{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:14:43Z","timestamp":1789168483733,"version":"build-2803163510"},"reference-count":33,"publisher":"American Veterinary Medical Association (AVMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2025,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To evaluate whether abdominal ultrasound correctly diagnosed septic peritonitis and correctly identified its causative lesion in dogs and cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>ANIMALS<\/jats:title>\n                    <jats:p>84 client-owned dogs and 10 cats that underwent an abdominal ultrasound and had confirmation of septic peritonitis via exploratory laparotomy or necropsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This retrospective case series documented abdominal ultrasound findings, surgical or necropsy findings, and method for initial diagnosis of septic peritonitis, if different from surgery or necropsy. The surgical report and necropsy findings were compared to sonography results to confirm a diagnosis of septic peritonitis. The frequency at which sonography diagnosed septic peritonitis and its causative lesion was calculated for each type of lesion pathology and organ system. Secondary aims included evaluating the effect of patient characteristics (body weight and species) on sonographic results and whether lesion type or location affected mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Most lesions causing septic peritonitis (70.2%) were gastrointestinal in origin and were nonneoplastic ulcerations or perforations (50%). Abdominal ultrasound diagnosed 56.3% of cases of subsequently confirmed septic peritonitis and correctly identified 67% of the causative lesions. Lesions of the gastrointestinal tract and ulcerations\/perforations were the most frequent correct sonographic diagnoses and most likely to lead to a correct sonographic diagnosis of septic peritonitis. Lesions located in the hepatobiliary system and lesion types other than neoplasia or ulcerations\/perforations were the most frequently missed by abdominal ultrasound.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CLINICAL RELEVANCE<\/jats:title>\n                    <jats:p>Abdominal ultrasound often fails to diagnose septic peritonitis or the underlying causative lesion, and its accuracy depends on the affected organ and type of lesion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/javma.24.04.0271","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T12:56:02Z","timestamp":1724849762000},"page":"343-350","source":"Crossref","is-referenced-by-count":4,"title":["Abdominal ultrasound has inconsistent agreement with subsequent surgery or necropsy findings in dogs and cats with septic peritonitis"],"prefix":"10.2460","volume":"263","author":[{"given":"Curtis G.","family":"Rheingold","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cody","family":"Dickens","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4719-8507","authenticated-orcid":true,"given":"Anna","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecka S.","family":"Hess","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yekaterina","family":"Buriko","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"9","key":"ref1","series-title":"J Small Anim Pract","first-page":"744","article-title":"Outcome following surgery to treat septic peritonitis in 95 cats in the United Kingdom","volume":"62","author":"Anderson T","year":"2021","unstructured":"Anderson T, Beever L, Hall J,  Outcome following surgery to treat septic peritonitis in 95 cats in the United Kingdom. J Small Anim Pract. 2021;62(9):744-749. doi:10.1111\/jsap.13346"},{"key":"ref2","series-title":"Small Animal Surgical Emergencies","first-page":"119","article-title":"Peritonitis","author":"Bentley A","year":"2022","unstructured":"Bentley A, Balakrishnan A. Peritonitis. In: LR Aronson, ed. Small Animal Surgical Emergencies. 2nd ed. Wiley Blackwell; 2022:119-140."},{"issue":"6","key":"ref3","series-title":"Vet Rec","first-page":"e2134","article-title":"Aetiology, clinical parameters and outcome in 113 dogs surgically treated for septic peritonitis (2004-2020)","volume":"192","author":"Shipov A","year":"2023","unstructured":"Shipov A, Lenchner I, Milgram J,  Aetiology, clinical parameters and outcome in 113 dogs surgically treated for septic peritonitis (2004-2020). Vet Rec. 2023;192(6):e2134. doi:10.1002\/vetr.2134"},{"key":"ref4","series-title":"J Am Vet Med Assoc","article-title":"Acute kidney injury is common in dogs with septic peritonitis and is associated with increased mortality","author":"Snipes MM","unstructured":"Snipes MM, Schmiedt CW, Louren\u00e7o BN,  Acute kidney injury is common in dogs with septic peritonitis and is associated with increased mortality. J Am Vet Med Assoc. Published online August 15, 2023. doi:10.2460\/javma.23.04.0184"},{"issue":"1","key":"ref5","series-title":"J Am Vet Med Assoc","first-page":"83","article-title":"Association between outcome and organ system dysfunction in dogs with sepsis: 114 cases (2003-2007)","volume":"236","author":"Kenney EM","year":"2010","unstructured":"Kenney EM, Rozanski EA, Rush JE,  Association between outcome and organ system dysfunction in dogs with sepsis: 114 cases (2003-2007). J Am Vet Med Assoc. 2010;236(1):83-87. doi:10.2460\/javma.236.1.83"},{"issue":"6","key":"ref6","series-title":"J Am Anim Hosp Assoc","first-page":"268","article-title":"Primary bacterial septic peritonitis in cats: 13 cases","volume":"45","author":"Ruthrauff CM","year":"2009","unstructured":"Ruthrauff CM, Smith J, Glerum L. Primary bacterial septic peritonitis in cats: 13 cases. J Am Anim Hosp Assoc. 2009;45(6):268-276. doi:10.5326\/0450268"},{"issue":"10","key":"ref7","series-title":"J Small Anim Pract","first-page":"518","article-title":"A retrospective study of surgically treated cases of septic peritonitis in the cat (2000-2007)","volume":"50","author":"Parsons KJ","year":"2009","unstructured":"Parsons KJ, Owen LJ, Lee K, Tivers MS, Gregory SP. A retrospective study of surgically treated cases of septic peritonitis in the cat (2000-2007). J Small Anim Pract. 2009;50(10):518-524. doi:10.1111\/j.1748-5827.2009.00790.x"},{"issue":"6","key":"ref8","series-title":"J Am Vet Med Assoc","first-page":"897","article-title":"Underlying cause, pathophysiologic abnormalities, and response to treatment in cats with septic peritonitis: 51 cases (1990-2001)","volume":"225","author":"Costello MF","year":"2004","unstructured":"Costello MF, Drobatz KJ, Aronson LR, King LG. Underlying cause, pathophysiologic abnormalities, and response to treatment in cats with septic peritonitis: 51 cases (1990-2001). J Am Vet Med Assoc. 2004;225(6):897-902. doi:10.2460\/javma.2004.225.897"},{"issue":"6","key":"ref9","series-title":"J Am Vet Med Assoc","first-page":"789","article-title":"Use of closed-suction drains to treat generalized peritonitis in dogs and cats: 40 cases (1997-1999)","volume":"219","author":"Mueller MG","year":"2001","unstructured":"Mueller MG, Ludwig LL, Barton LJ. Use of closed-suction drains to treat generalized peritonitis in dogs and cats: 40 cases (1997-1999). J Am Vet Med Assoc. 2001;219(6):789-794. doi:10.2460\/javma.2001.219.789"},{"issue":"2","key":"ref10","series-title":"J Vet Emerg Crit Care (San Antonio)","first-page":"281","article-title":"Retrospective evaluation of recurrent secondary septic peritonitis in dogs (2000-2011): 41 cases","volume":"26","author":"Barfield DM","year":"2016","unstructured":"Barfield DM, Tivers MS, Holahan M, Welch K, House A, Adamantos SE. Retrospective evaluation of recurrent secondary septic peritonitis in dogs (2000-2011): 41 cases. J Vet Emerg Crit Care (San Antonio). 2016;26(2):281-287. doi:10.1111\/vec.12413"},{"issue":"6","key":"ref11","series-title":"J Vet Emerg Crit Care (San Antonio)","first-page":"635","article-title":"Effect of peritoneal lavage on bacterial isolates in 40 dogs with confirmed septic peritonitis","volume":"29","author":"Marshall H","year":"2019","unstructured":"Marshall H, Sinnott-Stutzman V, Ewing P, Bracker K, Kalis R, Khorzad R. Effect of peritoneal lavage on bacterial isolates in 40 dogs with confirmed septic peritonitis. J Vet Emerg Crit Care (San Antonio). 2019;29(6):635-642. doi:10.1111\/vec.12893"},{"issue":"6","key":"ref12","series-title":"J Feline Med Surg","first-page":"559","article-title":"Multiorgan dysfunction syndrome in feline sepsis: prevalence and prognostic implication","volume":"21","author":"Tro\u00eca R","year":"2019","unstructured":"Tro\u00eca R, Mascalzoni G, Calipa S, Magagnoli I, Dondi F, Giunti M. Multiorgan dysfunction syndrome in feline sepsis: prevalence and prognostic implication. J Feline Med Surg. 2019;21(6):559-565. doi:10.1177\/1098612X18792106"},{"issue":"4","key":"ref13","series-title":"J Am Anim Hosp Assoc","first-page":"254","article-title":"Evaluation of data from 35 dogs pertaining to dehiscence following intestinal resection and anastomosis","volume":"50","author":"Mouat EE","year":"2014","unstructured":"Mouat EE, Davis GJ, Drobatz KJ, Wallace KA. Evaluation of data from 35 dogs pertaining to dehiscence following intestinal resection and anastomosis. J Am Anim Hosp Assoc. 2014;50(4):254-263. doi:10.5326\/JAAHA-MS-6111"},{"issue":"3","key":"ref14","series-title":"J Vet Emerg Crit Care (San Antonio)","first-page":"388","article-title":"Plasma lactate concentrations in septic peritonitis: a retrospective study of 83 dogs (2007-2012)","volume":"25","author":"Cortellini S","year":"2015","unstructured":"Cortellini S, Seth M, Kellett-Gregory LM. Plasma lactate concentrations in septic peritonitis: a retrospective study of 83 dogs (2007-2012). J Vet Emerg Crit Care (San Antonio). 2015;25(3):388-395. doi:10.1111\/vec.12234"},{"issue":"1","key":"ref15","series-title":"J Vet Emerg Crit Care (San Antonio)","first-page":"152","article-title":"Impact of appropriate empirical antimicrobial therapy on outcome of dogs with septic peritonitis","volume":"25","author":"Dickinson AE","year":"2015","unstructured":"Dickinson AE, Summers JF, Wignal J, Boag AK, Keir I. Impact of appropriate empirical antimicrobial therapy on outcome of dogs with septic peritonitis. J Vet Emerg Crit Care (San Antonio). 2015;25(1):152-159. doi:10.1111\/vec.12273"},{"issue":"6","key":"ref16","series-title":"J Vet Emerg Crit Care (San Antonio)","first-page":"647","article-title":"Prognostic indicators in cats with septic peritonitis (2002-2015): 83 cases","volume":"29","author":"Scotti KM","year":"2019","unstructured":"Scotti KM, Koenigshof A, Sri-Jayantha LSH,  Prognostic indicators in cats with septic peritonitis (2002-2015): 83 cases. J Vet Emerg Crit Care (San Antonio). 2019;29(6):647-652. doi:10.1111\/vec.12896"},{"issue":"2","key":"ref17","series-title":"J Am Anim Hosp Assoc","first-page":"176","article-title":"Spontaneous gastroduodenal perforation in 16 dogs and seven cats (1982-1999)","volume":"38","author":"Hinton LE","year":"2002","unstructured":"Hinton LE, McLoughlin MA, Johnson SE, Weisbrode SE. Spontaneous gastroduodenal perforation in 16 dogs and seven cats (1982-1999). J Am Anim Hosp Assoc. 2002;38(2):176-187. doi:10.5326\/0380176"},{"issue":"5","key":"ref18","series-title":"J Am Anim Hosp Assoc","first-page":"264","article-title":"Comparison of the results of abdominal ultrasonography and exploratory laparotomy in the dog and cat","volume":"43","author":"Pastore GE","year":"2007","unstructured":"Pastore GE, Lamb CR, Lipscomb V. Comparison of the results of abdominal ultrasonography and exploratory laparotomy in the dog and cat. J Am Anim Hosp Assoc. 2007;43(5):264-269. doi:10.5326\/0430264"},{"issue":"5","key":"ref19","series-title":"Vet Radiol Ultrasound","first-page":"556","article-title":"Ultrasonographic findings in dogs and cats with gastrointestinal perforation","volume":"44","author":"Boysen SR","year":"2003","unstructured":"Boysen SR, Tidwell AS, Penninck DG. Ultrasonographic findings in dogs and cats with gastrointestinal perforation. Vet Radiol Ultrasound. 2003;44(5):556-564. doi:10.1111\/j.1740-8261.2003.tb00507.x"},{"issue":"3","key":"ref20","series-title":"Vet Sci","first-page":"39","article-title":"Correlation between preoperative ultrasonographic findings and clinical, intraoperative, cytopathological, and histopathological diagnosis of acute abdomen syndrome in 50 dogs and cats","volume":"4","author":"Abdellatif A","year":"2017","unstructured":"Abdellatif A, Kramer M, Failing K, von P\u00fcckler K. Correlation between preoperative ultrasonographic findings and clinical, intraoperative, cytopathological, and histopathological diagnosis of acute abdomen syndrome in 50 dogs and cats. Vet Sci. 2017;4(3):39. doi:10.3390\/vetsci4030039"},{"key":"ref21","series-title":"Textbook of Veterinary Diagnostic Radiology","first-page":"764","article-title":"Peritoneal space","author":"Stieger-Vanegas SM","year":"2018","unstructured":"Stieger-Vanegas SM, Frank PM. Peritoneal space. In: Thrall DE, ed. Textbook of Veterinary Diagnostic Radiology. 7th ed. Elsevier; 2018:764-791. doi:10.1016\/B978-0-323-48247-9.00051-6"},{"issue":"6","key":"ref22","series-title":"J Am Anim Hosp Assoc","first-page":"549","article-title":"Idiopathic pneumoperitoneum in a dog","volume":"37","author":"Mehl ML","year":"2001","unstructured":"Mehl ML, Seguin B, Norrdin RW, Geddes S, Withrow SJ. Idiopathic pneumoperitoneum in a dog. J Am Anim Hosp Assoc. 2001;37(6):549-551. doi:10.5326\/15473317-37-6-549"},{"issue":"4","key":"ref23","series-title":"J Am Vet Med Assoc","first-page":"462","article-title":"Pneumoperitoneum in dogs and cats: 39 cases (1983-2002)","volume":"223","author":"Saunders WB","year":"2003","unstructured":"Saunders WB, Tobias KM. Pneumoperitoneum in dogs and cats: 39 cases (1983-2002). J Am Vet Med Assoc. 2003;223(4):462-468. doi:10.2460\/javma.2003.223.462"},{"issue":"2","key":"ref24","series-title":"Can Vet J","first-page":"138","article-title":"Large-volume pneumoperitoneum and septic peritonitis secondary to splenic abscess rupture in a dog","volume":"61","author":"Rubanick JV","year":"2020","unstructured":"Rubanick JV, Breiteneicher AH, Thieman-Mankin K. Large-volume pneumoperitoneum and septic peritonitis secondary to splenic abscess rupture in a dog. Can Vet J. 2020;61(2):138-141."},{"issue":"2","key":"ref25","series-title":"Hong Kong J Emerg Med","first-page":"111","article-title":"The value of ultrasound in diagnosis of pneumoperitoneum in emergent or critical conditions: a meta-analysis","volume":"26","author":"Jiang L","year":"2019","unstructured":"Jiang L, Wu J, Feng X. The value of ultrasound in diagnosis of pneumoperitoneum in emergent or critical conditions: a meta-analysis. Hong Kong J Emerg Med. 2019;26(2):111-117. doi:10.1177\/1024907918805668"},{"issue":"4","key":"ref26","series-title":"J Vet Med Sci","first-page":"491","article-title":"Sonographic detection of small amounts of free peritoneal gas in Beagle dogs","volume":"74","author":"Choi H","year":"2012","unstructured":"Choi H, Lee Y, Park K, Yeon S, Lee H. Sonographic detection of small amounts of free peritoneal gas in Beagle dogs. J Vet Med Sci. 2012;74(4):491-494. doi:10.1292\/jvms.11-0375"},{"issue":"2","key":"ref27","series-title":"J Vet Sci","first-page":"195","article-title":"Accuracy of sonographic diagnosis of pneumoperitoneum using the enhanced peritoneal stripe sign in Beagle dogs","volume":"15","author":"Kim SY","year":"2014","unstructured":"Kim SY, Park KT, Yeon SC, Lee HC. Accuracy of sonographic diagnosis of pneumoperitoneum using the enhanced peritoneal stripe sign in Beagle dogs. J Vet Sci. 2014;15(2):195-198. doi:10.4142\/jvs.2014.15.2.195"},{"issue":"2","key":"ref28","series-title":"Vet Surg","first-page":"208","article-title":"Diagnostic accuracy of ultrasound to predict the location of solitary hepatic masses in dogs","volume":"45","author":"Wormser C","year":"2016","unstructured":"Wormser C, Reetz JA, Giuffrida MA. Diagnostic accuracy of ultrasound to predict the location of solitary hepatic masses in dogs. Vet Surg. 2016;45(2):208-213. doi:10.1111\/vsu.12436"},{"issue":"2","key":"ref29","series-title":"Best Pract Res Clin Endocrinol Metab","first-page":"261","article-title":"Diagnostic imaging in obesity","volume":"27","author":"Machann J","year":"2013","unstructured":"Machann J, Horstmann A, Born M, Hesse S, Hirsch FW. Diagnostic imaging in obesity. Best Pract Res Clin Endocrinol Metab. 2013;27(2):261-277. doi:10.1016\/j.beem.2013.02.003"},{"issue":"3","key":"ref30","series-title":"Crit Care","first-page":"R87","article-title":"Time from admission to initiation of surgery for source control is a critical determinant of survival in patients with gastrointestinal perforation with associated septic shock","volume":"18","author":"Azuhata T","year":"2014","unstructured":"Azuhata T, Kinoshita K, Kawano D,  Time from admission to initiation of surgery for source control is a critical determinant of survival in patients with gastrointestinal perforation with associated septic shock. Crit Care. 2014;18(3):R87. doi:10.1186\/cc13854"},{"issue":"8","key":"ref31","series-title":"Br J Surg","first-page":"1045","article-title":"Danish Clinical Register of Emergency Surgery. Surgical delay is a critical determinant of survival in perforated peptic ulcer","volume":"100","author":"Buck DL","year":"2013","unstructured":"Buck DL, Vester-Andersen M, M\u00f8ller MH; Danish Clinical Register of Emergency Surgery. Surgical delay is a critical determinant of survival in perforated peptic ulcer. Br J Surg. 2013;100(8):1045-1049. doi:10.1002\/bjs.9175"},{"issue":"9","key":"ref32","series-title":"JAMA Surg","first-page":"817","article-title":"Association between time to source control in sepsis and 90-day mortality","volume":"157","author":"Reitz KM","year":"2022","unstructured":"Reitz KM, Kennedy J, Li SR,  Association between time to source control in sepsis and 90-day mortality. JAMA Surg. 2022;157(9):817-826. doi:10.1001\/jamasurg.2022.2761"},{"issue":"10","key":"ref33","series-title":"World J Gastrointest Surg","first-page":"2320","article-title":"Timing of surgical operation for patients with intra-abdominal infection: a systematic review and meta-analysis","volume":"15","author":"Song SR","year":"2023","unstructured":"Song SR, Liu YY, Guan YT,  Timing of surgical operation for patients with intra-abdominal infection: a systematic review and meta-analysis. World J Gastrointest Surg. 2023;15(10):2320-2330. doi:10.4240\/wjgs.v15.i10.2320"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/263\/3\/javma.24.04.0271.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/263\/3\/javma.24.04.0271.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/263\/3\/javma.24.04.0271.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T11:21:32Z","timestamp":1741346492000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/263\/3\/javma.24.04.0271.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,1]]},"references-count":33,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.2460\/javma.24.04.0271","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3,1]]}}}