blinded, randomized placebo-controlled crossover study","volume":"36","author":"Henze L","year":"2022","unstructured":"Henze L, Foth S, Meller S,  Ondansetron in dogs with nausea associated with vestibular disease: a double-blinded, randomized placebo-controlled crossover study. J Vet Intern Med. 2022;36(5):1726-1732. doi:10.1111\/jvim.16504"},{"issue":"1","key":"ref52","series-title":"Can Vet J","first-page":"35","article-title":"A comparison between maropitant and metoclopramide for the prevention of morphine-induced nausea and vomiting in dogs","volume":"58","author":"Lorenzutti AM","year":"2017","unstructured":"Lorenzutti AM, Mart\u00edn-Flores M, Litterio NJ, Himelfarb MA, Invaldi SH, Zarazaga MP. A comparison between maropitant and metoclopramide for the prevention of morphine-induced nausea and vomiting in dogs. Can Vet J. 2017;58(1):35-38."},{"issue":"6","key":"ref53","series-title":"J Small Anim Pract","first-page":"E10","article-title":"Guidelines for recognition, assessment and treatment of pain: WSAVA Global Pain Council members and co-authors of this document","volume":"55","author":"Mathews K","year":"2014","unstructured":"Mathews K, Kronen PW, Lascelles D, Nolan A, Robertson S, Steagall PV, Wright B, Yamashita K. Guidelines for recognition, assessment and treatment of pain: WSAVA Global Pain Council members and co-authors of this document: J Small Anim Pract. 2014 Jun;55(6):E10-68. doi:10.1111\/jsap.12200. Epub 2014 May 20. PMID: 24841489."},{"issue":"2","key":"ref54","series-title":"Top Companion Anim Med","first-page":"70","article-title":"Analgesia for anesthetized patients","volume":"25","author":"Lemke KA","year":"2010","unstructured":"Lemke KA, Creighton CM. Analgesia for anesthetized patients. Top Companion Anim Med. 2010;25(2):70-82. doi:10.1053\/j.tcam.2009.12.003"},{"issue":"4","key":"ref55","series-title":"Gut","first-page":"600","article-title":"Morphine worsens the severity and prevents pancreatic regeneration in mouse models of acute pancreatitis","volume":"67","author":"Barlass U","year":"2018","unstructured":"Barlass U, Dutta R, Cheema H,  Morphine worsens the severity and prevents pancreatic regeneration in mouse models of acute pancreatitis. Gut. 2018;67(4):600-602."},{"issue":"7","key":"ref56","series-title":"Pancreas","first-page":"858","article-title":"Effect of intravenous fluids and analgesia on dysmotility in patients with acute pancreatitis: a prospective cohort study","volume":"46","author":"Wu LM","year":"2017","unstructured":"Wu LM, Pendharkar SA, Asrani VM, Windsor JA, Petrov MS. Effect of intravenous fluids and analgesia on dysmotility in patients with acute pancreatitis: a prospective cohort study. Pancreas. 2017;46(7):858-866. doi:10.1097\/MPA.0000000000000864"},{"issue":"4","key":"ref57","series-title":"JAMA Netw Open","first-page":"e191827","article-title":"Factors associated with opioid use in patients hospitalized for acute pancreatitis","volume":"2","author":"Wu BU","year":"2019","unstructured":"Wu BU, Butler RK, Chen W. Factors associated with opioid use in patients hospitalized for acute pancreatitis. JAMA Netw Open. 2019;2(4):e191827. doi:10.1001\/jamanetworkopen.2019.1827"},{"issue":"2","key":"ref58","series-title":"Anesth Analg","first-page":"482","article-title":"Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review","volume":"99","author":"Subramaniam K","year":"2004","unstructured":"Subramaniam K, Subramaniam B, Steinbrook RA. Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review. Anesth Analg. 2004;99(2):482-495. doi:10.1213\/01.ANE.0000118109.12855.07"},{"issue":"1","key":"ref59","series-title":"J Am Vet Med Assoc","first-page":"72","article-title":"Use of low doses of ketamine administered by constant rate infusion as an adjunct for postoperative analgesia in dogs","volume":"221","author":"Wagner AE","year":"2002","unstructured":"Wagner AE, Walton JA, Hellyer PW, Gaynor JS, Mama KR. Use of low doses of ketamine administered by constant rate infusion as an adjunct for postoperative analgesia in dogs. J Am Vet Med Assoc. 2002;221(1):72-75. doi:10.2460\/javma.2002.221.72"},{"issue":"9","key":"ref60","series-title":"Am J Vet Res","first-page":"1155","article-title":"Effects of morphine, lidocaine, ketamine, and morphine-lidocaine-ketamine drug combination on minimum alveolar concentration in dogs anesthetized with isoflurane","volume":"64","author":"Muir III WW","year":"2003","unstructured":"Muir III WW, Wiese AJ, March PA. Effects of morphine, lidocaine, ketamine, and morphine-lidocaine-ketamine drug combination on minimum alveolar concentration in dogs anesthetized with isoflurane. Am J Vet Res. 2003;64(9):1155-1160. doi:10.2460\/ajvr.2003.64.1155"},{"issue":"12","key":"ref61","series-title":"Am J Vet Res","first-page":"2122","article-title":"Cardiovascular and respiratory effects of ketamine infusions in isoflurane-anesthetized dogs before and during noxious stimulation","volume":"66","author":"Boscan P","year":"2005","unstructured":"Boscan P, Pypendop BH, Solano AM, Ilkiw JE. Cardiovascular and respiratory effects of ketamine infusions in isoflurane-anesthetized dogs before and during noxious stimulation. Am J Vet Res. 2005;66(12):2122-2129. doi:10.2460\/ajvr.2005.66.2122"},{"issue":"8","key":"ref62","series-title":"Can Vet J","first-page":"856","article-title":"Evaluation of a constant rate infusion of lidocaine for balanced anesthesia in dogs undergoing surgery","volume":"52","author":"Ortega M","year":"2011","unstructured":"Ortega M, Cruz I. Evaluation of a constant rate infusion of lidocaine for balanced anesthesia in dogs undergoing surgery. Can Vet J. 2011;52(8):856-860."},{"issue":"2","key":"ref63","series-title":"J Vet Emerg Crit Care (San Antonio)","first-page":"95","article-title":"Epidural catheter analgesia in dogs and cats: technique and review of 182 cases (1991-1999)","volume":"11","author":"Hansen B","year":"2001","unstructured":"Hansen B. Epidural catheter analgesia in dogs and cats: technique and review of 182 cases (1991-1999). J Vet Emerg Crit Care (San Antonio). 2001;11(2):95-103. doi:10.1111\/j.1476-4431.2001.tb00075.x"},{"issue":"4","key":"ref64","series-title":"Vet Anaesth Analg","first-page":"581","article-title":"Continuous transversus abdominis plane block for analgesia in three dogs with abdominal pain","volume":"45","author":"Freitag FA","year":"2018","unstructured":"Freitag FA, Bozak VL, do Carmo MP, Froes TR, Duque JC. Continuous transversus abdominis plane block for analgesia in three dogs with abdominal pain. Vet Anaesth Analg. 2018;45(4):581-583. doi:10.1016\/j.vaa.2018.02.003"},{"issue":"7","key":"ref65","series-title":"J Am Vet Med Assoc","first-page":"751","article-title":"Clinical evaluation of perioperative administration of gabapentin as an adjunct for postoperative analgesia in dogs undergoing amputation of a forelimb","volume":"236","author":"Wagner AE","year":"2010","unstructured":"Wagner AE, Mich PM, Uhrig SR, Hellyer PW. Clinical evaluation of perioperative administration of gabapentin as an adjunct for postoperative analgesia in dogs undergoing amputation of a forelimb. J Am Vet Med Assoc. 2010;236(7):751-756. doi:10.2460\/javma.236.7.751"},{"issue":"6","key":"ref66","series-title":"Vet Anaesth Analg","first-page":"636","article-title":"Assessment of the effects of adjunctive gabapentin on postoperative pain after intervertebral disc surgery in dogs","volume":"39","author":"Aghighi SA","year":"2012","unstructured":"Aghighi SA, Tipold A, Piechotta M, Lewczuk P, K\u00e4stner SB. Assessment of the effects of adjunctive gabapentin on postoperative pain after intervertebral disc surgery in dogs. Vet Anaesth Analg. 2012;39(6):636-646. doi:10.1111\/j.1467-2995.2012.00769.x"},{"issue":"8","key":"ref67","series-title":"J Vet Med Sci","first-page":"1011","article-title":"Gabapentin as an adjuvant for postoperative pain management in dogs undergoing mastectomy","volume":"77","author":"Crociolli GC","year":"2015","unstructured":"Crociolli GC, Cassu RN, Barbero RC, Rocha TL, Gomes DR, Nic\u00e1cio GM. Gabapentin as an adjuvant for postoperative pain management in dogs undergoing mastectomy. J Vet Med Sci. 2015;77(8):1011-1015. doi:10.1292\/jvms.14-0602"},{"issue":"8","key":"ref68","series-title":"Vet Rec","first-page":"e61","article-title":"Comparing paracetamol\/codeine and meloxicam for postoperative analgesia in dogs: a non-inferiority trial","volume":"187","author":"Pacheco M","year":"2020","unstructured":"Pacheco M, Knowles TG, Hunt J, Slingsby LS, Taylor PM, Murrell JC. Comparing paracetamol\/codeine and meloxicam for postoperative analgesia in dogs: a non-inferiority trial. Vet Rec. 2020;187(8):e61. doi:10.1136\/vr.105487"},{"issue":"4","key":"ref69","series-title":"J Am Vet Med Assoc","first-page":"427","article-title":"Lack of effectiveness of tramadol hydrochloride for the treatment of pain and joint dysfunction in dogs with chronic osteoarthritis","volume":"252","author":"Budsberg SC","year":"2018","unstructured":"Budsberg SC, Torres BT, Kleine SA, Sandberg GS, Berjeski AK. Lack of effectiveness of tramadol hydrochloride for the treatment of pain and joint dysfunction in dogs with chronic osteoarthritis. J Am Vet Med Assoc. 2018;252(4):427-432. doi:10.2460\/javma.252.4.427"},{"key":"ref70","series-title":"Comp Contin Educ Pract","first-page":"13","article-title":"Pancreatitis in dogs and cats: cause, pathogenesis, diagnosis, and treatment","volume":"16","author":"Stewart A","year":"1994","unstructured":"Stewart A. Pancreatitis in dogs and cats: cause, pathogenesis, diagnosis, and treatment. Comp Contin Educ Pract. 1994;16:13-26."},{"issue":"2","key":"ref71","series-title":"Am J Physiol Gastrointest Liver Physiol","first-page":"G181","article-title":"Trypsin secretion and turnover in patients with acute pancreatitis","volume":"289","author":"O\u2019Keefe SJ","year":"2005","unstructured":"O\u2019Keefe SJ, Lee RB, Li J, Stevens S, Abou-Assi S, Zhou W. Trypsin secretion and turnover in patients with acute pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2005;289(2):G181-G187. doi:10.1152\/ajpgi.00297.2004"},{"issue":"4","key":"ref72","series-title":"Gastroenterology","first-page":"1120","article-title":"Pancreatic exocrine secretion in acute experimental pancreatitis","volume":"99","author":"Niederau C","year":"1990","unstructured":"Niederau C, Niederau M, L\u00fcthen R, Strohmeyer G, Ferrell LD, Grendell JH. Pancreatic exocrine secretion in acute experimental pancreatitis. Gastroenterology. 1990;99(4):1120-1127. doi:10.1016\/0016-5085(90)90633-c"},{"issue":"4","key":"ref73","series-title":"Pancreatology","first-page":"303","article-title":"A prospective evaluation of pancreatic exocrine function in patients with acute pancreatitis: correlation with extent of necrosis and pancreatic endocrine insufficiency","volume":"3","author":"Boreham B","year":"2003","unstructured":"Boreham B, Ammori BJ. A prospective evaluation of pancreatic exocrine function in patients with acute pancreatitis: correlation with extent of necrosis and pancreatic endocrine insufficiency. Pancreatology. 2003;3(4):303-308. doi:10.1159\/000071768"},{"issue":"3","key":"ref74","series-title":"Arch Surg","first-page":"287","article-title":"Enteral nutrition prevents bacterial translocation but does not improve survival during acute pancreatitis","volume":"134","author":"Kotani J","year":"1999","unstructured":"Kotani J, Usami M, Nomura H,  Enteral nutrition prevents bacterial translocation but does not improve survival during acute pancreatitis. Arch Surg. 1999;134(3):287-292. doi:10.1001\/archsurg.134.3.287"},{"issue":"1","key":"ref75","series-title":"Hepatobiliary Pancreat Dis Int","first-page":"150","article-title":"Early intrajejunal nutrition: bacterial translocation and gut barrier function of severe acute pancreatitis in dogs","volume":"1","author":"Qin HL","year":"2002","unstructured":"Qin HL, Su ZD, Gao Q, Lin QT. Early intrajejunal nutrition: bacterial translocation and gut barrier function of severe acute pancreatitis in dogs. Hepatobiliary Pancreat Dis Int. 2002;1(1):150-154."},{"issue":"3","key":"ref76","series-title":"J Vet Intern Med","first-page":"419","article-title":"A pilot study to assess tolerability of early enteral nutrition via esophagostomy tube feeding in dogs with severe acute pancreatitis","volume":"25","author":"Mansfield CS","year":"2011","unstructured":"Mansfield CS, James FE, Steiner JM, Suchodolski JS, Robertson ID, Hosgood G. A pilot study to assess tolerability of early enteral nutrition via esophagostomy tube feeding in dogs with severe acute pancreatitis. J Vet Intern Med. 2011;25(3):419-425. doi:10.1111\/j.1939-1676.2011.0703.x"},{"issue":"4","key":"ref77","series-title":"J Vet Emerg Crit Care (San Antonio)","first-page":"425","article-title":"Retrospective evaluation of the impact of early enteral nutrition on clinical outcomes in dogs with pancreatitis: 34 cases (2010-2013)","volume":"27","author":"Harris JP","year":"2017","unstructured":"Harris JP, Parnell NK, Griffith EH, Saker KE. Retrospective evaluation of the impact of early enteral nutrition on clinical outcomes in dogs with pancreatitis: 34 cases (2010-2013). J Vet Emerg Crit Care (San Antonio). 2017;27(4):425-433. doi:10.1111\/vec.12612"},{"issue":"6","key":"ref78","series-title":"J Vet Intern Med","first-page":"2315","article-title":"Tolerability of naso-esophageal feeding tubes in dogs and cats at home: retrospective review of 119 cases","volume":"37","author":"Dumont R","year":"2023","unstructured":"Dumont R, Lemetayer J, Desquilbet L, Darnis E. Tolerability of naso-esophageal feeding tubes in dogs and cats at home: retrospective review of 119 cases. J Vet Intern Med. 2023;37(6):2315-2321. doi:10.1111\/jvim.16732"},{"key":"ref79","series-title":"J Vet Intern Med","first-page":"421","article-title":"Results of a ketogenic food trial for dogs with idiopathic epilepsy","volume":"19","author":"Patterson E","year":"2005","unstructured":"Patterson E, Munana K, Kirk C. Results of a ketogenic food trial for dogs with idiopathic epilepsy. J Vet Intern Med. 2005;19:421."},{"issue":"5","key":"ref80","series-title":"J Vet Intern Med","first-page":"2287","article-title":"Efficacy of medical dissolution for suspected struvite cystoliths in dogs","volume":"35","author":"Wingert AM","year":"2021","unstructured":"Wingert AM, Murray OA, Lulich JP, Hoelmer AM, Merkel LK, Furrow E. Efficacy of medical dissolution for suspected struvite cystoliths in dogs. J Vet Intern Med. 2021;35(5):2287-2295. doi:10.1111\/jvim.16252"},{"issue":"6 pt 1","key":"ref81","series-title":"Am J Physiol","first-page":"G662","article-title":"Canine gastric emptying of fiber meals: influence of meal viscosity and antroduodenal motility","volume":"249","author":"Russell J","year":"1985","unstructured":"Russell J, Bass P. Canine gastric emptying of fiber meals: influence of meal viscosity and antroduodenal motility. Am J Physiol. 1985;249(6 pt 1):G662-G667."},{"key":"ref82","series-title":"Clin Res Hepatol Gastroenterol","first-page":"100002","article-title":"A systematic review of NSAIDs treatment for acute pancreatitis in animal studies and clinical trials","volume":"44S","author":"Wu D","year":"2020","unstructured":"Wu D, Bai X, Lee P, Yang Y, Windsor J, Qian J. A systematic review of NSAIDs treatment for acute pancreatitis in animal studies and clinical trials. Clin Res Hepatol Gastroenterol. 2020;44S:100002. doi:10.1016\/j.clirex.2019.100002"},{"issue":"2","key":"ref83","series-title":"Dig Dis","first-page":"113","article-title":"Drug-induced acute pancreatitis: further criticism","volume":"11","author":"Frick TW","year":"1993","unstructured":"Frick TW, Speiser DE, Bimmler D, Largiad\u00e8r F. Drug-induced acute pancreatitis: further criticism. Dig Dis. 1993;11(2):113-132. doi:10.1159\/000171405"},{"issue":"2","key":"ref84","series-title":"Vet Clin North Am Small Anim Pract","first-page":"289","article-title":"Toxicology of frequently encountered nonsteroidal anti-inflammatory drugs in dogs and cats","volume":"42","author":"Khan SA","year":"2012","unstructured":"Khan SA, McLean MK. Toxicology of frequently encountered nonsteroidal anti-inflammatory drugs in dogs and cats. Vet Clin North Am Small Anim Pract. 2012;42(2):289-306, vi-vii. doi:10.1016\/j.cvsm.2012.01.003"},{"issue":"01","key":"ref85","series-title":"Tierarztl Prax Ausg K Kleintiere Heimtiere","first-page":"19","article-title":"Schmerztherapie mit Metamizol","volume":"36","author":"Tacke S","year":"2008","unstructured":"Tacke S, Henke J, Erhardt W. Schmerztherapie mit Metamizol. Tierarztl Prax Ausg K Kleintiere Heimtiere. 2008;36(01):19-25. doi:10.1055\/s-0038-1622655"},{"issue":"5","key":"ref86","series-title":"J Small Anim Pract","first-page":"298","article-title":"Comparison of initial treatment with and without corticosteroids for suspected acute pancreatitis in dogs","volume":"60","author":"Okanishi H","year":"2019","unstructured":"Okanishi H, Nagata T, Nakane S, Watari T. Comparison of initial treatment with and without corticosteroids for suspected acute pancreatitis in dogs. J Small Anim Pract. 2019;60(5):298-304. doi:10.1111\/jsap.12994"},{"key":"ref87","series-title":"Vet J","first-page":"105677","article-title":"Critical illness-related corticosteroid insufficiency in dogs with systemic inflammatory response syndrome: a pilot study in 21 dogs","volume":"273","author":"Marchetti M","year":"2021","unstructured":"Marchetti M, Pierini A, Favilla G, Marchetti V. Critical illness-related corticosteroid insufficiency in dogs with systemic inflammatory response syndrome: a pilot study in 21 dogs. Vet J. 2021;273:105677. doi:10.1016\/j.tvjl.2021.105677"},{"issue":"8","key":"ref88","series-title":"Clin Exp Med","first-page":"4107","article-title":"Recent advances in the role of neutrophils and neutrophil extracellular traps in acute pancreatitis","volume":"23","author":"Ishqi HM","year":"2023","unstructured":"Ishqi HM, Ali M, Dawra R. Recent advances in the role of neutrophils and neutrophil extracellular traps in acute pancreatitis. Clin Exp Med. 2023;23(8):4107-4122. doi:10.1007\/s10238-023-01180-4"},{"key":"ref89","series-title":"Front Cell Dev Biol","first-page":"565758","article-title":"The role of neutrophils and neutrophil extracellular traps in acute pancreatitis","volume":"8","author":"Wan J","year":"2021","unstructured":"Wan J, Ren Y, Yang X, Li X, Xia L, Lu N. The role of neutrophils and neutrophil extracellular traps in acute pancreatitis. Front Cell Dev Biol. 2021;8:565758. doi:10.3389\/fcell.2020.565758"},{"issue":"4","key":"ref90","series-title":"Biomed J","first-page":"439","article-title":"Understanding the role of neutrophils in acute respiratory distress syndrome","volume":"44","author":"Yang SC","year":"2021","unstructured":"Yang SC, Tsai YF, Pan YL, Hwang TL. Understanding the role of neutrophils in acute respiratory distress syndrome. Biomed J. 2021;44(4):439-446. doi:10.1016\/j.bj.2020.09.001"},{"issue":"1","key":"ref91","series-title":"Res Vet Sci","first-page":"83","article-title":"Levels of total alpha-macroglobulin and trypsin-like immunoreactivity are poor indicators of clinical severity in spontaneous canine acute pancreatitis","volume":"67","author":"Ruaux CG","year":"1999","unstructured":"Ruaux CG, Atwell RB. Levels of total alpha-macroglobulin and trypsin-like immunoreactivity are poor indicators of clinical severity in spontaneous canine acute pancreatitis. Res Vet Sci. 1999;67(1):83-87. doi:10.1053\/rvsc.1998.0294"},{"issue":"12","key":"ref92","series-title":"Aust Vet J","first-page":"804","article-title":"A severity score for spontaneous canine acute pancreatitis","volume":"76","author":"Ruaux CG","year":"1998","unstructured":"Ruaux CG, Atwell RB. A severity score for spontaneous canine acute pancreatitis. Aust Vet J. 1998;76(12):804-808. doi:10.1111\/j.1751-0813.1998.tb12331.x"},{"issue":"6","key":"ref93","series-title":"J Am Vet Med Assoc","first-page":"936","article-title":"Development of a clinical severity index for dogs with acute pancreatitis","volume":"233","author":"Mansfield CS","year":"2008","unstructured":"Mansfield CS, James FE, Robertson ID. Development of a clinical severity index for dogs with acute pancreatitis. J Am Vet Med Assoc. 2008;233(6):936-944. doi:10.2460\/javma.233.6.936"},{"issue":"5","key":"ref94","series-title":"J Vet Intern Med","first-page":"2187","article-title":"Serum concentrations of canine pancreatic lipase immunoreactivity and C-reactive protein for monitoring disease progression in dogs with acute pancreatitis","volume":"35","author":"Keany KM","year":"2021","unstructured":"Keany KM, Fosgate GT, Perry SM, Stroup ST, Steiner JM. Serum concentrations of canine pancreatic lipase immunoreactivity and C-reactive protein for monitoring disease progression in dogs with acute pancreatitis. J Vet Intern Med. 2021;35(5):2187-2195. doi:10.1111\/jvim.16218"},{"issue":"20","key":"ref95","series-title":"Vet Rec","first-page":"519","article-title":"Acute haemorrhagic pancreatitis associated with canine visceral leishmaniasis","volume":"141","author":"Carrasco L","year":"1997","unstructured":"Carrasco L, de Lara FC, Martin E,  Acute haemorrhagic pancreatitis associated with canine visceral leishmaniasis. Vet Rec. 1997;141(20):519-521. doi:10.1136\/vr.141.20.519"},{"issue":"4","key":"ref96","series-title":"J S Afr Vet Assoc","first-page":"232","article-title":"Acute pancreatitis: a newly recognised potential complication of canine babesiosis","volume":"71","author":"M\u00f6hr AJ","year":"2000","unstructured":"M\u00f6hr AJ, Lobetti RG, van der Lugt JJ. Acute pancreatitis: a newly recognised potential complication of canine babesiosis. J S Afr Vet Assoc. 2000;71(4):232-239. doi:10.4102\/jsava.v71i4.721"},{"issue":"2","key":"ref97","series-title":"J Am Vet Med Assoc","first-page":"193","article-title":"Heterobilharzia americana infection in a dog","volume":"220","author":"Flowers JR","year":"2002","unstructured":"Flowers JR, Hammerberg B, Wood SL,  Heterobilharzia americana infection in a dog. J Am Vet Med Assoc. 2002;220(2):193-196. doi:10.2460\/javma.2002.220.193"},{"issue":"5","key":"ref98","series-title":"Vet Radiol Ultrasound","first-page":"538","article-title":"Imaging diagnosis\u2014Heterobilharzia americana infection in a dog","volume":"52","author":"Kvitko-White HL","year":"2011","unstructured":"Kvitko-White HL, Sayre RS, Corapi WV, Spaulding KA. Imaging diagnosis\u2014Heterobilharzia americana infection in a dog. Vet Radiol Ultrasound. 2011;52(5):538-541. doi:10.1111\/j.1740-8261.2011.01831.x"},{"issue":"4","key":"ref99","series-title":"J Vet Diagn Invest","first-page":"826","article-title":"Multi-organ involvement of Heterobilharzia americana infection in a dog presented for systemic mineralization","volume":"23","author":"Corapi WV","year":"2011","unstructured":"Corapi WV, Ajithdoss DK, Snowden KF, Spaulding KA. Multi-organ involvement of Heterobilharzia americana infection in a dog presented for systemic mineralization. J Vet Diagn Invest. 2011;23(4):826-831. doi:10.1177\/1040638711407894"},{"issue":"1","key":"ref100","series-title":"Pancreas","first-page":"18","article-title":"The early increase in intestinal permeability and systemic endotoxin exposure in patients with severe acute pancreatitis is not associated with systemic bacterial translocation: molecular investigation of microbial DNA in the blood","volume":"26","author":"Ammori BJ","year":"2003","unstructured":"Ammori BJ, Fitzgerald P, Hawkey P, McMahon MJ. The early increase in intestinal permeability and systemic endotoxin exposure in patients with severe acute pancreatitis is not associated with systemic bacterial translocation: molecular investigation of microbial DNA in the blood. Pancreas. 2003;26(1):18-22. doi:10.1097\/00006676-200301000-00004"},{"issue":"4","key":"ref101","series-title":"Gastroenterol Clin Biol","first-page":"431","article-title":"Infectious complications, prognostic factors and assessment of anti-infectious management of 212 consecutive patients with acute pancreatitis","volume":"31","author":"Bourgaux JF","year":"2007","unstructured":"Bourgaux JF, Defez C, Muller L,  Infectious complications, prognostic factors and assessment of anti-infectious management of 212 consecutive patients with acute pancreatitis. Gastroenterol Clin Biol. 2007;31(4):431-435. doi:10.1016\/s0399-8320(07)89406-1"},{"issue":"6","key":"ref102","series-title":"Am J Surg","first-page":"806","article-title":"Antibiotic prophylaxis is not protective in severe acute pancreatitis: a systematic review and meta-analysis","volume":"197","author":"Jafri NS","year":"2009","unstructured":"Jafri NS, Mahid SS, Idstein SR, Hornung CA, Galandiuk S. Antibiotic prophylaxis is not protective in severe acute pancreatitis: a systematic review and meta-analysis. Am J Surg. 2009;197(6):806-813. doi:10.1016\/j.amjsurg.2008.08.016"},{"issue":"6","key":"ref103","series-title":"Lancet Infect Dis","first-page":"374","article-title":"Efficacy of probiotics in prevention of acute diarrhoea: a meta-analysis of masked, randomised, placebo-controlled trials","volume":"6","author":"Sazawal S","year":"2006","unstructured":"Sazawal S, Hiremath G, Dhingra U, Malik P, Deb S, Black RE. Efficacy of probiotics in prevention of acute diarrhoea: a meta-analysis of masked, randomised, placebo-controlled trials. Lancet Infect Dis. 2006;6(6):374-382. doi:10.1016\/S1473-3099(06)70495-9"},{"issue":"10","key":"ref104","series-title":"Scand J Gastroenterol","first-page":"1249","article-title":"Prophylactic antibiotic treatment in acute necrotizing pancreatitis: results from a meta-analysis","volume":"43","author":"Xu T","year":"2008","unstructured":"Xu T, Cai Q. Prophylactic antibiotic treatment in acute necrotizing pancreatitis: results from a meta-analysis. Scand J Gastroenterol. 2008;43(10):1249-1258. doi:10.1080\/00365520802130175"},{"issue":"3","key":"ref105","series-title":"Scand J Gastroenterol","first-page":"261","article-title":"Systematic review and meta-analysis of antibiotic prophylaxis in severe acute pancreatitis","volume":"46","author":"Wittau M","year":"2011","unstructured":"Wittau M, Mayer B, Scheele J, Henne-Bruns D, Dellinger EP, Isenmann R. Systematic review and meta-analysis of antibiotic prophylaxis in severe acute pancreatitis. Scand J Gastroenterol. 2011;46(3):261-270. doi:10.3109\/00365521.2010.531486"},{"issue":"4","key":"ref106","series-title":"J Am Anim Hosp Assoc","first-page":"171","article-title":"Pancreatic abscess in 36 dogs: a retrospective analysis of prognostic indicators","volume":"44","author":"Anderson JR","year":"2008","unstructured":"Anderson JR, Cornell KK, Parnell NK, Salisbury SK. Pancreatic abscess in 36 dogs: a retrospective analysis of prognostic indicators. J Am Anim Hosp Assoc. 2008;44(4):171-179. doi:10.5326\/0440171"},{"issue":"6","key":"ref107","series-title":"J Vet Intern Med","first-page":"1823","article-title":"ACVIM consensus statement: support for rational administration of gastrointestinal protectants to dogs and cats","volume":"32","author":"Marks SL","year":"2018","unstructured":"Marks SL, Kook PH, Papich MG, Tolbert MK, Willard MD. ACVIM consensus statement: support for rational administration of gastrointestinal protectants to dogs and cats. J Vet Intern Med. 2018;32(6):1823-1840. doi:10.1111\/jvim.15337"},{"issue":"3","key":"ref108","series-title":"Am J Vet Res","first-page":"425","article-title":"Effects of ranitidine, famotidine, pantoprazole, and omeprazole on intragastric pH in dogs","volume":"66","author":"Bersenas AM","year":"2005","unstructured":"Bersenas AM, Mathews KA, Allen DG, Conlon PD. Effects of ranitidine, famotidine, pantoprazole, and omeprazole on intragastric pH in dogs. Am J Vet Res. 2005;66(3):425-431. doi:10.2460\/ajvr.2005.66.425"},{"issue":"5","key":"ref109","series-title":"J Vet Intern Med","first-page":"1988","article-title":"Evaluation of the effect of a famotidine continuous rate infusion on intragastric pH in healthy dogs","volume":"33","author":"Hedges K","year":"2019","unstructured":"Hedges K, Odunayo A, Price JM, Hecht S, Tolbert MK. Evaluation of the effect of a famotidine continuous rate infusion on intragastric pH in healthy dogs. J Vet Intern Med. 2019;33(5):1988-1994. doi:10.1111\/jvim.15558"},{"issue":"5","key":"ref110","series-title":"Hoppe Seylers Z Physiol Chem","first-page":"651","article-title":"Trasylol prevents trypsin-induced shock in dogs","volume":"360","author":"Balldin G","year":"1979","unstructured":"Balldin G, Ohlsson K. Trasylol prevents trypsin-induced shock in dogs. Hoppe Seylers Z Physiol Chem. 1979;360(5):651-656. doi:10.1515\/bchm2.1979.360.1.651"},{"issue":"3","key":"ref111","series-title":"Br J Surg","first-page":"177","article-title":"A controlled trial of Trasylol in the treatment of acute pancreatitis","volume":"61","author":"Trapnell JE","year":"1974","unstructured":"Trapnell JE, Rigby CC, Talbot CH, Duncan EHL. A controlled trial of Trasylol in the treatment of acute pancreatitis. Br J Surg. 1974;61(3):177-182. doi:10.1002\/bjs.1800610303"},{"issue":"1","key":"ref112","series-title":"Digestion","first-page":"32","article-title":"Effective aprotinin therapy in canine experimental bile-trypsin pancreatitis","volume":"22","author":"Imrie CW","year":"1981","unstructured":"Imrie CW, Mackenzie M. Effective aprotinin therapy in canine experimental bile-trypsin pancreatitis. 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