{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:34:06Z","timestamp":1793331246304,"version":"4.5.0"},"reference-count":31,"publisher":"American Veterinary Medical Association (AVMA)","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To evaluate temporal changes in serum C-reactive protein (CRP) and haptoglobin (Hp) concentrations in dogs with pulmonary coccidioidomycosis and assess their utility to detect remission.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>31 client-owned dogs with newly diagnosed pulmonary coccidioidomycosis from October 2020 to February 2021 were included in a retrospective cohort study that utilized archived serum. Serum was originally obtained at diagnosis and once every 3 months after antifungal administration until either remission or 12 months. Time points were designated as baseline (T0), 3 months (T1), 6 months (T2), 9 months (T3), and 12 months (T4). Serum CRP and Hp were measured at a reference laboratory with ELISA assays.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Median serum CRP and Hp concentrations decreased from T0 (CRP, 56 mg\/L; Hp, 716.1 mg\/dL) to T1 (CRP, 3.3 mg\/L; Hp, 240.5 mg\/dL); subsequent decreases were not significant. Eighteen (60%) and 16 (53%) of 30 dogs had normal serum CRP and Hp concentrations at T1, respectively. Absolute serum CRP (AUC, 0.58; 95% CI, 0.45 to 0.72) and Hp (AUC, 0.65; 95% CI, 0.52 to 0.78) were poor detectors of remission. However, the percentage change in Hp from T0 to T1 (AUC, 0.90; 95% CI, 0.74 to 1.0) was an excellent predictor of remission within 12 months.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>Serum CRP and Hp concentrations decrease in the first 3 months of antifungal treatment in dogs with pulmonary coccidioidomycosis, and the percentage change of Hp may help predict dogs that will achieve remission within 12 months of treatment.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Serum CRP and Hp may be useful adjunctive biomarkers to monitor treatment response in dogs with pulmonary coccidioidomycosis.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.24.05.0296","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T15:23:29Z","timestamp":1718897009000},"page":"1222-1230","source":"Crossref","is-referenced-by-count":4,"title":["Serum C-reactive protein and haptoglobin decrease in the first three months of treatment and relative change in haptoglobin predict remission in dogs with pulmonary coccidioidomycosis"],"prefix":"10.2460","volume":"262","author":[{"given":"Aaren","family":"Glick","sequence":"first","affiliation":[{"name":"Department of Specialty Medicine, College of Veterinary Medicine, Midwestern University, Glendale, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared A.","family":"Jaffey","sequence":"additional","affiliation":[{"name":"Department of Pathology and Population Medicine, College of Veterinary Medicine, Midwestern University, Glendale, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5562-5521","authenticated-orcid":true,"given":"Rachael","family":"Kreisler","sequence":"additional","affiliation":[{"name":"Department of Pathology and Population Medicine, College of Veterinary Medicine, Midwestern University, Glendale, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Hanzlicek","sequence":"additional","affiliation":[{"name":"MiraVista Diagnostics, Indianapolis, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy","family":"Ringold","sequence":"additional","affiliation":[{"name":"VDI Laboratory LLC, Chatsworth, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"suppl 1","key":"ref1","series-title":"Med Mycol.","first-page":"S67","article-title":"Selected clinical features of coccidioidomycosis in dogs","volume":"57","author":"Davidson AP","year":"2019","unstructured":"Davidson AP, Shubitz LF, Alcott CJ, Sykes JE. 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