{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:26:56Z","timestamp":1788820016868,"version":"build-2803163510"},"reference-count":50,"publisher":"American Veterinary Medical Association (AVMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To determine the effect of tranexamic acid (TXA) on clot hyperfibrinolysis (HF), defined as excessive clot lysis at 30 minutes (LY30%), with rapid thromboelastography (rTEG) or rTEG samples spiked with tissue plasminogen activator (tPA-stressed rTEG), in dogs with hemorrhagic shock.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>Prospective blinded clinical trial at 2 teaching hospitals, March 16, 2018, to May 20, 2022. Twenty-five dogs with hemorrhagic shock and HF were treated with standard care plus either TXA (20 mg\/kg; TXA group) or saline (SAL group) over 20 minutes followed by an infusion of the same dose over 8 hours. Rapid TEG and tPA-stressed rTEG assays were performed immediately before study drug administration and at 8, 12, and 24 hours afterwards (T0, T8, T12, and T24, respectively).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>4 dogs died or were euthanized before the end of the study period due to disease\/injury severity. All survivors had normal rTEG LY30% values after T0; the value for 1 nonsurvivor increased at T8. The tPA-stressed LY30% normalized in all TXA (n = 14) and 8 of 11 SAL dogs at T8; TXA dogs had lower median tPA-stressed rTEG LY30% values at T8 and T12 than SAL dogs (<jats:italic>P<\/jats:italic> = .001 and .02, respectively). There was no treatment effect on blood product administration or survival, and no adverse effects were attributed to TXA administration.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>Resuscitation with or without TXA reduced HF identified by tPA-stressed rTEG. Hyperfibrinolysis was completely suppressed at the conclusion of the 8-hour TXA infusion.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Although TXA treatment stopped HF, there was no effect on survival or transfusion requirements.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.24.03.0216","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T15:02:13Z","timestamp":1726844533000},"page":"54-62","source":"Crossref","is-referenced-by-count":5,"title":["Tranexamic acid stops hyperfibrinolysis in dogs with hemorrhagic shock: a randomized, controlled clinical trial"],"prefix":"10.2460","volume":"263","author":[{"given":"Erin Long","family":"Mays","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, North Carolina State University, Raleigh, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernie","family":"Hansen","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, North Carolina State University, Raleigh, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Culbreth","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, North Carolina State University, Raleigh, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Hanel","sequence":"additional","affiliation":[{"name":"Veterinary Emergency Group, White Plains, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Majoy","sequence":"additional","affiliation":[{"name":"Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Rozanski","sequence":"additional","affiliation":[{"name":"Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armelle","family":"DeLaforcade","sequence":"additional","affiliation":[{"name":"Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"6","key":"ref1","series-title":"Curr Opin Crit Care","first-page":"680","article-title":"Acute coagulopathy of trauma: mechanism, identification and effect","volume":"13","author":"Brohi K","year":"2007","unstructured":"Brohi K, Cohen MJ, Davenport RA. 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