{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:19:41Z","timestamp":1777385981672,"version":"3.51.4"},"reference-count":35,"publisher":"American Veterinary Medical Association (AVMA)","issue":"S2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To evaluate the long-term efficacy, prognostic factors, and complications of intravitreal cidofovir injection in dogs with end-stage glaucoma.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>130 client-owned dogs.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>Medical records of dogs that underwent intravitreal cidofovir injections were reviewed. A minimum follow-up period of 6 months was required as the inclusion criterion. Signalment, type of glaucoma, preinjection intraocular pressure (IOP), types of applied glaucoma eye drop, coexisting ocular diseases, outcomes, and complications were recorded. Success was defined as IOP of \u2264 25 mm Hg at the 2-week recheck that remained to the 6-month recheck.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>The overall success rate of intravitreal cidofovir injection was 91.5% (140\/153). The success rate of a single injection was 69.3% (106\/153), of a second injection was 59.5% (25\/42), of a third injection was 42.9% (6\/14), of a fourth injection was 33.3% (2\/6), and of a fifth injection was 50.0% (1\/2). Intraocular pressures at 6 months after injection were relatively higher when the injection was repeated, fewer types of glaucoma eye drop were applied prior to the injection, and cataract stages were advanced at the time of injection (<jats:italic>P<\/jats:italic> &lt; .05). The most common complications were phthisis bulbi (42.5%), cataract progression (30.1%), and intraocular hemorrhage (16.3%). Six eyes were enucleated, and 3 were enucleated due to corneal perforation.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Intravitreal cidofovir injection had a high long-term success rate in lowering IOP in dogs with end-stage glaucoma.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.24.03.0199","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T14:13:18Z","timestamp":1717769598000},"page":"S32-S39","source":"Crossref","is-referenced-by-count":1,"title":["The effect of intravitreal cidofovir injection on end-stage glaucoma in dogs: a retrospective study of 153 eyes"],"prefix":"10.2460","volume":"262","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4282-2884","authenticated-orcid":true,"given":"Hyelin","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Gwanak-gu, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seonmi","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Gwanak-gu, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dajeong","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Gwanak-gu, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyeong","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Gwanak-gu, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6645-7116","authenticated-orcid":true,"given":"Kangmoon","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Gwanak-gu, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Slatter\u2019s Fundamentals of Veterinary Ophthalmology","first-page":"213","article-title":"The glaucomas","author":"Miller PE","year":"2018","unstructured":"Miller PE. The glaucomas. In: Maggs DJ, Miller PE, Ofri R, eds. Slatter\u2019s Fundamentals of Veterinary Ophthalmology. 6th ed. Elsevier Saunders; 2018:213-253."},{"key":"ref2","series-title":"Veterinary Ophthalmology","first-page":"1173","article-title":"Canine glaucomas","author":"Plummer CE","year":"2021","unstructured":"Plummer CE, Kom\u00e1romy AM, Gelatt KN. Canine glaucomas. In: Gelatt KN, ed. Veterinary Ophthalmology. 6th ed. Wiley Blackwell; 2021:1173."},{"issue":"2","key":"ref3","series-title":"Vet Ophthalmol","first-page":"97","article-title":"Prevalence of the breed-related glaucomas in pure-bred dogs in North America","volume":"7","author":"Gelatt KN","year":"2004","unstructured":"Gelatt KN, MacKay EO. Prevalence of the breed-related glaucomas in pure-bred dogs in North America. Vet Ophthalmol. 2004;7(2):97-111. doi:10.1111\/j.1463-5224.2004.04006.x"},{"issue":"4","key":"ref4","series-title":"Vet Ophthalmol","first-page":"245","article-title":"Secondary glaucomas in the dog in North America","volume":"7","author":"Gelatt KN","year":"2004","unstructured":"Gelatt KN, MacKay EO. Secondary glaucomas in the dog in North America. Vet Ophthalmol. 2004;7(4):245-259. doi:10.1111\/j.1463-5224.2004.04034.x"},{"issue":"5","key":"ref5","series-title":"Vet Ophthalmol","first-page":"726","article-title":"The future of canine glaucoma therapy","volume":"22","author":"Kom\u00e1romy AM","year":"2019","unstructured":"Kom\u00e1romy AM, Bras D, Esson DW,  The future of canine glaucoma therapy. Vet Ophthalmol. 2019;22(5):726-740. doi:10.1111\/vop.12678"},{"key":"ref6","series-title":"Slatter\u2019s Fundamentals of Veterinary Ophthalmology","first-page":"51","article-title":"Ophthalmic medications and therapeutics","author":"Maggs DJ","year":"2018","unstructured":"Maggs DJ. Ophthalmic medications and therapeutics. In: Maggs DJ, Miller PE, Ofri R, eds. Slatter\u2019s Fundamentals of Veterinary Ophthalmology. 6th ed. Elsevier Saunders; 2018:51-84."},{"issue":"suppl 1","key":"ref7","series-title":"Vet Ophthalmol","first-page":"125","article-title":"Pharmacologic ciliary body ablation for chronic glaucoma in dogs: a retrospective review of 108 eyes from 2013 to 2018","volume":"24","author":"Julien ME","year":"2021","unstructured":"Julien ME, Schechtmann SA, Michau TM, Welihozkiy A, Baldwin TL, Stine JM. Pharmacologic ciliary body ablation for chronic glaucoma in dogs: a retrospective review of 108 eyes from 2013 to 2018. Vet Ophthalmol. 2021;24(suppl 1):125-130. doi:10.1111\/vop.12816"},{"issue":"3","key":"ref8","series-title":"Vet Ophthalmol","first-page":"201","article-title":"Intravitreal cidofovir injection for the management of chronic glaucoma in dogs","volume":"17","author":"Low MC","year":"2014","unstructured":"Low MC, Landis ML, Peiffer RL. Intravitreal cidofovir injection for the management of chronic glaucoma in dogs. Vet Ophthalmol. 2014;17(3):201-206. doi:10.1111\/vop.12071"},{"issue":"1","key":"ref9","series-title":"Vet Ophthalmol","first-page":"57","article-title":"Measurement of plasma gentamicin concentrations postchemical ciliary body ablation in dogs with chronic glaucoma","volume":"19","author":"Rankin AJ","year":"2016","unstructured":"Rankin AJ, Lanuza R, KuKanich B,  Measurement of plasma gentamicin concentrations postchemical ciliary body ablation in dogs with chronic glaucoma. Vet Ophthalmol. 2016;19(1):57-62. doi:10.1111\/vop.12258"},{"issue":"6","key":"ref10","series-title":"Arch Ophthalmol","first-page":"733","article-title":"Iritis and hypotony after treatment with intravenous cidofovir for cytomegalovirus retinitis","volume":"115","author":"Davis JL","year":"1997","unstructured":"Davis JL, Taskintuna I, Freeman WR, Weinberg DV, Feuer WJ, Leonard RE. Iritis and hypotony after treatment with intravenous cidofovir for cytomegalovirus retinitis. Arch Ophthalmol. 1997;115(6):733-737. doi:10.1001\/archopht.1997.01100150735008"},{"issue":"5","key":"ref11","series-title":"Exp Eye Res","first-page":"795","article-title":"An animal model for cidofovir (HPMPC) toxicity: intraocular pressure and histopathologic effects","volume":"64","author":"Taskintuna I","year":"1997","unstructured":"Taskintuna I, Banker AS, Rao NA,  An animal model for cidofovir (HPMPC) toxicity: intraocular pressure and histopathologic effects. Exp Eye Res. 1997;64(5):795-806. doi:10.1006\/exer.1996.0273"},{"key":"ref12","series-title":"Veterinary Ophthalmology","first-page":"370","article-title":"Clinical pharmacology and therapeutics","author":"Regnier A","year":"2021","unstructured":"Regnier A. Clinical pharmacology and therapeutics. In: Gelatt KN, ed. Veterinary Ophthalmology. 6th ed. Wiley Blackwell; 2021:370."},{"issue":"5","key":"ref13","series-title":"J Vet Clin","first-page":"341","article-title":"Retinal function analysis and histopathologic assessment after intravitreal cidofovir injection in normal Beagle dogs","volume":"34","author":"Park S","year":"2017","unstructured":"Park S, Kang S, Park S, Han J, Kim Y, Seo K. Retinal function analysis and histopathologic assessment after intravitreal cidofovir injection in normal Beagle dogs. J Vet Clin. 2017;34(5):341-346. doi:10.17555\/jvc.2017.10.34.5.341"},{"issue":"6","key":"ref14","series-title":"Semin Ophthalmol","first-page":"788","article-title":"Phthisis bulbi\u2014a clinico-pathological perspective","volume":"33","author":"Tripathy K","year":"2018","unstructured":"Tripathy K, Chawla R, Temkar S,  Phthisis bulbi\u2014a clinico-pathological perspective. Semin Ophthalmol. 2018;33(6):788-803. doi:10.1080\/08820538.2018.1477966"},{"issue":"3","key":"ref15","series-title":"Rev Med Virol","first-page":"145","article-title":"Clinical uses of cidofovir","volume":"7","author":"Safrin S","year":"1997","unstructured":"Safrin S, Cherrington J, Jaffe HS. Clinical uses of cidofovir. Rev Med Virol. 1997;7(3):145-156. doi:10.1002\/(SICI)1099-1654(199709)7:3<145::AID-RMV196>3.0.CO;2-0"},{"issue":"6","key":"ref16","series-title":"Vet Pathol","first-page":"549","article-title":"The pathology of lens-induced uveitis in dogs","volume":"24","author":"Wilcock BP","year":"1987","unstructured":"Wilcock BP, Peiffer RL Jr. The pathology of lens-induced uveitis in dogs. Vet Pathol. 1987;24(6):549-553. doi:10.1177\/030098588702400613"},{"issue":"5","key":"ref17","series-title":"Invest Ophthalmol Vis Sci","first-page":"593","article-title":"Intravitreal injection of gentamicin in rabbits: effect of inflammation and pigmentation on half-life and ocular distribution","volume":"20","author":"Kane A","year":"1981","unstructured":"Kane A, Barza M, Baum J. Intravitreal injection of gentamicin in rabbits: effect of inflammation and pigmentation on half-life and ocular distribution. Invest Ophthalmol Vis Sci. 1981;20(5):593-597."},{"issue":"6","key":"ref18","series-title":"Invest Ophthalmol Vis Sci","first-page":"1055","article-title":"Pharmacokinetics of intravitreal injection: assessment of a gentamicin model by ocular dialysis","volume":"30","author":"Ben-Nun J","year":"1989","unstructured":"Ben-Nun J, Joyce DA, Cooper RL, Cringle SJ, Constable IJ. Pharmacokinetics of intravitreal injection: assessment of a gentamicin model by ocular dialysis. Invest Ophthalmol Vis Sci. 1989;30(6):1055-1061."},{"issue":"suppl 1","key":"ref19","series-title":"Vet Ophthalmol","first-page":"34","article-title":"Histopathologic evaluation of the anterior segment of eyes enucleated due to glaucoma secondary to primary lens displacement in 13 canine globes","volume":"16","author":"Alario AF","year":"2013","unstructured":"Alario AF, Pizzirani S, Pirie CG. Histopathologic evaluation of the anterior segment of eyes enucleated due to glaucoma secondary to primary lens displacement in 13 canine globes. Vet Ophthalmol. 2013;16(suppl 1):34-41. doi:10.1111\/j.1463-5224.2012.01019.x"},{"issue":"3","key":"ref20","series-title":"Vet Clin North Am Small Anim Pract","first-page":"775","article-title":"Glaucoma in the dog and cat","volume":"20","author":"Brooks DE","year":"1990","unstructured":"Brooks DE. Glaucoma in the dog and cat. Vet Clin North Am Small Anim Pract. 1990;20(3):775-797. doi:10.1016\/S0195-5616(90)50062-5"},{"issue":"8","key":"ref21","series-title":"J Am Vet Med Assoc","first-page":"1270","article-title":"Evaluation of risk factors for development of secondary glaucoma in dogs: 156 cases (1999-2004)","volume":"229","author":"Johnsen DA","year":"2006","unstructured":"Johnsen DA, Maggs DJ, Kass PH. Evaluation of risk factors for development of secondary glaucoma in dogs: 156 cases (1999-2004). J Am Vet Med Assoc. 2006;229(8):1270-1274. doi:10.2460\/javma.229.8.1270"},{"issue":"1","key":"ref22","series-title":"Vet Pathol","first-page":"41","article-title":"The pathogenesis and significance of pre-iridal fibrovascular membrane in domestic animals","volume":"27","author":"Peiffer RL Jr","year":"1990","unstructured":"Peiffer RL Jr, Wilcock BP, Yin H. The pathogenesis and significance of pre-iridal fibrovascular membrane in domestic animals. Vet Pathol. 1990;27(1):41-45. doi:10.1177\/030098589002700106"},{"key":"ref23","series-title":"Vet Comp Ophthalmol","first-page":"267","article-title":"Fluorescein concentrations in the aqueous of dogs with cataracts","volume":"7","author":"Dziezyc J","year":"1997","unstructured":"Dziezyc J, Millichamp NJ, Smith WB. Fluorescein concentrations in the aqueous of dogs with cataracts. Vet Comp Ophthalmol. 1997;7:267-270."},{"issue":"suppl 1","key":"ref24","series-title":"Vet Ophthalmol","first-page":"21","article-title":"Aqueous humor vascular endothelial growth factor in dogs: association with intraocular disease and the development of pre-iridal fibrovascular membrane","volume":"15","author":"Sandberg CA","year":"2012","unstructured":"Sandberg CA, Herring IP, Huckle WR, LeRoith T, Pickett JP, Rossmeisl JH. Aqueous humor vascular endothelial growth factor in dogs: association with intraocular disease and the development of pre-iridal fibrovascular membrane. Vet Ophthalmol. 2012;15(suppl 1):21-30. doi:10.1111\/j.1463-5224.2011.00931.x"},{"issue":"2","key":"ref25","series-title":"Curr Eye Res","first-page":"81","article-title":"The relationship between age and intraocular pressure in a Japanese population: the influence of central corneal thickness","volume":"24","author":"Nomura H","year":"2002","unstructured":"Nomura H, Ando F, Niino N, Shimokata H, Miyake Y. The relationship between age and intraocular pressure in a Japanese population: the influence of central corneal thickness. Curr Eye Res. 2002;24(2):81-85. doi:10.1076\/ceyr.24.2.81.8161"},{"issue":"2-3","key":"ref26","series-title":"Vet Ophthalmol","first-page":"109","article-title":"Distribution of intraocular pressure in dogs","volume":"1","author":"Gelatt KN","year":"1998","unstructured":"Gelatt KN, MacKay EO. Distribution of intraocular pressure in dogs. Vet Ophthalmol. 1998;1(2-3):109-114. doi:10.1046\/j.1463-5224.1998.00024.x"},{"issue":"6","key":"ref27","series-title":"Am J Ophthalmol","first-page":"1079","article-title":"Aging changes of the ciliary epithelium border layers and their significance for intraocular pressure","volume":"72","author":"G\u00e4rtner J","year":"1971","unstructured":"G\u00e4rtner J. Aging changes of the ciliary epithelium border layers and their significance for intraocular pressure. Am J Ophthalmol. 1971;72(6):1079-1093. doi:10.1016\/0002-9394(71)91213-X"},{"issue":"4","key":"ref28","series-title":"Am J Ophthalmol","first-page":"407","article-title":"Aqueous humor dynamics in the aging human eye","volume":"127","author":"Toris CB","year":"1999","unstructured":"Toris CB, Yablonski ME, Wang YL, Camras CB. Aqueous humor dynamics in the aging human eye. Am J Ophthalmol. 1999;127(4):407-412. doi:10.1016\/S0002-9394(98)00436-X"},{"issue":"3","key":"ref29","series-title":"Ophthalmology","first-page":"283","article-title":"The effect of age on aqueous humor formation in man","volume":"88","author":"Brubaker RF","year":"1981","unstructured":"Brubaker RF, Nagataki S, Townsend DJ, Burns RR, Higgins RG, Wentworth W. The effect of age on aqueous humor formation in man. Ophthalmology. 1981;88(3):283-288. doi:10.1016\/S0161-6420(81)35037-4"},{"issue":"6","key":"ref30","series-title":"Exp Eye Res","first-page":"651","article-title":"Studies of aqueous humour dynamics in man, VI: effect of age upon parameters of intraocular pressure in normal human eyes","volume":"26","author":"Gaasterland D","year":"1978","unstructured":"Gaasterland D, Kupfer C, Milton R, Ross K, McCain L, MacLellan H. Studies of aqueous humour dynamics in man, VI: effect of age upon parameters of intraocular pressure in normal human eyes. Exp Eye Res. 1978;26(6):651-656. doi:10.1016\/0014-4835(78)90099-4"},{"key":"ref31","series-title":"Veterinary Ophthalmology","first-page":"151","article-title":"Physiology of the eye","author":"Hendrix DV","year":"2021","unstructured":"Hendrix DV, Thomasy SM, Gum GG. Physiology of the eye. In: Gelatt KN, ed. Veterinary Ophthalmology. 6th ed. Wiley Blackwell; 2021:151-153."},{"issue":"2","key":"ref32","series-title":"Vet Ophthalmol","first-page":"159","article-title":"Canine ocular tumors following ciliary body ablation with intravitreal gentamicin","volume":"16","author":"Duke FD","year":"2013","unstructured":"Duke FD, Strong TD, Bentley E, Dubielzig RR. Canine ocular tumors following ciliary body ablation with intravitreal gentamicin. Vet Ophthalmol. 2013;16(2):159-162. doi:10.1111\/j.1463-5224.2012.01050.x"},{"issue":"3","key":"ref33","series-title":"Vet Ophthalmol","first-page":"169","article-title":"Effect of central corneal thickness on intraocular pressure with the rebound tonometer and the applanation tonometer in normal dogs","volume":"14","author":"Park YW","year":"2011","unstructured":"Park YW, Jeong MB, Kim TH,  Effect of central corneal thickness on intraocular pressure with the rebound tonometer and the applanation tonometer in normal dogs. Vet Ophthalmol. 2011;14(3):169-173. doi:10.1111\/j.1463-5224.2010.00859.x"},{"issue":"1","key":"ref34","series-title":"BMC Ophthalmol","first-page":"3","article-title":"Inaccuracy of intraocular pressure measurement in congenital corneal opacity: three case reports","volume":"20","author":"Kang BS","year":"2020","unstructured":"Kang BS, Jeoung JW, Oh JY. Inaccuracy of intraocular pressure measurement in congenital corneal opacity: three case reports. BMC Ophthalmol. 2020;20(1):3. doi:10.1186\/s12886-019-1287-7"},{"key":"ref35","article-title":"Effectiveness of gentamicin for pharmacologic ablation to treat end-stage glaucoma in dogs","author":"Marchione B","unstructured":"Marchione B. daSilvaCuriel J, Zhou Y, , editors. Effectiveness of gentamicin for pharmacologic ablation to treat end-stage glaucoma in dogs. Abstract presented at: Annual Conference of the American College of Veterinary Ophthalmologists; October 26-29, 2011; Hilton Head, SC."}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/262\/S2\/javma.24.03.0199.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/262\/S2\/javma.24.03.0199.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/262\/S2\/javma.24.03.0199.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T13:51:07Z","timestamp":1732283467000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/262\/S2\/javma.24.03.0199.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,1]]},"references-count":35,"journal-issue":{"issue":"S2"},"URL":"https:\/\/doi.org\/10.2460\/javma.24.03.0199","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12,1]]}}}