{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:04:54Z","timestamp":1788199494937,"version":"build-2803163510"},"reference-count":30,"publisher":"American Veterinary Medical Association (AVMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To investigate parasiticide use and describe signalment features in patients with sudden acquired retinal degeneration syndrome (SARDS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>ANIMALS<\/jats:title>\n                    <jats:p>Retrospective case-control study of dogs with (n = 71) and without (136) SARDS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Parasiticide use, presentation season, weight, body condition, and signalment were compared between dogs diagnosed with SARDS and the reference population by use of descriptive statistics and logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Animals with SARDS were at a 5.99 times higher odds of having previously used imidacloprid (95% CI, 1.6 to 22.2;\n                      <jats:italic>P<\/jats:italic>\n                      = .003). However, time of last imidocloprid administration was &gt; 6 years prior to diagnosis in 6 SARDS-affected individuals and 15, 26, or 42 months before diagnosis (n = 1 each). No other class of parasiticide had a significant association with SARDS. Seasonal variation was observed with a negative association identified between incidence of SARDS and tick season (October to January;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001). Overweight and obese dogs were 4.42 (95% CI, 1.9 to 10.4) and 4.96 (95% CI, 2.1 to 11.6) times more likely to have SARDS (\n                      <jats:italic>P<\/jats:italic>\n                      \u2264 .001). History of polyphagia or weight gain was not associated with an increased likelihood of being overweight or obese within the SARDS-affected population (\n                      <jats:italic>P<\/jats:italic>\n                      &gt; .108).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CLINICAL RELEVANCE<\/jats:title>\n                    <jats:p>While a statistically significant association was found between imidacloprid use and SARDS, this is unlikely to be clinically significant given the lack of a temporal association, sparse exposure numbers, and low point estimate of the OR. A positive association between being overweight or obese and a diagnosis of SARDS was found independent of polyphagia and weight gain, suggesting that it may be a risk factor for the development of SARDS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/javma.24.02.0140","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T13:38:31Z","timestamp":1726234711000},"page":"1-6","source":"Crossref","is-referenced-by-count":6,"title":["Parasiticide use and obesity in dogs with sudden acquired retinal degeneration syndrome"],"prefix":"10.2460","volume":"262","author":[{"given":"Paul M. G.","family":"McCarthy","sequence":"first","affiliation":[{"name":"Eye Clinic for Animals, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron J.","family":"Whittaker","sequence":"additional","affiliation":[{"name":"Eye Clinic for Animals, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew J.","family":"Annear","sequence":"additional","affiliation":[{"name":"Eye Clinic for Animals, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Hall","sequence":"additional","affiliation":[{"name":"University of Sydney, Camden, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negar","family":"Hamzianpour","sequence":"additional","affiliation":[{"name":"Eye Clinic for Animals, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Irving","sequence":"additional","affiliation":[{"name":"Eye Clinic for Animals, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin D.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Eye Clinic for Animals, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S.","family":"Smith","sequence":"additional","affiliation":[{"name":"Eye Clinic for Animals, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara M.","family":"Thomasy","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA"},{"name":"Department of Ophthalmology and Vision Science, School of Medicine, University of California-Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly A.","family":"Caruso","sequence":"additional","affiliation":[{"name":"Eye Clinic for Animals, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"4","key":"ref1","series-title":"Vet Ophthalmol","first-page":"319","article-title":"Sudden acquired retinal degeneration syndrome (SARDS) - a review and proposed strategies toward a better understanding of pathogenesis, early diagnosis, and therapy","volume":"19","author":"Kom\u00e1romy AM","year":"2016","unstructured":"Kom\u00e1romy AM, Abrams KL, Heckenlively JR,  Sudden acquired retinal degeneration syndrome (SARDS) - a review and proposed strategies toward a better understanding of pathogenesis, early diagnosis, and therapy. 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